CAJ | 학술논문

目的探讨上皮细胞黏附因子(EpCAM)在结直肠癌中的表达及其临床意义,探讨其表达与β-连环蛋白(β-catenin)表达的相关性.方法应用免疫组织化学法检测120例结直肠癌组织和30例正常结直肠组织中EpCAM的表达,同时在120例结直肠癌组织中检测β-catenin的表达,结合临床病理特征及随访资料进行统计学分析.结果 EpCAM在结直肠癌组织中的高表达率约为60.8％,明显高于正常结直肠组织(6.7％,P＜0.01)；EpCAM在结直肠癌组织中的表达与TMN分期、淋巴结转移、远处转移及复发密切相关(P＜0.05). β-catenin在结直肠癌的高表达率约为70.0％,其表达与EpCAM的表达呈显著正相关(r=0.518,P＜0.01).生存分析表明结直肠癌患者的预后与EpCAM的表达、淋巴结转移、远处转移及复发密切相关(P＜0.05)；多因素分析表明EpCAM、TNM分期及淋巴结转移可作为结直肠癌患者的独立预后因素.结论 EpCAM在结直肠癌中的表达与β-catenin的表达呈明显正相关.
목적 탐토상피세포점부인자(EpCAM)재결직장암중적표체급기림상의의,탐토기표체여β-련배단백(β-catenin)표체적상관성.방법 응용면역조직화학법검측120례결직장암조직화30례정상결직장조직중EpCAM적표체,동시재120례결직장암조직중검측β-catenin적표체,결합림상병리특정급수방자료진행통계학분석.결과 EpCAM재결직장암조직중적고표체솔약위60.8％,명현고우정상결직장조직(6.7％,P＜0.01)；EpCAM재결직장암조직중적표체여TMN분기、림파결전이、원처전이급복발밀절상관(P＜0.05). β-catenin재결직장암적고표체솔약위70.0％,기표체여EpCAM적표체정현저정상관(r=0.518,P＜0.01).생존분석표명결직장암환자적예후여EpCAM적표체、림파결전이、원처전이급복발밀절상관(P＜0.05)；다인소분석표명EpCAM、TNM분기급림파결전이가작위결직장암환자적독립예후인소.결론 EpCAM재결직장암중적표체여β-catenin적표체정명현정상관.
Objective To investigate the expression and clinical significance of epithelial cell adhesion molecule (EpCAM),and its correlation with β-catenin in colorectal cancer.Methods Immunohistochemical method was used to detect the EpCAM expression in 120 cases of colorectal cancer and 30 cases of normal colorectal tissues,and meanwhile detect the β-catenin expression in 120 cases of colorectal cancer tissues.The results combined with clinicopathological features and follow-up data were analyzed statistically.Results The rate of high EpCAM expression in colorectal carcinoma tissue (60.8％) was obviously higher than that in normal colorectal tissue (6.7％,P ＜ 0.01).The expression of EpCAM in colorectal carcinoma tissue was associated with TMN stages,lymph node metastasis,distant metastasis and recurrence (P ＜ 0.05).The rate of high β-catenin expression in colorectal carcinoma tissue was 70％,and significantly correlated with the expression of EpCAM (r =0.518,P ＜ 0.01).Survival analysis showed that the prognosis of patients with colorectal cancer was associated with EpCAM expression,lymph node metastasis,distant metastasis and recurrence (P ＜ 0.05).Multiple factor analysis showed that EpCAM,TNM stages and lymph node metastasis could be used as independent prognostic factors for colorectal cancer patients.Conclusion The EpCAM expression has a significantly positive correlation with the β-catenin expression in colorectal cancer.