中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2012年
12期
2402-2404
,共3页
冯船洋%宋希双%杨德勇%陈峰
馮船洋%宋希雙%楊德勇%陳峰
풍선양%송희쌍%양덕용%진봉
肾癌%转移%趋化因子
腎癌%轉移%趨化因子
신암%전이%추화인자
Renal cell carcinoma%Metastasis%Chemokines
目的 检测转移性肾癌与非转移性肾癌细胞因子受体4(CXCR4)表达强度的差异,以及肾癌常见转移部位淋巴结与肾癌罕见转移部位输尿管基质细胞衍生因子-1(SDF-1)表达强度的差异,探讨SDF-1及其受体生物学轴(SDF-1/CXCR4生物学轴)与肾癌转移的关系.方法 选取转移性肾透明细胞癌标本32例,非转移性肾透明细胞癌标本31例.采用免疫组织化学方法检测转移性肾癌与非转移性肾癌CXCR4表达强度的差异.选取肾透明细胞癌患者淋巴结标本30例;肾透明细胞癌患者输尿管标本30例.采用免疫组织化学的方法检测肾癌常见转移部位淋巴结与肾癌罕见转移部位输尿管SDF-1表达强度的差异.结果 32例转移性肾透明细胞癌CXCR4表达强度评分为(126.72±74.72)分,31例非转移性肾透明细胞癌CXCR4表达强度评分为(63.39±60.69)分.两者差异有统计学意义(P＜0.05).30例淋巴结SDF-1表达强度评分为(145.00±46.42)分,30例输尿管SDF-1表达强度评分为(63.50±23.49)分.两者差异有统计学意义,P＜0.05.结论 转移性肾癌比非转移性肾癌CXCR4表达强度高.CXCR4表达强度高的肾癌更容易发生转移.肾癌常见转移部位淋巴结比肾癌罕见转移部位输尿管SDF-1表达强度高.SDF-1表达强度高的部位更容易发生转移.
目的 檢測轉移性腎癌與非轉移性腎癌細胞因子受體4(CXCR4)錶達彊度的差異,以及腎癌常見轉移部位淋巴結與腎癌罕見轉移部位輸尿管基質細胞衍生因子-1(SDF-1)錶達彊度的差異,探討SDF-1及其受體生物學軸(SDF-1/CXCR4生物學軸)與腎癌轉移的關繫.方法 選取轉移性腎透明細胞癌標本32例,非轉移性腎透明細胞癌標本31例.採用免疫組織化學方法檢測轉移性腎癌與非轉移性腎癌CXCR4錶達彊度的差異.選取腎透明細胞癌患者淋巴結標本30例;腎透明細胞癌患者輸尿管標本30例.採用免疫組織化學的方法檢測腎癌常見轉移部位淋巴結與腎癌罕見轉移部位輸尿管SDF-1錶達彊度的差異.結果 32例轉移性腎透明細胞癌CXCR4錶達彊度評分為(126.72±74.72)分,31例非轉移性腎透明細胞癌CXCR4錶達彊度評分為(63.39±60.69)分.兩者差異有統計學意義(P＜0.05).30例淋巴結SDF-1錶達彊度評分為(145.00±46.42)分,30例輸尿管SDF-1錶達彊度評分為(63.50±23.49)分.兩者差異有統計學意義,P＜0.05.結論 轉移性腎癌比非轉移性腎癌CXCR4錶達彊度高.CXCR4錶達彊度高的腎癌更容易髮生轉移.腎癌常見轉移部位淋巴結比腎癌罕見轉移部位輸尿管SDF-1錶達彊度高.SDF-1錶達彊度高的部位更容易髮生轉移.
목적 검측전이성신암여비전이성신암세포인자수체4(CXCR4)표체강도적차이,이급신암상견전이부위림파결여신암한견전이부위수뇨관기질세포연생인자-1(SDF-1)표체강도적차이,탐토SDF-1급기수체생물학축(SDF-1/CXCR4생물학축)여신암전이적관계.방법 선취전이성신투명세포암표본32례,비전이성신투명세포암표본31례.채용면역조직화학방법검측전이성신암여비전이성신암CXCR4표체강도적차이.선취신투명세포암환자림파결표본30례;신투명세포암환자수뇨관표본30례.채용면역조직화학적방법검측신암상견전이부위림파결여신암한견전이부위수뇨관SDF-1표체강도적차이.결과 32례전이성신투명세포암CXCR4표체강도평분위(126.72±74.72)분,31례비전이성신투명세포암CXCR4표체강도평분위(63.39±60.69)분.량자차이유통계학의의(P＜0.05).30례림파결SDF-1표체강도평분위(145.00±46.42)분,30례수뇨관SDF-1표체강도평분위(63.50±23.49)분.량자차이유통계학의의,P＜0.05.결론 전이성신암비비전이성신암CXCR4표체강도고.CXCR4표체강도고적신암경용역발생전이.신암상견전이부위림파결비신암한견전이부위수뇨관SDF-1표체강도고.SDF-1표체강도고적부위경용역발생전이.
Objective To investigate the relationship between stromal cell derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) biological axis and renal cell carcinoma metastasis,by detecting differential expression of CXCR4 between metastatic renal cell carcinoma and non-metastatic renal cell carcinoma and the difference in SDF-1 expression between the lymphnode and ureter.Methods Metastatic renal clear cell carcinoma specimens were collected from 32 cases,and non-metastatic renal clear cell carcinoma specimens from 31 cases.The difference in CXCR4 expression between metastatic renal cell carcinoma and non-metastatic renal cell carcinoma expression was detected by using immunohistochemistry.The lymph node specimens (n =30) and ureteral specimens (n =30) were selected from patients with renal cell carcinoma.The difference in the SDF-1 expression between the lymph node and ureter was compared.Results In 32 patients with metastatic renal cell carcinoma,the CXCR4 expression score was (126.72 ± 74.72),and that in 31 cases of non-metastatic renal cell carcinoma was (63.39 ± 60.69) (t test,P ＜0.05).In 30 cases of lymph node specimens,the SDF-1 expression score was 145.00 ±46.42,and that in 30 cases of ureteral specimens was 63.50 ± 23.49,P ＜ 0.05.Conclusion CXCR4 expression in metastatic renal cell carcinoma was higher than in non-metastatic renal cell carcinoma.The SDF-1 expression in lymph nodes was higher than in the ureter.
