CAJ | 학술논문

目的探讨晚期糖基化终末产物受体蛋白(RAGE)和细胞增殖核抗原(Ki-67)联合评估对结肠癌预后的预测价值.方法检测160例结肠癌标本中RAGE和Ki-67的表达,并分析两者与临床资料及预后的相关性.结果结肠癌组织高表达RAGE和Ki-67;RAGE的表达与肿瘤直径、分化程度、TNM分期和Ki-67的表达密切相关(P ＜0.05);Cox多因素回归分析显示,TNM分期[风险比(OR) =1.99]、Ki-67(OR=1.68)、RAGE(OR=1.62)、Ki-67和RAGE共表达(OR =2.01)是患者的独立预后因素;RAGE和Ki-67双阴性者生存最佳,双阳性者最短,RAGE或Ki-67的阳性者介乎两者之间.结论 RAGE和Ki-67联合评估可作为结肠癌预后独立预测指标.
목적 탐토만기당기화종말산물수체단백(RAGE)화세포증식핵항원(Ki-67)연합평고대결장암예후적예측개치.방법 검측160례결장암표본중RAGE화Ki-67적표체,병분석량자여림상자료급예후적상관성.결과 결장암조직고표체RAGE화Ki-67;RAGE적표체여종류직경、분화정도、TNM분기화Ki-67적표체밀절상관(P ＜0.05);Cox다인소회귀분석현시,TNM분기[풍험비(OR) =1.99]、Ki-67(OR=1.68)、RAGE(OR=1.62)、Ki-67화RAGE공표체(OR =2.01)시환자적독립예후인소;RAGE화Ki-67쌍음성자생존최가,쌍양성자최단,RAGE혹Ki-67적양성자개호량자지간.결론 RAGE화Ki-67연합평고가작위결장암예후독립예측지표.
Objective To explore the clinical value of combined evaluation of receptor for advanced glycation end products (RAGE) and proliferation cell nuclear antigen (Ki-67) for prognosis of colon cancer.Methods A total of 160 patients with colon cancer were chosen for detection of the expression of RAGE and Ki-67.Correlations between the expression and clinicopathologic variables were analyzed.Results The expression of RAGE and Ki-67 was upgraded in colon cancer.The expression of RAGE was closely correlated with tumor size,differentiation,TNM stage and Ki-67 (P ＜0.05).Multivariate analysis showed that TNM stage (OR =1.99),Ki67 (OR =1.68),RAGE (OR =1.62),and co-expression of RAGE and Ki67 (OR =2.01) were independent prognostic indicators for survival of patients with colon cancer.Patients negative for both Ki-67 and RAGE had the longest survival,those positive for both Ki-67 and RAGE displayed shortest survival,and those positive for either occupied intermediate.Conclusion Combined evaluation of RAGE and Ki-67 expression is a valuable prognostic marker for patients with colon cancer.