中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
9期
2029-2031
,共3页
苏琳%吕春龙%高品%纪奕顺%郑淑龙%高军
囌琳%呂春龍%高品%紀奕順%鄭淑龍%高軍
소림%려춘룡%고품%기혁순%정숙룡%고군
肝转移%结直肠癌%β1整合素
肝轉移%結直腸癌%β1整閤素
간전이%결직장암%β1정합소
Liver metastasis%Colorectal cancer%β1 integrin
目的 观察结直肠癌肝转移中β1整合素表达与临床病理特征的关系,探讨β1整合素在结直肠癌肝转移中的意义.方法 收集41例未行新辅助化疗的结直肠癌肝转移手术切除标本及其临床病理资料.采用苏木素-伊红(HE)染色检测结直肠癌肝转移标本中β1整合素的表达,分析结直肠癌肝转移中β1整合素表达与临床病理特征的关系.结果 41例中有29例(70.7％)肝转移癌β1整合素表达阳性.29例中28例(96.6％)有脉管侵犯,明显多于无脉管侵犯者(1例,3.4％);26例(89.7％)有淋巴结转移,明显多于无淋巴转移者(3例,10.3％);Ⅲ期(9例)+Ⅳ期(16例)共25例(86.2％),明显多于Ⅰ期(0例)+Ⅱ期(4例)共4例(13.8％);中分化18例(62.1％)+低分化11例(37.9％),明显多于高分化者(0例),差异均有统计学意义(P＜0.05).结论 结直肠癌肝转移中β1整合素表达与原发癌临床病理特征有相关,β1整合素在结直肠癌肝转移的发生发展中起重要作用.
目的 觀察結直腸癌肝轉移中β1整閤素錶達與臨床病理特徵的關繫,探討β1整閤素在結直腸癌肝轉移中的意義.方法 收集41例未行新輔助化療的結直腸癌肝轉移手術切除標本及其臨床病理資料.採用囌木素-伊紅(HE)染色檢測結直腸癌肝轉移標本中β1整閤素的錶達,分析結直腸癌肝轉移中β1整閤素錶達與臨床病理特徵的關繫.結果 41例中有29例(70.7％)肝轉移癌β1整閤素錶達暘性.29例中28例(96.6％)有脈管侵犯,明顯多于無脈管侵犯者(1例,3.4％);26例(89.7％)有淋巴結轉移,明顯多于無淋巴轉移者(3例,10.3％);Ⅲ期(9例)+Ⅳ期(16例)共25例(86.2％),明顯多于Ⅰ期(0例)+Ⅱ期(4例)共4例(13.8％);中分化18例(62.1％)+低分化11例(37.9％),明顯多于高分化者(0例),差異均有統計學意義(P＜0.05).結論 結直腸癌肝轉移中β1整閤素錶達與原髮癌臨床病理特徵有相關,β1整閤素在結直腸癌肝轉移的髮生髮展中起重要作用.
목적 관찰결직장암간전이중β1정합소표체여림상병리특정적관계,탐토β1정합소재결직장암간전이중적의의.방법 수집41례미행신보조화료적결직장암간전이수술절제표본급기림상병리자료.채용소목소-이홍(HE)염색검측결직장암간전이표본중β1정합소적표체,분석결직장암간전이중β1정합소표체여림상병리특정적관계.결과 41례중유29례(70.7％)간전이암β1정합소표체양성.29례중28례(96.6％)유맥관침범,명현다우무맥관침범자(1례,3.4％);26례(89.7％)유림파결전이,명현다우무림파전이자(3례,10.3％);Ⅲ기(9례)+Ⅳ기(16례)공25례(86.2％),명현다우Ⅰ기(0례)+Ⅱ기(4례)공4례(13.8％);중분화18례(62.1％)+저분화11례(37.9％),명현다우고분화자(0례),차이균유통계학의의(P＜0.05).결론 결직장암간전이중β1정합소표체여원발암림상병리특정유상관,β1정합소재결직장암간전이적발생발전중기중요작용.
Objective To discuss the significance of β1 integrin expression in hepatic metastasis of colorectal cancer by observing the correlation between β1 integrin expression in colorectal liver metastasis and clinicopathological characteristics.Methods Forty-one hepatectomy specimens of liver metastasis from colorectal cancer without neoadjuvant therapy were chosen for detection of the expression of β1 integrin by the hematoxylin and eosin (HE) immunohistochemical techniques.The clinicopathological characteristics of 41 cases were analyzed.Results There were 29 specimens (70.7％) positive for expression of β1 integrin in 41 cases.In the 29 cases,there were 28 (96.6％) cases of vascular invasion in primary colorectal cancer,26 (89.7％) case of lymphatic metastasis,25 (86.2％) cases of later TNM stages (9 cases of stage Ⅲ,and 16 cases of stage Ⅳ),18 (62.1％) cases of moderate differentiation and 11 (37.9％) cases of poor differentiation.There were statistically significant differences (P ＜ 0.05).Conclusion The expression of β1 integrin in colorectal liver metastasis may be closely associated with the clinicopathological features,suggesting that β1 integrin may play a role in hepatic metastasis from colorectal cancer.
