CAJ | 학술논문

目的检测尿透明质酸(HA)、透明质酸酶1(HYAL1)在预测无浸润膀胱肿瘤的复发和肌肉浸润中的作用.方法随访144个膀胱肿瘤患者(110个无肌肉浸润者、34个肌肉浸润者),检测患者尿液HA和HYAL1水平,膀胱癌复发和浸润的HA、HYAL1联合检测是由单因素和多因素模型完成的.结果在非浸润性膀胱癌患者尿标本中,有复发或浸润的患者HYAL1的水平较高(210.6±68.4、240.3±62.2),比较无复发或浸润的患者HYAL1的表达则为(168.5 ±6.6、210.4±7.9,P＞0.05).在多因素分析中,HYAL1与复发(敏感度59.6％,P＜0.05)和肌肉浸润(敏感度76.8％,P＜0.01)均有相关.结论 HA、HYAL1可能是膀胱癌术后监测复发或肌肉浸润潜在的肿瘤标志物.
목적 검측뇨투명질산(HA)、투명질산매1(HYAL1)재예측무침윤방광종류적복발화기육침윤중적작용.방법 수방144개방광종류환자(110개무기육침윤자、34개기육침윤자),검측환자뇨액HA화HYAL1수평,방광암복발화침윤적HA、HYAL1연합검측시유단인소화다인소모형완성적.결과 재비침윤성방광암환자뇨표본중,유복발혹침윤적환자HYAL1적수평교고(210.6±68.4、240.3±62.2),비교무복발혹침윤적환자HYAL1적표체칙위(168.5 ±6.6、210.4±7.9,P＞0.05).재다인소분석중,HYAL1여복발(민감도59.6％,P＜0.05)화기육침윤(민감도76.8％,P＜0.01)균유상관.결론 HA、HYAL1가능시방광암술후감측복발혹기육침윤잠재적종류표지물.
Objective To evaluate whether hyaluronic acid (HA) and hyaluronoglucosaminidase 1 (HYAL1) can predict progression to muscle invasion and recurrence among patients with non-muscle-invasive bladder cancer.Methods There were 144 cases of bladder cancer who were followed up,including 110 cases of non-muscle-invasive bladder and 34 cases of muscle-invasive bladder cancer.Combined detection of HA and HYAL1 for bladder cancer recurrence and muscle invasion was done by using univariate and multivariate models.Results In non-muscle-invasive bladder cancer specimens,during the course of disease,HYAL1 level was higher (210.6 ±68.4,240.3 ±62.2) in patients with muscle invasion or recurrence than in patients without invasion or recurrence (168.5 ± 6.6,210.4 ± 7.9,P ＞ 0.05).Multivariate analysis revealed that HYAL1 was significantly correlated with recurrence (59.6％ sensitivity,P ＜ 0.05)and muscle invasion (76.8％ sensitivity,P ＜ 0.05).Conclusion HYAL1 is probalblely an independent marker in predicting progression to muscle invasion and recurrence in bladder cancer.