中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2012年
11期
2120-2121
,共2页
穆宏凌%吕海涛%王文斌%刘三光%张树彬
穆宏凌%呂海濤%王文斌%劉三光%張樹彬
목굉릉%려해도%왕문빈%류삼광%장수빈
胆囊肿瘤%环氧化酶-2%血管内皮生长因子-C
膽囊腫瘤%環氧化酶-2%血管內皮生長因子-C
담낭종류%배양화매-2%혈관내피생장인자-C
Gallbladder neoplasms%Cyclooxygenase-2%Vascular endoehelial growth factor C
目的 探讨胆囊良恶性病变组织中环氧合酶-2(COX-2)与血管内皮生长因子-C(VEGF-C)的表达及其临床病理意义.方法 采用免疫组织化学法检测44例胆囊腺癌、10例胆囊腺瘤组织中COX-2与VEGF-C的表达.结果 胆囊腺癌和胆囊腺瘤组织中COX-2表达阳性率分别为72.7%和40.0%,胆囊腺癌COX-2的表达率明显高于胆囊腺瘤(P<0.05).VEGF-C在胆囊腺癌组织中的表达明显高于胆囊腺瘤(63.6%比20.0%,P<0.05).COX-2与VEGF-C的表达与胆囊腺癌的Nevin分期和淋巴结转移相关.COX-2与VEGF-C表达显著相关.结论 COX-2与VEGF-C表达与胆囊腺癌的发生和生物学行为密切相关.
目的 探討膽囊良噁性病變組織中環氧閤酶-2(COX-2)與血管內皮生長因子-C(VEGF-C)的錶達及其臨床病理意義.方法 採用免疫組織化學法檢測44例膽囊腺癌、10例膽囊腺瘤組織中COX-2與VEGF-C的錶達.結果 膽囊腺癌和膽囊腺瘤組織中COX-2錶達暘性率分彆為72.7%和40.0%,膽囊腺癌COX-2的錶達率明顯高于膽囊腺瘤(P<0.05).VEGF-C在膽囊腺癌組織中的錶達明顯高于膽囊腺瘤(63.6%比20.0%,P<0.05).COX-2與VEGF-C的錶達與膽囊腺癌的Nevin分期和淋巴結轉移相關.COX-2與VEGF-C錶達顯著相關.結論 COX-2與VEGF-C錶達與膽囊腺癌的髮生和生物學行為密切相關.
목적 탐토담낭량악성병변조직중배양합매-2(COX-2)여혈관내피생장인자-C(VEGF-C)적표체급기림상병리의의.방법 채용면역조직화학법검측44례담낭선암、10례담낭선류조직중COX-2여VEGF-C적표체.결과 담낭선암화담낭선류조직중COX-2표체양성솔분별위72.7%화40.0%,담낭선암COX-2적표체솔명현고우담낭선류(P<0.05).VEGF-C재담낭선암조직중적표체명현고우담낭선류(63.6%비20.0%,P<0.05).COX-2여VEGF-C적표체여담낭선암적Nevin분기화림파결전이상관.COX-2여VEGF-C표체현저상관.결론 COX-2여VEGF-C표체여담낭선암적발생화생물학행위밀절상관.
Objective To study the expression levels of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor C (VEGF-C) and their clinicopathological significance in benign and malignant lesions of gallbladder.Methods The expression levels of COX-2 and VEGF-C were detected by using immunohistochemistry in 44 cases of gallbladder cancer and 10 cases of gallbladder adenoma.Results The expression rate of COX-2 in gallbladder adenocarcinoma and adenoma was 72.7% % and 40.0% respectively.The expression rate of COX-2 in gallbladder adenocarcinoma was higher than that in gallbladder adenoma (P < 0.05).The expression rate of VEGF-C in gallbladder adenocarcinoma was higher than that in gallbladder adenoma (63.6% vs.20.0%,P < 0.05).There was a significant correlation between the expression of COX-2,VEGF-C and Nevin stages and lymph node metastasis of gallbladder carcinoma.There was a significant relationship between COX-2 and VEGF-C.Conclusion The expression of COX-2 and VEGF-C might be closely related to the carcinogenesis and biological behaviors of gallbladder adenocarcino