中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
7期
1511-1513
,共3页
胃癌%p53蛋白%血管内皮生长因子
胃癌%p53蛋白%血管內皮生長因子
위암%p53단백%혈관내피생장인자
Gastric cancer%p53%Vascular endothelial growth factor
目的 探讨p53和血管内皮生长因子(VEGF)在胃癌组织中的表达与胃癌临床病理特征之间的关系.方法 收集山东省滨州市人民医院2007年6月至2012年2月经手术切除且病理证实的83例胃癌病例,记录患者性别、年龄、胃癌分化程度、浸润程度、淋巴结转移及TNM分期等各项临床相关资料,观察病理大体及镜下特点,行免疫组织化学染色,检测p53和VEGF在胃癌组织中的表达.结果 p53蛋白在胃癌组织中的表达阳性率为43.37％(36例),p53蛋白阳性表达与分化程度、有无淋巴结转移有关.VEGF在胃癌组织中的表达阳性率为69.88％(58例),VEGF阳性表达与浸润深度、淋巴结是否转移及TNM分期有关(P＜0.05).结论 联合检测p53和VEGF在胃癌组织中的表达有助于对胃癌的临床诊断、病情、治疗及预后进行评估.
目的 探討p53和血管內皮生長因子(VEGF)在胃癌組織中的錶達與胃癌臨床病理特徵之間的關繫.方法 收集山東省濱州市人民醫院2007年6月至2012年2月經手術切除且病理證實的83例胃癌病例,記錄患者性彆、年齡、胃癌分化程度、浸潤程度、淋巴結轉移及TNM分期等各項臨床相關資料,觀察病理大體及鏡下特點,行免疫組織化學染色,檢測p53和VEGF在胃癌組織中的錶達.結果 p53蛋白在胃癌組織中的錶達暘性率為43.37％(36例),p53蛋白暘性錶達與分化程度、有無淋巴結轉移有關.VEGF在胃癌組織中的錶達暘性率為69.88％(58例),VEGF暘性錶達與浸潤深度、淋巴結是否轉移及TNM分期有關(P＜0.05).結論 聯閤檢測p53和VEGF在胃癌組織中的錶達有助于對胃癌的臨床診斷、病情、治療及預後進行評估.
목적 탐토p53화혈관내피생장인자(VEGF)재위암조직중적표체여위암림상병리특정지간적관계.방법 수집산동성빈주시인민의원2007년6월지2012년2월경수술절제차병리증실적83례위암병례,기록환자성별、년령、위암분화정도、침윤정도、림파결전이급TNM분기등각항림상상관자료,관찰병리대체급경하특점,행면역조직화학염색,검측p53화VEGF재위암조직중적표체.결과 p53단백재위암조직중적표체양성솔위43.37％(36례),p53단백양성표체여분화정도、유무림파결전이유관.VEGF재위암조직중적표체양성솔위69.88％(58례),VEGF양성표체여침윤심도、림파결시부전이급TNM분기유관(P＜0.05).결론 연합검측p53화VEGF재위암조직중적표체유조우대위암적림상진단、병정、치료급예후진행평고.
Objective To analyze the relationship between p53 and vascular endothelial growth factor (VEGF) expression in gastric cancer and clinicalfeatures of gastric cancer.Methods Eighty-three cases of gastric cancer surgically resected and pathologically confirmed were collected,and the clinical data including gender,age,differentiation degree,invasion,lymph node metastasis and TNM stages were recorded and analyzed.The p53 and VEGF expression was detected by using immunohistochemistry and analyzed by using SPSS 14.0 statistical software.Results The poitive expression rate of p53 in gastric cancer was 61.44％ (51 cases).The p53 gene expression was positively correlated with the differentiation degree and lymphaden metastases.The positive expression rate of VEGF expression in gastric cancer was 69.88％ (58 cases),and the VEGF expression was positively correlated with the invasive extension,lymphaden metastases and TNM stages.Conclusion Combined detection of the expression of p53 and VEGF in gastric cancer contributes to the clinical diagnosis,illness evaluation,treatment and prognosis of gastric cancer.
