中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
10期
2206-2208
,共3页
丁敏勇%梅祎军%周子花%毛茅%李春孟%王理富
丁敏勇%梅祎軍%週子花%毛茅%李春孟%王理富
정민용%매의군%주자화%모모%리춘맹%왕리부
良性结肠肿瘤%恶性结肠肿瘤%转移性肿瘤%Ⅰ型胶原吡啶交联终肽
良性結腸腫瘤%噁性結腸腫瘤%轉移性腫瘤%Ⅰ型膠原吡啶交聯終肽
량성결장종류%악성결장종류%전이성종류%Ⅰ형효원필정교련종태
Benign carcinomaofrectum%Primary carcinomaofrectum%Metastatic tumor%Pyridinoline cross linked carboxyterminal telopeptide of type Ⅰ collagen
目的 检测良性结肠肿瘤、恶性结肠肿瘤患者及健康对照组血清中的Ⅰ型胶原吡啶交联终肽(ICTP)活性,探讨ICTP在良恶性结肠肿瘤诊断和鉴别诊断中的价值.方法 选取75例恶性胃肠肿瘤患者,设为A组,其中71例为原发性恶性结肠肿瘤、4例为转移性肿瘤患者,另选43例良性结肠肿瘤患者为B组,同时,设52例同龄健康人为C组,均采用酶免疫测定(EIA)方法测定血清中的ICTP活性.结果 B组患者血清ICTP活性为(6.75 ±3.34) μg/L,C组血清ICTP活性为(4.68±2.91) μg/L,A组患者血清ICTP活性为(14.84±8.49) μg/L,其中,原发性恶性结肠肿瘤患者和转移性结肠肿瘤患者的血清ICTP活性分别为(17.47±10.86) μg/L和(8.14 ±5.45) μg/L.A组中两类患者的血清ICTP活性与B、C组比较差异均有统计学意义(P＜0.05),B组患者与C组比较差异无统计学意义(P＞0.05).而A组中原发性恶性结肠肿瘤与转移性肿瘤组之间的差异也有统计学意义(P＜0.05).结论 血清ICTP是反映结肠肿瘤骨代谢的一个灵敏而简便的检测指标,并有助于良恶性结肠肿瘤的诊断及鉴别诊断.
目的 檢測良性結腸腫瘤、噁性結腸腫瘤患者及健康對照組血清中的Ⅰ型膠原吡啶交聯終肽(ICTP)活性,探討ICTP在良噁性結腸腫瘤診斷和鑒彆診斷中的價值.方法 選取75例噁性胃腸腫瘤患者,設為A組,其中71例為原髮性噁性結腸腫瘤、4例為轉移性腫瘤患者,另選43例良性結腸腫瘤患者為B組,同時,設52例同齡健康人為C組,均採用酶免疫測定(EIA)方法測定血清中的ICTP活性.結果 B組患者血清ICTP活性為(6.75 ±3.34) μg/L,C組血清ICTP活性為(4.68±2.91) μg/L,A組患者血清ICTP活性為(14.84±8.49) μg/L,其中,原髮性噁性結腸腫瘤患者和轉移性結腸腫瘤患者的血清ICTP活性分彆為(17.47±10.86) μg/L和(8.14 ±5.45) μg/L.A組中兩類患者的血清ICTP活性與B、C組比較差異均有統計學意義(P＜0.05),B組患者與C組比較差異無統計學意義(P＞0.05).而A組中原髮性噁性結腸腫瘤與轉移性腫瘤組之間的差異也有統計學意義(P＜0.05).結論 血清ICTP是反映結腸腫瘤骨代謝的一箇靈敏而簡便的檢測指標,併有助于良噁性結腸腫瘤的診斷及鑒彆診斷.
목적 검측량성결장종류、악성결장종류환자급건강대조조혈청중적Ⅰ형효원필정교련종태(ICTP)활성,탐토ICTP재량악성결장종류진단화감별진단중적개치.방법 선취75례악성위장종류환자,설위A조,기중71례위원발성악성결장종류、4례위전이성종류환자,령선43례량성결장종류환자위B조,동시,설52례동령건강인위C조,균채용매면역측정(EIA)방법측정혈청중적ICTP활성.결과 B조환자혈청ICTP활성위(6.75 ±3.34) μg/L,C조혈청ICTP활성위(4.68±2.91) μg/L,A조환자혈청ICTP활성위(14.84±8.49) μg/L,기중,원발성악성결장종류환자화전이성결장종류환자적혈청ICTP활성분별위(17.47±10.86) μg/L화(8.14 ±5.45) μg/L.A조중량류환자적혈청ICTP활성여B、C조비교차이균유통계학의의(P＜0.05),B조환자여C조비교차이무통계학의의(P＞0.05).이A조중원발성악성결장종류여전이성종류조지간적차이야유통계학의의(P＜0.05).결론 혈청ICTP시반영결장종류골대사적일개령민이간편적검측지표,병유조우량악성결장종류적진단급감별진단.
Objective To investigate the clinical usefulness of determination of serum pyridinoline cross linked carboxyterminal telopeptide of type Ⅰ collagen (ICTP) in patients with carcinomaofrectum.Methods 75 malignant carcinomaofrectum patients in group A with 71 primary malignant carcinomaofrecrum patients and 4 metastatic carcinomaofrectum patients were analyzed,43 benign carcinomaofrectum patients were including group B,52 normal persons were chosen in group C,Serum ICTP in everybody was determined by enzyme immunoassay (EIA).Results The serum level of ICTP in group A was (14.84 ±8.49) μg/L,and the serum level of primary malignant carcinomaofrectum,and metastatic tumor of bone in group A were (17.47 ± 10.86) μg/L and (8.14 ± 5.45) μg/L,the serum level of ICTP in group B and C were (6.75 ±3.34) μg/L and (4.68 ±2.91) μg/L.The serum level in group A was significantly higher than that in group B and C (P ＜ 0.05),At the same time,the serum level in primary malignant carcinomaofrectum patients were significantly higher than that of metastatic carcinomaofrectum patients (P ＜ 0.05).Conclusion Serum ICTP was a sensitive and convenient biochemical index which could diagnose and identify carcinomaofrectum.
