中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
9期
2034-2035,封4
,共3页
分泌性白细胞蛋白酶抑制因子%结肠癌
分泌性白細胞蛋白酶抑製因子%結腸癌
분비성백세포단백매억제인자%결장암
Secretory leukocyte protease inhibitor%Colon cancer
目的 观察分泌性白细胞蛋白酶抑制因子(SLPI)在结肠癌中表达.方法 纳入在我院行手术切除的结肠癌组织与癌旁正常组织标本107例,组织芯片中SLPI蛋白的表达采用免疫组织化学法进行检测,并分析结直肠癌组织中SLPI表达与临床病理特征的关系.结果 SLPI表达与性别及年龄无相关(P＞0.05);而SLPI表达水平与癌组织分化程度、有无淋巴结转移、TNM分期有相关(P＜0.05);SLPI在结肠癌中呈阳性表达,而在癌旁正常黏膜组织中呈阴性表达,且主要定位于细胞质.结论 SLPI表达与年龄、性别无明显相关,而与分化程度、TNM分期、淋巴结转移明显相关.
目的 觀察分泌性白細胞蛋白酶抑製因子(SLPI)在結腸癌中錶達.方法 納入在我院行手術切除的結腸癌組織與癌徬正常組織標本107例,組織芯片中SLPI蛋白的錶達採用免疫組織化學法進行檢測,併分析結直腸癌組織中SLPI錶達與臨床病理特徵的關繫.結果 SLPI錶達與性彆及年齡無相關(P＞0.05);而SLPI錶達水平與癌組織分化程度、有無淋巴結轉移、TNM分期有相關(P＜0.05);SLPI在結腸癌中呈暘性錶達,而在癌徬正常黏膜組織中呈陰性錶達,且主要定位于細胞質.結論 SLPI錶達與年齡、性彆無明顯相關,而與分化程度、TNM分期、淋巴結轉移明顯相關.
목적 관찰분비성백세포단백매억제인자(SLPI)재결장암중표체.방법 납입재아원행수술절제적결장암조직여암방정상조직표본107례,조직심편중SLPI단백적표체채용면역조직화학법진행검측,병분석결직장암조직중SLPI표체여림상병리특정적관계.결과 SLPI표체여성별급년령무상관(P＞0.05);이SLPI표체수평여암조직분화정도、유무림파결전이、TNM분기유상관(P＜0.05);SLPI재결장암중정양성표체,이재암방정상점막조직중정음성표체,차주요정위우세포질.결론 SLPI표체여년령、성별무명현상관,이여분화정도、TNM분기、림파결전이명현상관.
Objective To investigate the secretory leukocyte protease inhibitor (SLPI) expression in colon cancer.Methods Inclusion in our hospital surgical resection of colon cancer tissue and adjacent normal tissue samples 107 cases,tissue microarray applications SLPI protein expression were detected by immunohistochemistry,SLPI expression analysis of colorectal cancer tissues with associated clinical and pathological features sex.Results SLPI expression and gender and age difference was not statistically significant (P ＞ 0.05) ; while SLPI expression levels in well with the low degree of lymph node metastasis,TNM staging difference was statistically significant (P ＜ 0.05) ; SLPI positive product positive expression in colon cancer,and in the adjacent normal mucosa cancer was negative,and is mainly localized in the cytoplasm.Conclusion SLPI expression with age,sex has nothing to do with the degree of differentiation,TNM stage,lymph node metastasis,and can be used as the main indicator to determine the prognosis of colon cancer has important clinical value.
