中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
2期
256-257
,共2页
胃癌%趋化因子受体%诱导型一氧化氮合酶%转移
胃癌%趨化因子受體%誘導型一氧化氮閤酶%轉移
위암%추화인자수체%유도형일양화담합매%전이
Gastric carcinoma%Chemokine receptor%Inducible nitric oxide synthase%Metastasis
目的 探讨胃癌中趋化因子受体(CXCR4)、诱导型一氧化氮合酶(iNOS)的表达及其与胃癌淋巴结转移的关系.方法 免疫组织化学SP法检测80例胃癌、癌旁组织手术切除标本CXCR4、iNOS的表达,探讨其与淋巴结转移的关系.结果 胃癌组织中CXCR4 (58.7％)和iNOS(77.5％)的蛋白表达率均明显高于癌旁组织,合并淋巴结转移的胃癌标本CXCR4 (70.8％)、iNOS(89.6％)表达明显高于无转移者(P＜0.05).结论 CXCR4和iNOS在胃癌的发生中有协同作用,两者可能共同参与肿瘤淋巴结转移.
目的 探討胃癌中趨化因子受體(CXCR4)、誘導型一氧化氮閤酶(iNOS)的錶達及其與胃癌淋巴結轉移的關繫.方法 免疫組織化學SP法檢測80例胃癌、癌徬組織手術切除標本CXCR4、iNOS的錶達,探討其與淋巴結轉移的關繫.結果 胃癌組織中CXCR4 (58.7％)和iNOS(77.5％)的蛋白錶達率均明顯高于癌徬組織,閤併淋巴結轉移的胃癌標本CXCR4 (70.8％)、iNOS(89.6％)錶達明顯高于無轉移者(P＜0.05).結論 CXCR4和iNOS在胃癌的髮生中有協同作用,兩者可能共同參與腫瘤淋巴結轉移.
목적 탐토위암중추화인자수체(CXCR4)、유도형일양화담합매(iNOS)적표체급기여위암림파결전이적관계.방법 면역조직화학SP법검측80례위암、암방조직수술절제표본CXCR4、iNOS적표체,탐토기여림파결전이적관계.결과 위암조직중CXCR4 (58.7％)화iNOS(77.5％)적단백표체솔균명현고우암방조직,합병림파결전이적위암표본CXCR4 (70.8％)、iNOS(89.6％)표체명현고우무전이자(P＜0.05).결론 CXCR4화iNOS재위암적발생중유협동작용,량자가능공동삼여종류림파결전이.
Objective To evaluate the correlation of chemokine receptor (CXCR4) and inducible nitric oxide synthase (iNOS) expression correlates with lymph node metastasis in gastric carcinoma.Methods Immunohistochemical stain was used to detect the expression of CXCR4,iNOS in 80 resected speciments of gastric carcinoma and paracancerous tissues.Results The expression of CXCR4 (58.7％),iNOS (77.5％) in gastric cancinoma were significantly increased,compared with the paracancerous tissues.Significance difference were also found in the expression indexes of CXCR4 (70.8％) and iNOS (89.6％)between those with or without lymph nodr metastasis (P ＜ 0.05).Conclusion CXCR4 and iNOS might produce a synergistic effect during the genesis of gastric carcinoma and be involved in lymph node metastasis in gastric carcinoma.
