CAJ | 학술논문

目的探讨乙二醛酶1(GL01)在肝癌中的表达及其意义.方法应用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶(SP)法检测20例正常肝组织及102例原发性肝癌组织中GL01的表达,探讨肝癌中GLOI表达与临床病理特征及预后的关系.结果 GL01在肝癌组织中的表达率为76.5％,明显高于正常肝组织(0％),差异有统计学意义(P＜0.01).GL01在肝癌中的表达与TNM分期相关(P＜0.05).单因素生存分析表明,GL01表达、淋巴结转移及TNM分期与患者的预后相关(P＜0.05).多因素生存分析表明,GLO1表达及TNM分期可作为肝癌患者预后评估的独立因素.结论 GL01与肝癌的发生、发展及预后密切相关.
목적 탐토을이철매1(GL01)재간암중적표체급기의의.방법 응용면역조직화학련매균항생물소단백-과양화물매(SP)법검측20례정상간조직급102례원발성간암조직중GL01적표체,탐토간암중GLOI표체여림상병리특정급예후적관계.결과 GL01재간암조직중적표체솔위76.5％,명현고우정상간조직(0％),차이유통계학의의(P＜0.01).GL01재간암중적표체여TNM분기상관(P＜0.05).단인소생존분석표명,GL01표체、림파결전이급TNM분기여환자적예후상관(P＜0.05).다인소생존분석표명,GLO1표체급TNM분기가작위간암환자예후평고적독립인소.결론 GL01여간암적발생、발전급예후밀절상관.
Objective To investigate the expression and prognostic significance of glyoxalase 1 (GLO1) in hepatocellular carcinoma (HCC).Methods Immunohistochemistry was applied to detect GLO1 expression in 20 normal liver tissues and 102 primary hepatocellular carcinoma tissues,and the relationship between GLO1 expression and clinicopathologic factors and prognosis was also evaluated in HCC tissues.Results The high-expression rate of GLO1 in HCC was 76.5％,significantly higher than that in normal tissues (0％) (P ＜ 0.01).GLO1 expression was closely associated with TNM stages (P ＜ 0.05).Univariate analysis revealed that GL01 expression,lymph node metastasis and TNM stage were related to the prognosis of patients with HCC (P ＜ 0.05).Multivariate survival analysis showed that GLOl expression and TNM stage could be used as independent prognostic factors in HCC.Conclusion GLO1 expression is strongly correlated with the formation,development and prognosis of HCC.