中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
10期
2060-2063
,共4页
易晓雷%李旭辉%汪杰%苗雄鹰%梁昊
易曉雷%李旭輝%汪傑%苗雄鷹%樑昊
역효뢰%리욱휘%왕걸%묘웅응%량호
内皮细胞分化基因-1%丝切蛋白-1%癌,肝细胞%预后
內皮細胞分化基因-1%絲切蛋白-1%癌,肝細胞%預後
내피세포분화기인-1%사절단백-1%암,간세포%예후
Endothelial differentiation gene 1%Cofilin-1%Carcinoma,hepatocellular%Prognosis
目的 探讨内皮细胞分化基因-1(EDG-1)、丝切蛋白-1(CFL-1)在原发性肝细胞癌(HCC)中的表达水平及其与临床病理特征和两者之间的相互关系.方法 采用免疫组织化学方法,检测EDG-1、CFL-1在57例原发性肝细胞癌组织(实验组)及15例癌旁组织(对照组)中的表达,并与临床病理资料进行比较分析.随访所有病例术后的生存时间,并进行生存分析.结果 EDG-1 、CFL-1阳性表达分别为54.4% (31/57)和66.7% (37/57),均明显高于正常肝组织的表达,差异有统计学意义(P<0.05),且呈正相关(P<0.05).EDG-1、CFL-1在肿瘤转移组及低分化组中的表达阳性率明显高于无肿瘤转移组及高+中分化组,差异有统计学意义(P<0.05).COX多因素回归分析的结果提示,肿瘤转移、癌栓、病理分型、EDG-1及CFL-1的表达为影响预后的独立因素.结论 EDG-1 、CFL-1可能作为判断HCC恶性程度的预测指标,其表达水平有助于评价肝细胞癌患者的预后.
目的 探討內皮細胞分化基因-1(EDG-1)、絲切蛋白-1(CFL-1)在原髮性肝細胞癌(HCC)中的錶達水平及其與臨床病理特徵和兩者之間的相互關繫.方法 採用免疫組織化學方法,檢測EDG-1、CFL-1在57例原髮性肝細胞癌組織(實驗組)及15例癌徬組織(對照組)中的錶達,併與臨床病理資料進行比較分析.隨訪所有病例術後的生存時間,併進行生存分析.結果 EDG-1 、CFL-1暘性錶達分彆為54.4% (31/57)和66.7% (37/57),均明顯高于正常肝組織的錶達,差異有統計學意義(P<0.05),且呈正相關(P<0.05).EDG-1、CFL-1在腫瘤轉移組及低分化組中的錶達暘性率明顯高于無腫瘤轉移組及高+中分化組,差異有統計學意義(P<0.05).COX多因素迴歸分析的結果提示,腫瘤轉移、癌栓、病理分型、EDG-1及CFL-1的錶達為影響預後的獨立因素.結論 EDG-1 、CFL-1可能作為判斷HCC噁性程度的預測指標,其錶達水平有助于評價肝細胞癌患者的預後.
목적 탐토내피세포분화기인-1(EDG-1)、사절단백-1(CFL-1)재원발성간세포암(HCC)중적표체수평급기여림상병리특정화량자지간적상호관계.방법 채용면역조직화학방법,검측EDG-1、CFL-1재57례원발성간세포암조직(실험조)급15례암방조직(대조조)중적표체,병여림상병리자료진행비교분석.수방소유병례술후적생존시간,병진행생존분석.결과 EDG-1 、CFL-1양성표체분별위54.4% (31/57)화66.7% (37/57),균명현고우정상간조직적표체,차이유통계학의의(P<0.05),차정정상관(P<0.05).EDG-1、CFL-1재종류전이조급저분화조중적표체양성솔명현고우무종류전이조급고+중분화조,차이유통계학의의(P<0.05).COX다인소회귀분석적결과제시,종류전이、암전、병리분형、EDG-1급CFL-1적표체위영향예후적독립인소.결론 EDG-1 、CFL-1가능작위판단HCC악성정도적예측지표,기표체수평유조우평개간세포암환자적예후.
Objective To explore the correlation between the expression of endothelial differentiation gene 1 (EDG-1) and cofilin-1 (CFL-1) in hepatocellular carcinoma (HCC) with clinicopathological characteristics.Methods Immunohistochemistry was applied to detect the differential expression of EDG-1 and CFL-1 in 57 tumor specimens (experimental group) and 15 paracancerous hepatic tissue specimens (control group).The survival time of all cases after surgery was followed up.Results The immunohistochemistry showed that immunostaining of EDG-1 and CFL-1 was located in the cytoplasm,and the positive rate was 54.4% (31/57) and 66.7% (38/57) respectively in experimental group,significantly higher than 13.3% (2/15) in control group (both P < 0.05).There was a positive correlation between the expression score of EDG-1 and CFL-1 in HCC tissues (P < 0.05).The clinicopathological evaluation revealed that the expression of EDG-1 and CFL-1 was significantly higher in HCC cases with metastasis than in those without metastasis (P < 0.05),and correlated with differentiation degree of HCC tissues (P <0.05).Cox regression analysis showed that metastasis,cancer embolus,differentiation degree and the expression of EDG-1 and CFL-1 were independent prognostic factors (P < 0.05).Conclusion EDG-1 andCFL-1 could be an indication to identify the malignant degree of HCC.EDG-1 and CFL-1 are likely to be valuable indications in evaluating of the prognosis of patients with HCC.