CAJ | 학술논문

目的检测肺泡Ⅱ型上皮细胞抗原(KL-6)黏蛋白(Mucin)在胰腺导管癌中的表达水平,探讨其在胰腺癌诊断和预后评估中的临床意义.方法 38例胰腺癌患者标本采用免疫组织化学染色的方法检测胰腺癌组织标本KL-6 Mucin的表达.结果 38例胰腺导管癌标本的免疫组织化学结果显示,KL-6 Mucin均呈阳性表达(100％),78.9％表达为强阳性,72.3％的癌周胰腺组织未见KL-6 Mucin的强阳性表达.KL-6 Mucin的阳性表达与肿瘤的发展与分化呈正相关.结论胰腺导管癌中KL-6 Mucin多呈强阳性表达,而癌周胰腺组织内表达不明显,这表明KL-6 Mucin和胰腺癌的浸润行为相关.
목적 검측폐포Ⅱ형상피세포항원(KL-6)점단백(Mucin)재이선도관암중적표체수평,탐토기재이선암진단화예후평고중적림상의의.방법 38례이선암환자표본채용면역조직화학염색적방법검측이선암조직표본KL-6 Mucin적표체.결과 38례이선도관암표본적면역조직화학결과현시,KL-6 Mucin균정양성표체(100％),78.9％표체위강양성,72.3％적암주이선조직미견KL-6 Mucin적강양성표체.KL-6 Mucin적양성표체여종류적발전여분화정정상관.결론 이선도관암중KL-6 Mucin다정강양성표체,이암주이선조직내표체불명현,저표명KL-6 Mucin화이선암적침윤행위상관.
Objective To investigate the expression of KL-6 mucin in pancreatic ducatal tissue,and to explore its clinical significance.Methods All specimens form 38 patients who were diagnosed as pancreatic ductal adenocarcinoma were subjected to immunohistochemical analysis using KL-6 monoclonal antibody.Results 100％ specimens of pancreatic adenocarcinoma were found positive staining,and marked positive staining was 78.9％,remarkable positive staining was not found in the surrounding noncancer regions of the pancreatic tissues (72.3％).KL-6 mucin expression was statistical significance with the tumor development and differentiation.Conclusion Most of all pancreatic adenocarcinoma cases showed remarkable positive staining for KL-6 mucin,while the majority of surrounding non-cancer regions did not.The aberrant expression of KL-6 mucin is significantly related to aggressive tumor behaviors of pancreatic adenocarcinoma.KL-6 mucin may be a specific target to detect the pancreatic adenocarcinoma in molecular imaging study.