CAJ | 학술논문

目的探讨转录因子Sp1在肾盂尿路上皮细胞癌(肾盂癌)的表达及其临床意义.方法采用免疫组织化学PV-9000法检测Sp1蛋白在43例肾盂癌标本和11例肾盂正常黏膜组织的表达水平.结果 Sp1蛋白在肾盂癌和黏膜组织中的阳性表达率分别为74.4％(32/43)和0,组间差异有统计学意义(P＜0.05).Sp1在低分级和高分级肾盂癌组织中的阳性表达率分别为59.1％(13/22)和90.5％(19/21),Sp1在浅表性(Tis～T1)和浸润性(T2～T4)肾盂癌组织中的阳性表达率分别为58.3％(14/24)和94.7％(18/19),组间差异有统计学意义(P＜0.05).结论转录因子Sp1蛋白在肾盂癌组织中呈高表达,且其阳性表达与肿瘤的组织学分级和T分期呈正相关,提示Sp1参与了肾盂癌的发生和进展过程.
목적 탐토전록인자Sp1재신우뇨로상피세포암(신우암)적표체급기림상의의.방법 채용면역조직화학PV-9000법검측Sp1단백재43례신우암표본화11례신우정상점막조직적표체수평.결과 Sp1단백재신우암화점막조직중적양성표체솔분별위74.4％(32/43)화0,조간차이유통계학의의(P＜0.05).Sp1재저분급화고분급신우암조직중적양성표체솔분별위59.1％(13/22)화90.5％(19/21),Sp1재천표성(Tis～T1)화침윤성(T2～T4)신우암조직중적양성표체솔분별위58.3％(14/24)화94.7％(18/19),조간차이유통계학의의(P＜0.05).결론 전록인자Sp1단백재신우암조직중정고표체,차기양성표체여종류적조직학분급화T분기정정상관,제시Sp1삼여료신우암적발생화진전과정.
Objective To investigate the expression and clinical significance of transcription factor Sp1 in uroepithelial cell carcinoma (UCC) of renal pelvis.Methods The immunohistochemical PV-9000 method was used to study the expression level of Sp1 protein in 43 cases of UCC and 11 cases of normal mucosa in renal pelvis.Results The positive expression rate of Sp1 protein in UCC and normal mucosa of renal pelvis was 74.4％ and 0 (P ＜ 0.05),and that in low-grade and high-grade UCC of renal pelvis was 59.1％ and 90.5％ (P ＜ 0.05),that in superficial and infiltrated UCC of renal pelvis was 58.3％ and 94.7％ (P ＜ 0.05),respectively.Conclusion The positive expression of Sp1 protein is directly related to the histological grades and T stages of UCC in renal pelvis,suggesting Sp1 may participate in the carcinogenesis and progression of UCC.