中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
1期
187-189
,共3页
李宇%吴柳青%林峥%徐旭仲
李宇%吳柳青%林崢%徐旭仲
리우%오류청%림쟁%서욱중
右美托咪啶%芬太尼%麻醉%血液动力学
右美託咪啶%芬太尼%痳醉%血液動力學
우미탁미정%분태니%마취%혈액동역학
Dexmedetomidine%Fentanyl%Anesthesia%Hemodynamic
目的 观察右美托咪啶对麻醉诱导和气管插管时血液动力学的影响.方法 选取30例心血管疾病的患者分为两组:研究组患者给予右美托咪啶和芬太尼(效应部位浓度为2 μg/L)；对照组患者给予安慰剂和芬太尼(效应部位浓度为2 μg/L).应用靶控灌注系统给予异丙酚和芬太尼实施麻醉.记录患者心脏的收缩压(SBP)、舒张压(DBP)、心率(HR),并计算诱导期和插管期的参数变化.结果 诱导麻醉后,研究组患者的SBP[127 mmHg(1 mmHg =0.133 kPa)]较对照组患者的90 mmHg显著升高(P＜0.05).实施插管后,对照组患者的SBP达到了160 mmHg,而研究组患者的SBP没有明显变化.由气管插管造成的SBP显著增加占研究组病例的3％,远低于对照组(70％,P＜0.05).结论 右美托咪啶和芬太尼联用能抑制实施麻醉造成的血压降低以及减轻气管插管引起的心血管反应.
目的 觀察右美託咪啶對痳醉誘導和氣管插管時血液動力學的影響.方法 選取30例心血管疾病的患者分為兩組:研究組患者給予右美託咪啶和芬太尼(效應部位濃度為2 μg/L)；對照組患者給予安慰劑和芬太尼(效應部位濃度為2 μg/L).應用靶控灌註繫統給予異丙酚和芬太尼實施痳醉.記錄患者心髒的收縮壓(SBP)、舒張壓(DBP)、心率(HR),併計算誘導期和插管期的參數變化.結果 誘導痳醉後,研究組患者的SBP[127 mmHg(1 mmHg =0.133 kPa)]較對照組患者的90 mmHg顯著升高(P＜0.05).實施插管後,對照組患者的SBP達到瞭160 mmHg,而研究組患者的SBP沒有明顯變化.由氣管插管造成的SBP顯著增加佔研究組病例的3％,遠低于對照組(70％,P＜0.05).結論 右美託咪啶和芬太尼聯用能抑製實施痳醉造成的血壓降低以及減輕氣管插管引起的心血管反應.
목적 관찰우미탁미정대마취유도화기관삽관시혈액동역학적영향.방법 선취30례심혈관질병적환자분위량조:연구조환자급여우미탁미정화분태니(효응부위농도위2 μg/L)；대조조환자급여안위제화분태니(효응부위농도위2 μg/L).응용파공관주계통급여이병분화분태니실시마취.기록환자심장적수축압(SBP)、서장압(DBP)、심솔(HR),병계산유도기화삽관기적삼수변화.결과 유도마취후,연구조환자적SBP[127 mmHg(1 mmHg =0.133 kPa)]교대조조환자적90 mmHg현저승고(P＜0.05).실시삽관후,대조조환자적SBP체도료160 mmHg,이연구조환자적SBP몰유명현변화.유기관삽관조성적SBP현저증가점연구조병례적3％,원저우대조조(70％,P＜0.05).결론 우미탁미정화분태니련용능억제실시마취조성적혈압강저이급감경기관삽관인기적심혈관반응.
Objective To evaluate the effect of dexmedetomidine combined with fentanyl on hemodynamics.Methods Patients were assigned to two groups,research group (dexmedetomidine,effect-site concentration (ESC) of fentanyl is 2 μg/L) ; control group (placebo,ESC of fentanyl is 2 μg/L).Dexmedetomidine or placebo saline was administered 15 minutes before anesthetic induction.Anesthesia was induced with propofol and fentanyl using a target-controlled infusion system.Hemodynamic parameters:systolic (SBP) and diastolic blood pressures (DBP),and heart rate (HR) during anesthetic induction were measured and the percent changes were calculated for both induction and intubation.Results After inducing anesthesia,SBP was significantly higher in research group [127 mmHg(1 mmHg=0.133 kPa)] than control group (90 mmHg).The SBP in control group reached 160 mmHg after intubation,but no significantchange in SBP was noted in research group.The percent increase in SBP due to tracheal intubation in research group was 3％ and was significantly lower than that of control group (70％).Conclusion Dexmedetomidine combined with fentanyl during anesthetic induction suppresses the decrease in blood pressure due to anesthetic induction and also blunts the cardiovascular response to tracheal intubation.
