CAJ | 학술논문

目的探讨乳腺癌的超声造影增强特征与雌激素受体(ER)和孕激素受体(PR)的相关性.方法观察45例乳腺癌的超声造影增强特征,并与乳腺癌组织中ER、PR的表达进行相关分析.结果乳腺癌造影后27例血流灌注缺损,25例向心性增强.乳腺癌的增强特征与ER的表达水平明显相关(P＜0.05),向心性增强及血流灌注缺损多发生在ER阴性肿瘤.以向心性增强判断ER表达的灵敏性为48％,特异性为85％；以血流灌注缺损判断ER表达的灵敏性为48.1％,特异性为88.9％.乳腺癌的增强特征与PR的表达水平无明显相关(P＞0.05).结论乳腺癌超声造影增强特征与ER的表达水平相关.
목적 탐토유선암적초성조영증강특정여자격소수체(ER)화잉격소수체(PR)적상관성.방법 관찰45례유선암적초성조영증강특정,병여유선암조직중ER、PR적표체진행상관분석.결과 유선암조영후27례혈류관주결손,25례향심성증강.유선암적증강특정여ER적표체수평명현상관(P＜0.05),향심성증강급혈류관주결손다발생재ER음성종류.이향심성증강판단ER표체적령민성위48％,특이성위85％；이혈류관주결손판단ER표체적령민성위48.1％,특이성위88.9％.유선암적증강특정여PR적표체수평무명현상관(P＞0.05).결론 유선암초성조영증강특정여ER적표체수평상관.
Objective To investigate the correlation between enhancement characteristics of contrast-enhanced ultrasound (CEUS) with estrogen receptor (ER) and progesterone receptor (PR) expression in breast cancer.Methods The enhancement characteristics of 45 breast cancers at CEUS were analyzed.The SP immunohistochemical staining was performed to identify the ER and PR expression.Correlation of ER and PR expression with enhancement features was analyzed with the Pearson (x)2 test.Results The malignancies displayed local blood perfusion defect in 27 cases,and centripetal enhancement in 25 cases.Some enhancement features were associated with ER expression (P ＜ 0.05).Perfusion defect and centripetal enhancement were more common in negative ER expression group than in positive ER expression.The sensitivity and specificity of centripetal enhancement for detecting the ER expression were 48％ and 85％,respectively,and the sensitivity and specificity of perfusion defect for detecting ER expression were 48.1％ and 88.9％,respectively.However,the enhancement characteristics of CEUS showed no significant correlation with PR expression (P ＞ 0.05).Conclusion The enhancement characteristics of CEUS were associated with ER expression.