CAJ | 학술논문

目的探讨胆囊良恶性病变组织中环氧合酶-2(COX-2)与血管内皮生长因子-C(VEGF-C)的表达及其临床病理意义.方法采用免疫组织化学法检测44例胆囊腺癌、10例胆囊腺瘤组织中COX-2与VEGF-C的表达.结果胆囊腺癌和胆囊腺瘤组织中COX-2表达阳性率分别为72.7％和40.0％,胆囊腺癌COX-2的表达率明显高于胆囊腺瘤(P＜0.05).VEGF-C在胆囊腺癌组织中的表达明显高于胆囊腺瘤(63.6％比20.0％,P＜0.05).COX-2与VEGF-C的表达与胆囊腺癌的Nevin分期和淋巴结转移相关.COX-2与VEGF-C表达显著相关.结论 COX-2与VEGF-C表达与胆囊腺癌的发生和生物学行为密切相关.
목적 탐토담낭량악성병변조직중배양합매-2(COX-2)여혈관내피생장인자-C(VEGF-C)적표체급기림상병리의의.방법 채용면역조직화학법검측44례담낭선암、10례담낭선류조직중COX-2여VEGF-C적표체.결과 담낭선암화담낭선류조직중COX-2표체양성솔분별위72.7％화40.0％,담낭선암COX-2적표체솔명현고우담낭선류(P＜0.05).VEGF-C재담낭선암조직중적표체명현고우담낭선류(63.6％비20.0％,P＜0.05).COX-2여VEGF-C적표체여담낭선암적Nevin분기화림파결전이상관.COX-2여VEGF-C표체현저상관.결론 COX-2여VEGF-C표체여담낭선암적발생화생물학행위밀절상관.
Objective To study the expression levels of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor C (VEGF-C) and their clinicopathological significance in benign and malignant lesions of gallbladder.Methods The expression levels of COX-2 and VEGF-C were detected by using immunohistochemistry in 44 cases of gallbladder cancer and 10 cases of gallbladder adenoma.Results The expression rate of COX-2 in gallbladder adenocarcinoma and adenoma was 72.7％％ and 40.0％ respectively.The expression rate of COX-2 in gallbladder adenocarcinoma was higher than that in gallbladder adenoma (P ＜ 0.05).The expression rate of VEGF-C in gallbladder adenocarcinoma was higher than that in gallbladder adenoma (63.6％ vs.20.0％,P ＜ 0.05).There was a significant correlation between the expression of COX-2,VEGF-C and Nevin stages and lymph node metastasis of gallbladder carcinoma.There was a significant relationship between COX-2 and VEGF-C.Conclusion The expression of COX-2 and VEGF-C might be closely related to the carcinogenesis and biological behaviors of gallbladder adenocarcino