CAJ | 학술논문

目的探讨EZH2和桩蛋白(Paxillin)与结直肠癌临床病理参数及预后的关系.方法 ()疫组织化学法检测85例结直肠癌患者手术切除的肿瘤组织和配对癌旁组织中EZH2和Paxillin表达水平.结果 EZH2在结直肠癌组织中表达率为74.12％(63/85),在癌旁组织中表达率为45.88％ (39/85),两者差异有统计学意义(P＜0.01),EZH2表达水平与结直肠癌组织学分化程度、TNM分期、淋巴结转移有关(P＜0.05)；Paxillin在结直肠癌组织中表达率为56.47％ (48/85),在癌旁组织中表达率为21.18％ (18/85),两者差异有统计学意义(P＜0.01),Paxillin表达水平与结直肠癌组织学分化程度、TNM分期、淋巴结转移有关(P＜0.05).结论 EZH2和Paxillin检测有助于评估结直肠癌恶性程度及预后.
목적 탐토EZH2화장단백(Paxillin)여결직장암림상병리삼수급예후적관계.방법 ()역조직화학법검측85례결직장암환자수술절제적종류조직화배대암방조직중EZH2화Paxillin표체수평.결과 EZH2재결직장암조직중표체솔위74.12％(63/85),재암방조직중표체솔위45.88％ (39/85),량자차이유통계학의의(P＜0.01),EZH2표체수평여결직장암조직학분화정도、TNM분기、림파결전이유관(P＜0.05)；Paxillin재결직장암조직중표체솔위56.47％ (48/85),재암방조직중표체솔위21.18％ (18/85),량자차이유통계학의의(P＜0.01),Paxillin표체수평여결직장암조직학분화정도、TNM분기、림파결전이유관(P＜0.05).결론 EZH2화Paxillin검측유조우평고결직장암악성정도급예후.
Objective To study the relationship between of enhancer of zest homolog 2 (EZH2) and Paxillin with clinical and pathological characteristics in colorectal carcinoma.Methods Immunohistochemical method was used to assess the expression of EZH2 and Paxillin in 85 cases of human colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of EZH2 was 74.12％ (63/85) in colorectal carcinoma tissues,and 45.88％ (39/85) in non-cancerous adjacent colorectal tissues (P ＜0.01).The expression levels of EZH2 were related to histological grade,TNM stage and lymph node metastasis (P ＜ 0.05).The expression rate of Paxillin was 56.47％ (48/85) in colorectal carcinoma tissues,and 21.18％ (18/85) in non-cancerous adjacent colorectal tissues (P ＜ 0.01).There was a close relation between the expression of Paxillin and histological grade,serosa invasion,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion EZH2 and Paxillin may be used as markers for malignance degree and poor prognosis of colorectal carcinoma.