CAJ | 학술논문

目的探讨高尔基体糖蛋白73(GP73)和CD133与结直肠癌临床生物学行为的关系.方法收集82例结直肠癌患者手术切除的肿瘤组织及相应癌旁组织,采用免疫组织化学法检测GP73和CD133在组织中表达水平.结果 GP73在结直肠癌组织中表达率明显高于癌旁组织(84.15％比64.63％,P＜0.01),GP73表达水平与结直肠癌组织学分化程度、浸润深度明显相关(P＜0.05);CD133在结直肠癌组织中表达率明显高于癌旁组织(47.56％比15.85％,P＜0.01),CD133表达水平与结直肠癌TNM分期、淋巴结转移明显相关(P＜0.05).结论同时检测GP73和CD133的表达有助于判断结直肠癌患者的临床病理特征.
목적 탐토고이기체당단백73(GP73)화CD133여결직장암림상생물학행위적관계.방법 수집82례결직장암환자수술절제적종류조직급상응암방조직,채용면역조직화학법검측GP73화CD133재조직중표체수평.결과 GP73재결직장암조직중표체솔명현고우암방조직(84.15％비64.63％,P＜0.01),GP73표체수평여결직장암조직학분화정도、침윤심도명현상관(P＜0.05);CD133재결직장암조직중표체솔명현고우암방조직(47.56％비15.85％,P＜0.01),CD133표체수평여결직장암TNM분기、림파결전이명현상관(P＜0.05).결론 동시검측GP73화CD133적표체유조우판단결직장암환자적림상병리특정.
Objective To analyze the relationship between the expression of Golgi protein-73 (GP73) and CD133 with clinical biological behaviors of colorectal carcinoma.Methods Immunohisto-chemical method was used to assess the expression of GP73 and CD133 in 82 cases of colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of GP73 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (84.15％ vs.64.63％,P ＜0.01).The expression level of GP73 was related to histology grade and serosa invasion of colorectal carcinoma (P ＜ 0.05).Tthe expression rate of CD133 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (47.56％ vs.15.85％,P ＜0.01),and the expression of CD133 was closely related with TNM stage and lymph node metastasis of colorectal carcinoma (P ＜0.05).Conclusion GP73 and CD133 in colorectal carcinoma tissues might be used as markers for assessing the clinicopathological features.