中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2012年
11期
2137-2139
,共3页
闵维雄%徐亮%王育斌%袁世荧
閔維雄%徐亮%王育斌%袁世熒
민유웅%서량%왕육빈%원세형
失血性休克%复苏%血流动力学%醋酸钠林格氏液
失血性休剋%複囌%血流動力學%醋痠鈉林格氏液
실혈성휴극%복소%혈류동역학%작산납림격씨액
Hemorrhagic shock%Resuscitation%Hemodynamics%Acetate ringer' s solution
目的 比较醋酸钠林格氏液(AR)、乳酸林格氏液(LR)和生理盐水(NS)对失血性休克犬碱剩余(BE)、乳酸(LAC)水平及其血液动力学的影响.方法 将健康成年雄性犬15条随机分为3组:AR组、LR组和NS组,用放血法复制失血性休克模型.分别于放血前、复苏前和复苏后5、30、60 min检测血流动力学参数、动脉血气和血乳酸值.结果 平均动脉压(MAP)恢复至休克前的水平,AR组[(41.10±2.18) ml/kg、(28.15±0.29) min]较LR组[(54.17±2.97) ml/kg、(43.26±0.87) min]、NS组[(59.61±2.88) ml/kg、(48.19±1.23) min]所需输液量更少、时间更短,差异有统计学意义(P＜0.05)；复苏30 min后,MAP AR组[(99.25±12.13) mmHg(1mmHg=0.133 kPa)]较LR组[(84.25±11.87)mm Hg]、NS组[(81.25±13.26) mm Hg]明显升高,且AR组较其他组血液pH值、BE及LAC水平显著改善,差异有统计学意义(P＜0.05).结论 醋酸钠林格液比乳酸林格氏液和生理盐水更适合失血性休克犬的早期紧急液体复苏治疗.
目的 比較醋痠鈉林格氏液(AR)、乳痠林格氏液(LR)和生理鹽水(NS)對失血性休剋犬堿剩餘(BE)、乳痠(LAC)水平及其血液動力學的影響.方法 將健康成年雄性犬15條隨機分為3組:AR組、LR組和NS組,用放血法複製失血性休剋模型.分彆于放血前、複囌前和複囌後5、30、60 min檢測血流動力學參數、動脈血氣和血乳痠值.結果 平均動脈壓(MAP)恢複至休剋前的水平,AR組[(41.10±2.18) ml/kg、(28.15±0.29) min]較LR組[(54.17±2.97) ml/kg、(43.26±0.87) min]、NS組[(59.61±2.88) ml/kg、(48.19±1.23) min]所需輸液量更少、時間更短,差異有統計學意義(P＜0.05)；複囌30 min後,MAP AR組[(99.25±12.13) mmHg(1mmHg=0.133 kPa)]較LR組[(84.25±11.87)mm Hg]、NS組[(81.25±13.26) mm Hg]明顯升高,且AR組較其他組血液pH值、BE及LAC水平顯著改善,差異有統計學意義(P＜0.05).結論 醋痠鈉林格液比乳痠林格氏液和生理鹽水更適閤失血性休剋犬的早期緊急液體複囌治療.
목적 비교작산납림격씨액(AR)、유산림격씨액(LR)화생리염수(NS)대실혈성휴극견감잉여(BE)、유산(LAC)수평급기혈액동역학적영향.방법 장건강성년웅성견15조수궤분위3조:AR조、LR조화NS조,용방혈법복제실혈성휴극모형.분별우방혈전、복소전화복소후5、30、60 min검측혈류동역학삼수、동맥혈기화혈유산치.결과 평균동맥압(MAP)회복지휴극전적수평,AR조[(41.10±2.18) ml/kg、(28.15±0.29) min]교LR조[(54.17±2.97) ml/kg、(43.26±0.87) min]、NS조[(59.61±2.88) ml/kg、(48.19±1.23) min]소수수액량경소、시간경단,차이유통계학의의(P＜0.05)；복소30 min후,MAP AR조[(99.25±12.13) mmHg(1mmHg=0.133 kPa)]교LR조[(84.25±11.87)mm Hg]、NS조[(81.25±13.26) mm Hg]명현승고,차AR조교기타조혈액pH치、BE급LAC수평현저개선,차이유통계학의의(P＜0.05).결론 작산납림격액비유산림격씨액화생리염수경괄합실혈성휴극견적조기긴급액체복소치료.
Objective To investigate the effects of acetate ringer's solution (AR),lactate ringer's solution (LR) and normal saline (NS) on the beecf (BE),lactate (LAC) and hemodynamics in dogs with hemorrhagic shock.Methods Fifteen male healthy adult dogs were divided randomly into 3 groups:AR group,LR group and NS group,each consisting of 5 animals.Hemodynamic parameters,arterial blood gases and LAC were measured before blood-letting,before and 5,30,60,120 min after resuscitation.Results Mean arterial pressure (MAP) recovered to pre-shock level.The volume and time of fluid infusion in AR group [(41.10 ±2.18) ml/kg and 28.15 ±0.29) min] was decreased as compared with LR group [(54.17 ±2.97) ml/kg and (43.26 ±0.87) min] and NS group [(59.61 ±2.88) ml/kg and (48.19 ± 1.23) min] (P ＜0.05).Thirty min after resuscitation,the MAP was increased significantly in AR group [(99.25 ± 12.13) mm Hg (1 mm Hg =0.133 kPa)] as compared with LR group [(84.25 ±11.87) mm Hg)] and NS group [(81.25 ± 13.26) mm Hg] (P＜0.05),and the pH,BE and LAC were improved significantly in AR group as compared with those in IR and NS groups (P ＜ 0.05).Conclusion Acetate ringer' s solution is fitter for the early therapy of hemorrhagic shock than normal saline and lactate ringer's solution.
