CAJ | 학술논문

目的观察高压氧(HBO)同步联合放化疗治疗与单纯放化疗对胶质瘤术后患者的疗效、生存质量比较.方法治疗组为脑恶性胶质瘤32例经开颅显微手术后行高压氧联合放化疗治疗；对照组为脑恶性胶质瘤31例术后单纯行放化疗.结果行治疗组和对照组总有效率[完全缓解(CR)+部分缓解(PR)]分别为93.75％、71.49％ (P ＜0.05)；两组Ⅱ、Ⅱ～Ⅲ、Ⅲ～Ⅳ级不同病理级别患者治疗后6个月ADL量表分值分别为:(18.18±3.63)、(22.89±5.71)分；(20.69±4.17)、(25.47±6.36)分及(26.20±7.36)、(36.86±8.21)分(P＜0.05),治疗组患者生存质量明显提高.结论显微手术后高压氧联合放化疗治疗脑恶性胶质瘤疗效较好.
목적 관찰고압양(HBO)동보연합방화료치료여단순방화료대효질류술후환자적료효、생존질량비교.방법 치료조위뇌악성효질류32례경개로현미수술후행고압양연합방화료치료；대조조위뇌악성효질류31례술후단순행방화료.결과 행치료조화대조조총유효솔[완전완해(CR)+부분완해(PR)]분별위93.75％、71.49％ (P ＜0.05)；량조Ⅱ、Ⅱ～Ⅲ、Ⅲ～Ⅳ급불동병리급별환자치료후6개월ADL량표분치분별위:(18.18±3.63)、(22.89±5.71)분；(20.69±4.17)、(25.47±6.36)분급(26.20±7.36)、(36.86±8.21)분(P＜0.05),치료조환자생존질량명현제고.결론 현미수술후고압양연합방화료치료뇌악성효질류료효교호.
Objective To compare the short-term therapeutic effectiveness,survival duration and quality of life between patients receiving chemoradiotherapy combined with inhalation of hyperbaric oxygen therapy (HBO) vs.chemoradiotherapy alone in postoperative patients with malignant gliomas.Methods A total of 63 patients by initial operative treatment with malignant gliomas were analyzed.All patients were divided into two groups:chemoradiotherapy combined with inhalation of HBO group (n =32) and chemoradiotherapy group (n =31).Results The effective rate of total symptoms improved (CR and PR) in the chemoradiotherapy combined with inhalation of HBO group and chemoradiotherapy group was 93.75％ and 71.49％ respectively (P ＜0.05).Activities of daily living (ADL) scale of grades Ⅱ,Ⅱ-Ⅲ,Ⅲ-Ⅳ was assessed on all patients after the treatment.On the 6th month after treatment,ADL scales of grades Ⅱ,Ⅱ-Ⅲ and Ⅲ-Ⅳ in chemoradiotherapy combined with inhalation of HBO group and chemoradiotherapy group were 18.18 ±3.63,22.89 ±5.71 ; 20.69 ±4.17,25.47 ±6.36; and 26.20 ±7.36,36.86 ±8.21 respectively (P ＜ 0.05 for all),and the life quality of patients was improved obviously.Conclusion Microsurgical resection combined with chemoradiotherapy and inhalation of HBO is a safe and effective method for gliomas.