CAJ | 학술논문

目的探讨高迁移率族蛋白A1(HMGAl)表达与胸中段食管鳞癌患者预后的关系.方法收集手术治疗189例胸中段食管癌患者临床资料,采用免疫组织化学法进行HMGA1检测,采用Kaplan-meier法进行生存分析、用Cox回归分析判定独立预后因素.结果 T1、T2和T3患者HMGA1表达率分别为54.5％、61.4％和78.5％(P＜0.05);有、无淋巴结转移患者HMGA1表达率分别为82.7％和63.9％ (P＜0.01).T2患者中,有、无HMGA1蛋白表达者5年生存率分别为.34.3％和68.2％ (P ＜0.05);T3患者中,有、无HMGA1蛋白表达组的5年生存率分别为25.3％和54.5％ (P＜0.05).无淋巴结转移(pN0)患者中,有、无HMGA1蛋白表达患者5年生存率分别为42.0％和66.7％ (P ＜0.05);有淋巴结转移(pNl)患者中,有、无HMGA1蛋白表达患者5年生存率分别为14.9％和50.0％ (P＜0.05).结论食管鳞癌不同的T、N分期中HMGA1蛋白表达存在差异;HMGA1蛋白过度表达者5年生存率降低;肿瘤浸润、淋巴结转移和HMGA1蛋白过度表达是独立的不利预后因素.
목적 탐토고천이솔족단백A1(HMGAl)표체여흉중단식관린암환자예후적관계.방법 수집수술치료189례흉중단식관암환자림상자료,채용면역조직화학법진행HMGA1검측,채용Kaplan-meier법진행생존분석、용Cox회귀분석판정독립예후인소.결과 T1、T2화T3환자HMGA1표체솔분별위54.5％、61.4％화78.5％(P＜0.05);유、무림파결전이환자HMGA1표체솔분별위82.7％화63.9％ (P＜0.01).T2환자중,유、무HMGA1단백표체자5년생존솔분별위.34.3％화68.2％ (P ＜0.05);T3환자중,유、무HMGA1단백표체조적5년생존솔분별위25.3％화54.5％ (P＜0.05).무림파결전이(pN0)환자중,유、무HMGA1단백표체환자5년생존솔분별위42.0％화66.7％ (P ＜0.05);유림파결전이(pNl)환자중,유、무HMGA1단백표체환자5년생존솔분별위14.9％화50.0％ (P＜0.05).결론 식관린암불동적T、N분기중HMGA1단백표체존재차이;HMGA1단백과도표체자5년생존솔강저;종류침윤、림파결전이화HMGA1단백과도표체시독립적불리예후인소.
Objective To investigate the expression of high mobility group A1 (HMGA1) protein and its relationship to the prognosis of esophageal cancer after esophagectomy.Methods One hundred and eighty-nine patients with squamous cell carcinoma at the middle-third of the esophagus were enrolled in this study.The expression of HMGA1 protein was detected by using immunohistochemistry.According to the clinicopathologic factors,the difference of HMGA1 protein expression was compared by x2 test.Kaplanmeier method was performed to calculate the survival rate.Cox regression multivariate analysis was performed to determine independent prognostic factors.Results The HMGA1 protein expression rate in T1 stage,T2 stage and T3 stage was separately 54.5％,61.4％ and 78.5％ (P ＜ 0.05).The positive expression rate of HMGA1 protein in patients with lymph node metastasis was significantly higher than in those without metastasis (P ＜ 0.01).The 5-year survival rate in patients positive for the expression of HMGA1 protein was significantly lower than in those negative for the expression of HMGA1 protein (P ＜0.01),that in T2 and T3 stage patients positive for the expression of HMGA1 protein was significantly lower than in those negative for the HMGA1 protein expression (P ＜ 0.05),that in N0 stage patients positive for the HMGA1 protein expression was significantly lower than in negative for the HMGA1 protein expression (P ＜ 0.05),and that in N1 stage patients positive for the HMGA1 protein expression was significantly lower than in those negative for the HMGA1 protein expression (P ＜ 0.05).The result of Cox analysis demonstrated that T stage,N stage and HMGA1 protein positive expression were independent prognostic factors.Conclusion HMGA1 protein overexpression was detected in esophageal squamous cell carcinoma and was found to be significantly associated with T stage and lymph node metastasis.The 5-year survival rate in the patients with HMGA1 protein overexpression was significantly lower than in those negative for the HMGA1 protein expression.Lymphnode metastasis and HMGA1 protein overexpression were independent prognostic factors.