中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
6期
1286-1288
,共3页
陈尼卡%李训军%向建波%郎莹%刘雅贞%蒋晓江
陳尼卡%李訓軍%嚮建波%郎瑩%劉雅貞%蔣曉江
진니잡%리훈군%향건파%랑형%류아정%장효강
脑缺血%自体血栓%明胶海绵%模型,动物
腦缺血%自體血栓%明膠海綿%模型,動物
뇌결혈%자체혈전%명효해면%모형,동물
Cerebral ischemia%Autologous blood clots%Gelatin sponge%Models,animal
目的 制作自体血栓、明胶海绵两种不同材料及不同大小的栓子,以血管介入技术栓塞犬大脑中动脉方法观察犬局部脑栓塞模型效果.方法 选取30条中华田园犬,随机分成自体血栓组、明胶海绵A组及明胶海绵B组,分别以直径1.1～1.3mm自体血栓条、直径3.0mm明胶海绵颗粒、直径1.0～1.5 mm明胶海绵微粒作为栓子自导管注入颈内动脉,随后行数字减影血管造影、核磁共振、神经功能评分来评价效果.结果 对比大脑中动脉闭塞成功率(明胶海绵A组90％、B组20％、自体血栓组70％),明胶海绵A组、自体血栓组与B组比较差异均有统计学意义(P＜0.05),而明胶海绵A组与自体血栓组比较差异无统计学意义(P＞0.05);明胶海绵A组头颅核磁阳性率为80％、B组为30％、自体血栓组为50％,明胶海绵A组与B组比较差异有统计学意义(P＜0.05),而自体血栓组与A组、B组比较差异均无统计学意义(P＞0.05);明胶海绵A组及自体血栓组神经功能评分均多位于6～7分值段,而B组多位于10～11分值段,明胶海绵A组、自体血栓组与明胶海绵B组比较差异均有统计学意义(P＜0.05),明胶海绵A组与自体血栓组比较差异无统计学意义(P＞0.05).结论 使用明胶海绵A组建立犬局部脑缺血模型较自体血栓而言具有制作简便、闭塞准确率高、模型稳定的特点.明胶海绵微粒B组在成功率、效果及模型后续观察上均不及前两者.
目的 製作自體血栓、明膠海綿兩種不同材料及不同大小的栓子,以血管介入技術栓塞犬大腦中動脈方法觀察犬跼部腦栓塞模型效果.方法 選取30條中華田園犬,隨機分成自體血栓組、明膠海綿A組及明膠海綿B組,分彆以直徑1.1～1.3mm自體血栓條、直徑3.0mm明膠海綿顆粒、直徑1.0～1.5 mm明膠海綿微粒作為栓子自導管註入頸內動脈,隨後行數字減影血管造影、覈磁共振、神經功能評分來評價效果.結果 對比大腦中動脈閉塞成功率(明膠海綿A組90％、B組20％、自體血栓組70％),明膠海綿A組、自體血栓組與B組比較差異均有統計學意義(P＜0.05),而明膠海綿A組與自體血栓組比較差異無統計學意義(P＞0.05);明膠海綿A組頭顱覈磁暘性率為80％、B組為30％、自體血栓組為50％,明膠海綿A組與B組比較差異有統計學意義(P＜0.05),而自體血栓組與A組、B組比較差異均無統計學意義(P＞0.05);明膠海綿A組及自體血栓組神經功能評分均多位于6～7分值段,而B組多位于10～11分值段,明膠海綿A組、自體血栓組與明膠海綿B組比較差異均有統計學意義(P＜0.05),明膠海綿A組與自體血栓組比較差異無統計學意義(P＞0.05).結論 使用明膠海綿A組建立犬跼部腦缺血模型較自體血栓而言具有製作簡便、閉塞準確率高、模型穩定的特點.明膠海綿微粒B組在成功率、效果及模型後續觀察上均不及前兩者.
목적 제작자체혈전、명효해면량충불동재료급불동대소적전자,이혈관개입기술전새견대뇌중동맥방법관찰견국부뇌전새모형효과.방법 선취30조중화전완견,수궤분성자체혈전조、명효해면A조급명효해면B조,분별이직경1.1～1.3mm자체혈전조、직경3.0mm명효해면과립、직경1.0～1.5 mm명효해면미립작위전자자도관주입경내동맥,수후행수자감영혈관조영、핵자공진、신경공능평분래평개효과.결과 대비대뇌중동맥폐새성공솔(명효해면A조90％、B조20％、자체혈전조70％),명효해면A조、자체혈전조여B조비교차이균유통계학의의(P＜0.05),이명효해면A조여자체혈전조비교차이무통계학의의(P＞0.05);명효해면A조두로핵자양성솔위80％、B조위30％、자체혈전조위50％,명효해면A조여B조비교차이유통계학의의(P＜0.05),이자체혈전조여A조、B조비교차이균무통계학의의(P＞0.05);명효해면A조급자체혈전조신경공능평분균다위우6～7분치단,이B조다위우10～11분치단,명효해면A조、자체혈전조여명효해면B조비교차이균유통계학의의(P＜0.05),명효해면A조여자체혈전조비교차이무통계학의의(P＞0.05).결론 사용명효해면A조건립견국부뇌결혈모형교자체혈전이언구유제작간편、폐새준학솔고、모형은정적특점.명효해면미립B조재성공솔、효과급모형후속관찰상균불급전량자.
Objective Through the blood vessels in the brain artery embolization method to observe the effect of local cerebral embolism model for cerebrovascular disease research to provide a reference.Emboli used in the experiments are autologous blood clot and two different sizes of gelatin sponges.Methods 30 adult dogs were randomly divided into groups (n =10) of autologous blood clots,gelatin sponge group A and B.Emboli used in every group were homemade thrombosis (diameter of about 1.1-1.3 mm) and two sizes of homemade gelatin sponge particles which diameter is about 3.0 mm and 1.0-1.5 mm.Emboli are injected into the internal carotid artery intervention through the catheter,and then to digital subtraction angiography,magnetic resonance imagery,neurological score to evaluate the results.Results Compared the success rate of middle cerebral artery occlusion which group A is 90％,group B is 20％ and the autologous blood clots group is 70％,no significant difference between gToup A and the autologous blood clots group (P ＞ 0.05),while group B is differ from them (P ＜ 0.05).Contrast the positive rate of cranial Magnetic Resonance Imagery which A group is 80％,group B is 30％ and the autologous blood clots group is 50％,there is statistically significant differences between group A and group B (P ＜ 0.05),and the autologous blood clots group,group A and group B were not statistically different (P ＞ 0.05) ; In comparing the neurological score,no significant difference showed between A group and the autologous blood clots group (P ＞ 0.05),but there are significant differences between the two groups which scored 6-7 points each and group B which scored 10-11 points (P ＜0.05).Conclusion In the model making,gelatin sponge group A which has advantages on simple,stable is better than group autologous blood.In terms of success rate,effects and follow-up observations on the model,group B was significantly less than the first two.
