CAJ | 학술논문

目的观察波形蛋白在非小细胞肺癌(NSCLC)患者的表达及其对肿瘤转移的预测作用.方法使用免疫组织化学法检测164例鳞状细胞癌、108例腺癌以及其他23例其他NSCLC患者波形蛋白的表达.结果波形蛋白在上述患者中的总检出率为49.2％,主要在肿瘤/间质表面表达,与肿瘤的分化状态密切相关.随访患者表明,＞50％肿瘤细胞表达波形蛋白的患者均出现肿瘤转移.结论波形蛋白在NSCLC患者体内有表达,它的表达与患者的肿瘤转移呈明显正相关.
목적 관찰파형단백재비소세포폐암(NSCLC)환자적표체급기대종류전이적예측작용.방법 사용면역조직화학법검측164례린상세포암、108례선암이급기타23례기타NSCLC환자파형단백적표체.결과 파형단백재상술환자중적총검출솔위49.2％,주요재종류/간질표면표체,여종류적분화상태밀절상관.수방환자표명,＞50％종류세포표체파형단백적환자균출현종류전이.결론 파형단백재NSCLC환자체내유표체,타적표체여환자적종류전이정명현정상관.
Objective To examine vimentin expression in non-small cell lung carcinomas (NSCLC) by using immunohistochemistry to evaluate potential correlations between vimentin expression and the metastase of the patients.Methods 295 cases of NSCLC including 164 cases of squamous cell carcinomas (SCC),108 cases of adenocarcinomas (AC) and 23 cases of other NSCLC carcinomas were examined by using immunohistochemistry.Results Vimentin was indeed detected in 145 cases (49.2％).It was principally present in cells at the tumour/stroma interface.Vimentin expression was significantly associated with the differentiation status of carcinomas.The follow-up of patients further demonstrated that an extensive expression of vimentin (＞50％ of tumour cells) was associated with the occurrence of metastases.Conclusion Our data demonstrate that vimentin expression is a frequent event in NSCLC and that its expression can be associated with the occurrence of metastases positively.