中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
10期
2214-2216
,共3页
谭焱%朱水波%张晓明%顾明明%殷桂林
譚焱%硃水波%張曉明%顧明明%慇桂林
담염%주수파%장효명%고명명%은계림
肺栓塞%内皮素受体拮抗剂%溶栓%肌钙蛋白T%心肌缺血
肺栓塞%內皮素受體拮抗劑%溶栓%肌鈣蛋白T%心肌缺血
폐전새%내피소수체길항제%용전%기개단백T%심기결혈
Pulmonary embolism%Endothelin receptor antagonist%Thrombolysis%Troponin T%Myocardial ischemia
目的 观察尿激酶联合应用选择性内皮素-1受体拮抗剂BQ-123对急性肺栓塞继发心肌缺血损伤的保护作用.方法 20条Beagle犬随机分为5组:假手术组(Sham组)、肺栓塞组(PE组)、尿激酶溶栓组(UK组)、BQ-123组(BQ组)、尿激酶±BQ-123联合组(UK± BQ组),每组4条.测量各组栓塞前、栓塞后或溶栓后2.0、4.0、6.0h肺动脉平均压(mPAP)、冠状动脉血流量以及栓塞后6h血清肌钙蛋白T(cTnT)含量.结果 (1)肺栓塞0.5h后mPAP显著升高,接受尿激酶、BQ-123治疗后UK组与UK± BQ组mPAP下降,栓塞后4h分别为(26.67 ±2.08)、(20.00±2.00) mmHg(1 mmHg=0133 kPa),显著低于PE组[(37.33 ±4.16) mmHg,P＜0.05];(2)栓塞后6h,UK± BQ组血清cTnT值(611.93 ±97.50) ng/L小于UK组(747.22±62.72) ng/L和PE组[(900.79 ±71.11) ng/L,P＜0.05];(3)冠状动脉血流量显示:PE组下降,UK、BQ、UK+ BQ组不同程度增加,其中UK+ BQ组增加更明显(P＜0.05).结论 在溶栓治疗基础上联合应用内皮素-1受体拮抗剂BQ-123能显著降低肺动脉压力、增加冠状动脉血流量,极大程度上缓解急性肺栓塞继发急性心肌缺血损伤.
目的 觀察尿激酶聯閤應用選擇性內皮素-1受體拮抗劑BQ-123對急性肺栓塞繼髮心肌缺血損傷的保護作用.方法 20條Beagle犬隨機分為5組:假手術組(Sham組)、肺栓塞組(PE組)、尿激酶溶栓組(UK組)、BQ-123組(BQ組)、尿激酶±BQ-123聯閤組(UK± BQ組),每組4條.測量各組栓塞前、栓塞後或溶栓後2.0、4.0、6.0h肺動脈平均壓(mPAP)、冠狀動脈血流量以及栓塞後6h血清肌鈣蛋白T(cTnT)含量.結果 (1)肺栓塞0.5h後mPAP顯著升高,接受尿激酶、BQ-123治療後UK組與UK± BQ組mPAP下降,栓塞後4h分彆為(26.67 ±2.08)、(20.00±2.00) mmHg(1 mmHg=0133 kPa),顯著低于PE組[(37.33 ±4.16) mmHg,P＜0.05];(2)栓塞後6h,UK± BQ組血清cTnT值(611.93 ±97.50) ng/L小于UK組(747.22±62.72) ng/L和PE組[(900.79 ±71.11) ng/L,P＜0.05];(3)冠狀動脈血流量顯示:PE組下降,UK、BQ、UK+ BQ組不同程度增加,其中UK+ BQ組增加更明顯(P＜0.05).結論 在溶栓治療基礎上聯閤應用內皮素-1受體拮抗劑BQ-123能顯著降低肺動脈壓力、增加冠狀動脈血流量,極大程度上緩解急性肺栓塞繼髮急性心肌缺血損傷.
목적 관찰뇨격매연합응용선택성내피소-1수체길항제BQ-123대급성폐전새계발심기결혈손상적보호작용.방법 20조Beagle견수궤분위5조:가수술조(Sham조)、폐전새조(PE조)、뇨격매용전조(UK조)、BQ-123조(BQ조)、뇨격매±BQ-123연합조(UK± BQ조),매조4조.측량각조전새전、전새후혹용전후2.0、4.0、6.0h폐동맥평균압(mPAP)、관상동맥혈류량이급전새후6h혈청기개단백T(cTnT)함량.결과 (1)폐전새0.5h후mPAP현저승고,접수뇨격매、BQ-123치료후UK조여UK± BQ조mPAP하강,전새후4h분별위(26.67 ±2.08)、(20.00±2.00) mmHg(1 mmHg=0133 kPa),현저저우PE조[(37.33 ±4.16) mmHg,P＜0.05];(2)전새후6h,UK± BQ조혈청cTnT치(611.93 ±97.50) ng/L소우UK조(747.22±62.72) ng/L화PE조[(900.79 ±71.11) ng/L,P＜0.05];(3)관상동맥혈류량현시:PE조하강,UK、BQ、UK+ BQ조불동정도증가,기중UK+ BQ조증가경명현(P＜0.05).결론 재용전치료기출상연합응용내피소-1수체길항제BQ-123능현저강저폐동맥압력、증가관상동맥혈류량,겁대정도상완해급성폐전새계발급성심기결혈손상.
Objective To observe the effect of the selective endothelin receptor antagonist BQ-123 combined with urokinase against myocardial injury due to acute pulmonary embolism (APE).Methods Twenty healthy adult Beagle dogs were used,and randomly assigned to five groups:sham-operated group (sham group),pulmonary embolism group (PE group),urokinase thrombolysis grouop (UK group),BQ123 group (BQ group) and urokinase + BQ-123 combination group (UK + BQ group),with 4 dogs in each group.The parameters of the mean pulmonary artery pressure (mPAP),and coronary blood flow (CBF) at different time pointi pre-and post-embolization were recorded and compared,and the serum cTnT level at 6 h post-embolization was determined.Results (1) After pulmonary embolism,mPAP was obviously increased,and at 4 h,mPAP in UK group and UK + BQ group was decreased to (26.67 ± 2.08) and (20.00 ± 2.00) mmHg (1 mmHg =0133 kPa) respectively,remarkably lower than that in PE group (P ＜ 0.05) ; (2) The serum cTnT level at 6 h post-embolization in UK ± BQ group [(611.93 ±97.50) ng/L] was significantly lower than that in UK group [(747.22 ± 62.72) ng/L] and PE group [(900.79 ± 71.11) ng/L] (P ＜0.05) ; (3) The CBF in PE group was obviously declined,and in UK group,BQ group and UK + BQ group,the CBF was increased to varying degrees.UK + BQ group had the greatest increase of CBF and showed statistically significant difference from the other two groups at different time points post-embolization (P ＜ 0.05).Conclusion On the basis of thrombolysis therapy,endothelin-1 receptor antagonist BQ-123 can increase the CBF significantly and relieve the acute myocardial ischemia induced by APE.
