CAJ | 학술논문

目的探讨性激素失衡在男性肝移植患者术前评估中的临床意义.方法选取2011年6月至2013年6月原位同种异体肝移植男性患者71例作为观察对象,根据原发病分为两组:肝癌组35例,肝硬化失代偿组36例.另选取健康男性20例作为对照组.采用放射免疫法测定观察对象术前及对照组血清泌乳素、雌二醇、睾酮含量并计算雌二醇/睾酮比值(E2/T),采用单因素方差分析比较各组间差异.结果与对照组[(6.79 ±2.21) ng/μg]比较,在肝癌组[(16.99 ±6.64) ng/lμg]、肝硬化失代偿组[(13.93±3.31) ng/μg] E2/T水平升高,差异有统计学意义(P＜0.05),且在肝癌组升高更明显,差异有统计学意义(P＜0.05)；肝癌肝移植患者中,与甲胎蛋白(AFP)≥400 μg/L组[(13.89 ±3.37) ng/lμg]比较,E2/T在AFP＜ 400 μg/L组[(19.07±7.S0) ng/μg]有明显升高,差异有统计学意义(P＜0.05).结论 E2/T可作为肝移植患者术前评估的指标之一；对AFP＜ 400μg/L而临床不能明确原发性肝癌(HCC)患者,在肝癌的诊断方面具有参考价值.
목적 탐토성격소실형재남성간이식환자술전평고중적림상의의.방법 선취2011년6월지2013년6월원위동충이체간이식남성환자71례작위관찰대상,근거원발병분위량조:간암조35례,간경화실대상조36례.령선취건강남성20례작위대조조.채용방사면역법측정관찰대상술전급대조조혈청비유소、자이순、고동함량병계산자이순/고동비치(E2/T),채용단인소방차분석비교각조간차이.결과 여대조조[(6.79 ±2.21) ng/μg]비교,재간암조[(16.99 ±6.64) ng/lμg]、간경화실대상조[(13.93±3.31) ng/μg] E2/T수평승고,차이유통계학의의(P＜0.05),차재간암조승고경명현,차이유통계학의의(P＜0.05)；간암간이식환자중,여갑태단백(AFP)≥400 μg/L조[(13.89 ±3.37) ng/lμg]비교,E2/T재AFP＜ 400 μg/L조[(19.07±7.S0) ng/μg]유명현승고,차이유통계학의의(P＜0.05).결론 E2/T가작위간이식환자술전평고적지표지일；대AFP＜ 400μg/L이림상불능명학원발성간암(HCC)환자,재간암적진단방면구유삼고개치.
Objective To explore the clinical significance of sex hormones imbalance in preoperative evaluation before liver transplantation.Methods Seventy-one male patients who received liver transplantation from June 2011 to June 2013 in the first affiliated hospital of Zhengzhou University were selected as the observation group.They were divided into liver cancer group (35 cases) and cirrhosis decompensation group (36 cases) according to the original diseases.Furthermore,20 healthy male cases served as as the control group.Serum prolactin (PRL),estradiol (E2) and testosterone (T) were measured by using radioimmunoassay,and the ratio of E2 to T was also calculated.Results The E2/T ratio in liver cancer group [(16.99 ±6.64) ng/μg] and cirrhosis decompensation group [(13.93 ± 3.31) ng/μg] was significantly increased as compared with control group [(6.79 ±2.21) ng/μg,P ＜0.05],and this reduction seemd to be significant in HCC group than in cirrhosis decompensation group.As compared with AFP ≥ 400 μg/Lgroup [(13.89 ± 3.37)ng/ μg],the level of E2/T in AFP ＜ 400 μg/L group [(19.07 ± 7.50) ng/μg] was higher with the difference being statistically significant (P ＜ O.05).Conclusion E2/T ratio can be used as a preoperative indicator to patients before liver transplantation.Sex hormones have the reference value in the diagnosis of incidental hepatic cellular cancer,especially for the patients with low AFP.