中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
12期
2714-2716,封4
,共4页
李钰泉%周天骏%潘越江%李玉东%金柯%张惠忠
李鈺泉%週天駿%潘越江%李玉東%金柯%張惠忠
리옥천%주천준%반월강%리옥동%금가%장혜충
非小细胞肺癌%Notch1%Notch3%预后
非小細胞肺癌%Notch1%Notch3%預後
비소세포폐암%Notch1%Notch3%예후
Non-small cell lung cancer%Notch1%Notch3%Prognosis
目的 探讨Notch1和Notch3在非小细胞肺癌(NSCLC)组织中的表达及其与患者预后的关系.方法 对60例NSCLC患者,应用免疫组织化学技术检测Notch1和Notch3在其肺癌组织及正常肺组织中的表达,分析其与患者临床病理特征及术后生存时间的相关性.结果 Notch1和Notch3在肺癌组织中的阳性率(73.3％和76.7％)明显高于正常肺组织(30.0％和26.7％,P＜0.05).Notch1的表达水平与肿瘤病理分期、淋巴结转移明显相关(P＜0.05);Notch3的表达水平与淋巴结转移明显相关(P＜0.05).Kaplan-Meier生存分析显示,Notch1和Notch3阴性组患者预后明显优于阳性组.多因素分析显示Notch1和Notch3是影响NSCLC患者预后的独立危险因素.结论 Notch1和Notch3的表达水平影响NSCLC组织的临床病理特征进而影响患者的预后.
目的 探討Notch1和Notch3在非小細胞肺癌(NSCLC)組織中的錶達及其與患者預後的關繫.方法 對60例NSCLC患者,應用免疫組織化學技術檢測Notch1和Notch3在其肺癌組織及正常肺組織中的錶達,分析其與患者臨床病理特徵及術後生存時間的相關性.結果 Notch1和Notch3在肺癌組織中的暘性率(73.3％和76.7％)明顯高于正常肺組織(30.0％和26.7％,P＜0.05).Notch1的錶達水平與腫瘤病理分期、淋巴結轉移明顯相關(P＜0.05);Notch3的錶達水平與淋巴結轉移明顯相關(P＜0.05).Kaplan-Meier生存分析顯示,Notch1和Notch3陰性組患者預後明顯優于暘性組.多因素分析顯示Notch1和Notch3是影響NSCLC患者預後的獨立危險因素.結論 Notch1和Notch3的錶達水平影響NSCLC組織的臨床病理特徵進而影響患者的預後.
목적 탐토Notch1화Notch3재비소세포폐암(NSCLC)조직중적표체급기여환자예후적관계.방법 대60례NSCLC환자,응용면역조직화학기술검측Notch1화Notch3재기폐암조직급정상폐조직중적표체,분석기여환자림상병리특정급술후생존시간적상관성.결과 Notch1화Notch3재폐암조직중적양성솔(73.3％화76.7％)명현고우정상폐조직(30.0％화26.7％,P＜0.05).Notch1적표체수평여종류병리분기、림파결전이명현상관(P＜0.05);Notch3적표체수평여림파결전이명현상관(P＜0.05).Kaplan-Meier생존분석현시,Notch1화Notch3음성조환자예후명현우우양성조.다인소분석현시Notch1화Notch3시영향NSCLC환자예후적독립위험인소.결론 Notch1화Notch3적표체수평영향NSCLC조직적림상병리특정진이영향환자적예후.
Objective To assess the expression of Notch1 and Notch3 in non-small cell lung cancer (NSCLC) patients and determine its association with prognosis.Methods Immunohistochemistry was uesd to detect Notch1 and Notch3 expression in NSCLC tissues and adjacent non-cancerous normal lung tissues from 60 patients undergoing surgical treatment.The correlation between the expression levels of Notch1 and Notch3 with clinicopathological features and postoperative survival time was analyzed.Results The positive expression rate of Notch1 and Notch3 (73.3％ and 76.7％) in NSCLC tissues was significantly higher than that in normal lung tissues (30.0％ and 26.7％,P ＜ 0.05).Moreover,Notch1 overexpression was significantly correlated with TNM stage (P ＜ 0.05) and lymph node metastasis (P ＜ 0.05).Notch3 overexpression was significantly correlated with lymph node metastasis (P ＜ 0.05).Kaplan-Meier survival analysis showed that the overall survival time of Notch1-positive and Notch3-positive patients was shorter.Multivariate analysis further demonstrated that Notch1 and Notch3 were independent prognostic factors for patients with NSCLC.Conclusion Notch1 and Notch3 may be related with the clinicopathologic features of NSCLC tissues and useful biomarkers to predict the prognosis of patients with NSCLC.
