中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
3期
636-638
,共3页
严峻%卢桂花%阮玉山%廖兴胜%罗昱%肖绍文
嚴峻%盧桂花%阮玉山%廖興勝%囉昱%肖紹文
엄준%로계화%원옥산%료흥성%라욱%초소문
脑胶质瘤%复发%预后
腦膠質瘤%複髮%預後
뇌효질류%복발%예후
Cerebral gliomas%Recurrent%Prognosis
目的 分析影响脑胶质瘤患者复发的因素.方法 采用聚合酶链反应(PCR)、免疫组织化学法分别检测肿瘤精子蛋白32前体(OY-TES-1) mRNA和蛋白表达.采用Cox比例风险回归模型分析影响胶质瘤复发的因素.结果 复发性脑胶质瘤OY-TES-1 mRNA阳性率为57.50％(46/80),OY-TES-1蛋白阳性表达率为33.75％ (27/80).多困素分析显示首次病理级别和OY-TES-1 mRNA表达水平是影响胶质瘤复发时间的独立预后因素.结论 检测OY-TES-1 mRNA有助于检测胶质瘤复发时间.
目的 分析影響腦膠質瘤患者複髮的因素.方法 採用聚閤酶鏈反應(PCR)、免疫組織化學法分彆檢測腫瘤精子蛋白32前體(OY-TES-1) mRNA和蛋白錶達.採用Cox比例風險迴歸模型分析影響膠質瘤複髮的因素.結果 複髮性腦膠質瘤OY-TES-1 mRNA暘性率為57.50％(46/80),OY-TES-1蛋白暘性錶達率為33.75％ (27/80).多睏素分析顯示首次病理級彆和OY-TES-1 mRNA錶達水平是影響膠質瘤複髮時間的獨立預後因素.結論 檢測OY-TES-1 mRNA有助于檢測膠質瘤複髮時間.
목적 분석영향뇌효질류환자복발적인소.방법 채용취합매련반응(PCR)、면역조직화학법분별검측종류정자단백32전체(OY-TES-1) mRNA화단백표체.채용Cox비례풍험회귀모형분석영향효질류복발적인소.결과 복발성뇌효질류OY-TES-1 mRNA양성솔위57.50％(46/80),OY-TES-1단백양성표체솔위33.75％ (27/80).다곤소분석현시수차병리급별화OY-TES-1 mRNA표체수평시영향효질류복발시간적독립예후인소.결론 검측OY-TES-1 mRNA유조우검측효질류복발시간.
Objective To analyze the recurrent factors of patients with glioma.Methods The expression of sperm protein 32 precursor (OY-TES-1) mRNA and protein was detected by using PCR and immunohistochemistry respectively.The Cox regression model was used to analyze the recurrent factors of patients with glioma.Results The positive rate of OY-TES-1 mRNA and protein was 57.50％ (46/80) and 33.75％ (27/80) respectively in 80 cases of recurrent glioma.Multivariate survival analysis showed that the histologic grade of the first time and the the expression of OY-TES-1 mRNA were independent and statistically significant prognostic factors for the recurrent time of the glioma.Conclusion OY-TES-1 mRNA could be used as the prognostic indicators of the recurrent time for glioma.
