CAJ | 학술논문

目的观察抗癌1号(KAI1)和组织抑制因子-1(TIMP-1)、基质金属蛋白酶-9(MMP-9)在非小细胞肺癌(NSCLC)组织中的表达,探讨它与临床生物学的关系.方法应用免疫组织化学法检测73例NSCLC、51例相应的癌旁和13例非肿瘤性肺组织的KAI1和TIMP-1、MMP-9的表达,采用x2检验和Pearson分析临床生物学行为的相关性.结果 NSCLC和癌旁非肿瘤组织中,KAII和TIMP-1阳性率(39.7％、74.0％和90.6％、37.5％)差异有统计学意义(P＜0.05),而MMP-9阳性率(79.4％和67.4％)差异无统计学意义(P＞0.05)；在NSCLC组织中,KAI1检出率与TNM分期、淋巴结转移、肿瘤类型差异有统计学意义(P＜0.05),TIMP-1、MMP-9的检出率与TNM分期、淋巴结转移差异有统计学意义(P＜0.05),三者检出率与年龄、性别无明显相关；KAI1的表达与TIMP-1、MMP-9呈负相关.结论 Al1和TIMP-1、MMP-9均与肺癌的发展转移有关.
목적 관찰항암1호(KAI1)화조직억제인자-1(TIMP-1)、기질금속단백매-9(MMP-9)재비소세포폐암(NSCLC)조직중적표체,탐토타여림상생물학적관계.방법 응용면역조직화학법검측73례NSCLC、51례상응적암방화13례비종류성폐조직적KAI1화TIMP-1、MMP-9적표체,채용x2검험화Pearson분석림상생물학행위적상관성.결과 NSCLC화암방비종류조직중,KAII화TIMP-1양성솔(39.7％、74.0％화90.6％、37.5％)차이유통계학의의(P＜0.05),이MMP-9양성솔(79.4％화67.4％)차이무통계학의의(P＞0.05)；재NSCLC조직중,KAI1검출솔여TNM분기、림파결전이、종류류형차이유통계학의의(P＜0.05),TIMP-1、MMP-9적검출솔여TNM분기、림파결전이차이유통계학의의(P＜0.05),삼자검출솔여년령、성별무명현상관；KAI1적표체여TIMP-1、MMP-9정부상관.결론 Al1화TIMP-1、MMP-9균여폐암적발전전이유관.
Objective To investigate the expression of Kang Ai1 (KAI1) and tissue inhibitor of metalloproteinase-1 (TIMP-1),matrix metalloproteinase-9 (MMP-9) in human non-small cell lung cancer (NSCLC) tissue and their correlations to clinicopathologic features of NSCLC.Methods The expression of KAI1 and TIMP-1,MMP-9 in 73 specimens of NSCLC,51 specimens of corresponding adjacent tissues,and 13 specimens of no cancerous lung tissues was assessed by using immunohistochemistry.Their correlations to clinicopathologic features were analyzed by using Chi-square test and Pearson analysis.Results The positive rate of KAI1 and TIMP-1 was significantly higher in NSCLC tissues than in adjacent tissues and no-cancerous lung tissues (39.7％ vs.90.6％,74.0％ vs.37.5％,P ＜0.05),and MMP-9 had no significant change (79.4％ vs.67.4％,P ＞ 0.05).The expression of KAI1 was correlated to TNM stage,lymph node metastasis,histologic subtype and differentiation (P ＜ 0.05),and the TIMP-1 and MMP-9were correlated to TNM stage and lymph node metastasis of NSCLC patients (P ＜ 0.05),but they not to age and sex (P ＞ 0.05).The expression of KAI1 was negatively correlated to the expression of TIMP-1 and MMP-9.Conclusion The KAI1,TIMP-1 and MMp-9 are related to development of lung cancer.