中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
2期
266-268
,共3页
微管不稳定蛋白%Endoglin%微血管密度%大肠癌
微管不穩定蛋白%Endoglin%微血管密度%大腸癌
미관불은정단백%Endoglin%미혈관밀도%대장암
Stathmin%Endoglin%Microvessel density%Colorectal carcinoma
目的 探讨微管不稳定蛋白(Stathmin)和Endoglin标记的微血管密度计数(MVD)在大肠癌中的表达及其与临床病理学参数之间的关系.方法 收集46例大肠癌患者手术切除的肿瘤组织和癌旁组织,运用免疫组织化学法检测Stathmin和Endoglin标记的MVD在组织中表达水平.结果 Stathmin大肠癌组织的表达率为69.57％ (32/46),明显高于癌旁组织表达率[34.78％ (16/46)],两者差异有统计学意义(P＜0.01),Stathmin表达水平与大肠癌组织学分化程度、浸润深度、TNM分期、淋巴结转移明显相关(P＜0.05);Endoglin标记的MVD大肠癌组织的表达强度为(68.27±5.66)个,明显高于癌旁组织的表达强度[(41.51±4.52)个],两者差异有统计学意义(P＜0.01);Endoglin标记的MVD表达强度与大肠癌浸润深度、TNM分期、淋巴结转移明显相关(P＜0.05).结论 联合检测Stathmin和Endoglin有助于判断大肠癌临床生物学行为.
目的 探討微管不穩定蛋白(Stathmin)和Endoglin標記的微血管密度計數(MVD)在大腸癌中的錶達及其與臨床病理學參數之間的關繫.方法 收集46例大腸癌患者手術切除的腫瘤組織和癌徬組織,運用免疫組織化學法檢測Stathmin和Endoglin標記的MVD在組織中錶達水平.結果 Stathmin大腸癌組織的錶達率為69.57％ (32/46),明顯高于癌徬組織錶達率[34.78％ (16/46)],兩者差異有統計學意義(P＜0.01),Stathmin錶達水平與大腸癌組織學分化程度、浸潤深度、TNM分期、淋巴結轉移明顯相關(P＜0.05);Endoglin標記的MVD大腸癌組織的錶達彊度為(68.27±5.66)箇,明顯高于癌徬組織的錶達彊度[(41.51±4.52)箇],兩者差異有統計學意義(P＜0.01);Endoglin標記的MVD錶達彊度與大腸癌浸潤深度、TNM分期、淋巴結轉移明顯相關(P＜0.05).結論 聯閤檢測Stathmin和Endoglin有助于判斷大腸癌臨床生物學行為.
목적 탐토미관불은정단백(Stathmin)화Endoglin표기적미혈관밀도계수(MVD)재대장암중적표체급기여림상병이학삼수지간적관계.방법 수집46례대장암환자수술절제적종류조직화암방조직,운용면역조직화학법검측Stathmin화Endoglin표기적MVD재조직중표체수평.결과 Stathmin대장암조직적표체솔위69.57％ (32/46),명현고우암방조직표체솔[34.78％ (16/46)],량자차이유통계학의의(P＜0.01),Stathmin표체수평여대장암조직학분화정도、침윤심도、TNM분기、림파결전이명현상관(P＜0.05);Endoglin표기적MVD대장암조직적표체강도위(68.27±5.66)개,명현고우암방조직적표체강도[(41.51±4.52)개],량자차이유통계학의의(P＜0.01);Endoglin표기적MVD표체강도여대장암침윤심도、TNM분기、림파결전이명현상관(P＜0.05).결론 연합검측Stathmin화Endoglin유조우판단대장암림상생물학행위.
Objective To analyze the relationship between the expression of Stathmin and endoglin-marked microvessel density (MVD) and clinicopathological features of colorectal carcinoma.Methods Immunohistochemistry was used to detect the expression levels of Stathmin and MVD marked with endoglin in 46 cases of human colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of Stathmin was 69.57％ (32/46) in colorectal carcinoma tissues,and 34.78％(16/46) in non-cancerous adjacent colorectal tissues (P ＜0.01).The expression of Stathmin was related to histologic grade,serosa invasion,TNM stage and lymph node metastasis in colorectal carcinoma (P ＜0.05).The expression of MVD marked with endoglin was (68.27 ± 5.66) in colorectal carcinoma tissues,and (41.51 ±4.52) in non-cancerous adjacent colorectal tissues (P ＜0.01).The expression of MVD was related to serosa invasion,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion The combined detection of Stathmin and endoglin may be used to determine the biological behaviors of colorectal carcinoma.
