中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
6期
1312-1313
,共2页
乳腺癌%细丝蛋白A%热休克蛋白90
乳腺癌%細絲蛋白A%熱休剋蛋白90
유선암%세사단백A%열휴극단백90
Breast carcinoma%Filam in A%Heat shock protein 90
目的 探讨细丝蛋白A(FLNa)和热休克蛋白90(HSP90)在乳腺癌组织中的表达及其与乳腺癌临床生物学行为的关系.方法 应用免疫组织化学法检测69例乳腺癌组织和癌旁组织中FLNa和HSP90的表达水平.结果 FLNa在乳腺癌组织中表达率为68.12％,在癌旁组织中表达率为10.14％,两者差异有统计学意义(P＜0.01),FLNa表达水平与乳腺癌组织学分级、TNM分期、淋巴结转移明显相关(P＜0.05);HSP90在乳腺癌组织中表达率为44.93％,在癌旁组织中表达率为8.70％,两者差异有统计学意义(P＜0.01),HSP90表达水平与乳腺癌肿瘤大小、组织学分化程度、TNM分期、淋巴结转移等明显相关(P＜0.05).结论 同时检测FLNa和HSP90有助于评估乳腺癌的恶性程度、判断其转移潜能.
目的 探討細絲蛋白A(FLNa)和熱休剋蛋白90(HSP90)在乳腺癌組織中的錶達及其與乳腺癌臨床生物學行為的關繫.方法 應用免疫組織化學法檢測69例乳腺癌組織和癌徬組織中FLNa和HSP90的錶達水平.結果 FLNa在乳腺癌組織中錶達率為68.12％,在癌徬組織中錶達率為10.14％,兩者差異有統計學意義(P＜0.01),FLNa錶達水平與乳腺癌組織學分級、TNM分期、淋巴結轉移明顯相關(P＜0.05);HSP90在乳腺癌組織中錶達率為44.93％,在癌徬組織中錶達率為8.70％,兩者差異有統計學意義(P＜0.01),HSP90錶達水平與乳腺癌腫瘤大小、組織學分化程度、TNM分期、淋巴結轉移等明顯相關(P＜0.05).結論 同時檢測FLNa和HSP90有助于評估乳腺癌的噁性程度、判斷其轉移潛能.
목적 탐토세사단백A(FLNa)화열휴극단백90(HSP90)재유선암조직중적표체급기여유선암림상생물학행위적관계.방법 응용면역조직화학법검측69례유선암조직화암방조직중FLNa화HSP90적표체수평.결과 FLNa재유선암조직중표체솔위68.12％,재암방조직중표체솔위10.14％,량자차이유통계학의의(P＜0.01),FLNa표체수평여유선암조직학분급、TNM분기、림파결전이명현상관(P＜0.05);HSP90재유선암조직중표체솔위44.93％,재암방조직중표체솔위8.70％,량자차이유통계학의의(P＜0.01),HSP90표체수평여유선암종류대소、조직학분화정도、TNM분기、림파결전이등명현상관(P＜0.05).결론 동시검측FLNa화HSP90유조우평고유선암적악성정도、판단기전이잠능.
Objective To explore the expression of filam in A (FLNa) and heat shock protein 90 (HSP90) and the clinical biological behavior of breast carcinoma.Methods FLNa and HSP90 expression in 69 cases of human breast carcinoma tissues and non-cancerous adjacent breast tissues(5 cm distance away from the margin of breast carcinoma) were examined by using immunohistochemical method.Results The expression rate of FLNa was 68.12％ in breast carcinoma tissues,and 10.14％ in non-cancerous adjacent breast tissues (P ＜ 0.01),the expressions of FLNa were related breast carcinoma to histology grade,TNM stage and lymph node metastasis (P ＜ 0.05) ; the expression rate of HSP90 was 44.93％ in breast carcinoma tissues,and 8.70％ in non-cancerous adjacent breast tissues (P ＜0.01).there was a close relation between the expression of HSP90 and tumor size,histology grade,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion Detecting the expressive levels of FLNa and HSP90 simultaneously might be helpful for evaluating the malignance and predicting the metastatic potential of breast carcinoma.
