中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
10期
2293-2294
,共2页
叶静%苏敏%梁伟娟%林琳%蔡良真
葉靜%囌敏%樑偉娟%林琳%蔡良真
협정%소민%량위연%림림%채량진
大肠癌%胰岛素样生长因子-1
大腸癌%胰島素樣生長因子-1
대장암%이도소양생장인자-1
Colorectal carcinoma%Insulin like growth factor-1
目的 探讨胰岛素样生长因子-1(IGF-1)在大肠癌患者血清中的表达及其临床意义.方法 采用放射免疫分析法(RIA法)检测32例正常人及62例大肠癌患者手术前血清IGF-1水平,并对42例大肠癌患者手术前后血清IGF-1水平进行比较.结果 血清IGF-1水平与大肠癌患者临床分期、细胞分化程度明显相关,与大肠癌患者性别、年龄无明显相关;大肠癌患者血清IGF-1水平[(255.85 ±56.59) μg/L]明显高于正常对照组[(155.04 ±21.37) μg/L],两者差异有统计学意义(P＜0.01);Ⅳ期大肠癌患者血清IGF-1水平[(309.09 ±50.95) 上g/L]明显高于Ⅲ期患者[(274.40±44.47) μg/L]、Ⅲ期患者明显高于Ⅱ期患者[(236.17 ±35.36) μg/L]、Ⅱ期患者明显高于Ⅰ期患者[(201.50 ±38.51) μg/L]、Ⅰ期患者明显高于正常对照组,两者差异有统计学意义(P＜0.05);肿瘤细胞分化程度较差(低分化腺癌、印戒细胞癌、黏液腺癌)大肠癌患者血清IGF-1水平[(272.60±53.80) μg/L]明显高于肿瘤细胞分化程度较好(高分化腺癌、中分化腺癌)者[(232.65±52.89) μg/L],两者差异有统计学意义(P＜0.05),大肠癌患者术后血清IGF-1水平[(229.83±46.08) μg/L]明显低于术前[(235.24 ±45.98) μg/L],两者差异有统计学意义(P＜0.01).结论 血清IGF-1可能与大肠癌的发生发展有关.
目的 探討胰島素樣生長因子-1(IGF-1)在大腸癌患者血清中的錶達及其臨床意義.方法 採用放射免疫分析法(RIA法)檢測32例正常人及62例大腸癌患者手術前血清IGF-1水平,併對42例大腸癌患者手術前後血清IGF-1水平進行比較.結果 血清IGF-1水平與大腸癌患者臨床分期、細胞分化程度明顯相關,與大腸癌患者性彆、年齡無明顯相關;大腸癌患者血清IGF-1水平[(255.85 ±56.59) μg/L]明顯高于正常對照組[(155.04 ±21.37) μg/L],兩者差異有統計學意義(P＜0.01);Ⅳ期大腸癌患者血清IGF-1水平[(309.09 ±50.95) 上g/L]明顯高于Ⅲ期患者[(274.40±44.47) μg/L]、Ⅲ期患者明顯高于Ⅱ期患者[(236.17 ±35.36) μg/L]、Ⅱ期患者明顯高于Ⅰ期患者[(201.50 ±38.51) μg/L]、Ⅰ期患者明顯高于正常對照組,兩者差異有統計學意義(P＜0.05);腫瘤細胞分化程度較差(低分化腺癌、印戒細胞癌、黏液腺癌)大腸癌患者血清IGF-1水平[(272.60±53.80) μg/L]明顯高于腫瘤細胞分化程度較好(高分化腺癌、中分化腺癌)者[(232.65±52.89) μg/L],兩者差異有統計學意義(P＜0.05),大腸癌患者術後血清IGF-1水平[(229.83±46.08) μg/L]明顯低于術前[(235.24 ±45.98) μg/L],兩者差異有統計學意義(P＜0.01).結論 血清IGF-1可能與大腸癌的髮生髮展有關.
목적 탐토이도소양생장인자-1(IGF-1)재대장암환자혈청중적표체급기림상의의.방법 채용방사면역분석법(RIA법)검측32례정상인급62례대장암환자수술전혈청IGF-1수평,병대42례대장암환자수술전후혈청IGF-1수평진행비교.결과 혈청IGF-1수평여대장암환자림상분기、세포분화정도명현상관,여대장암환자성별、년령무명현상관;대장암환자혈청IGF-1수평[(255.85 ±56.59) μg/L]명현고우정상대조조[(155.04 ±21.37) μg/L],량자차이유통계학의의(P＜0.01);Ⅳ기대장암환자혈청IGF-1수평[(309.09 ±50.95) 상g/L]명현고우Ⅲ기환자[(274.40±44.47) μg/L]、Ⅲ기환자명현고우Ⅱ기환자[(236.17 ±35.36) μg/L]、Ⅱ기환자명현고우Ⅰ기환자[(201.50 ±38.51) μg/L]、Ⅰ기환자명현고우정상대조조,량자차이유통계학의의(P＜0.05);종류세포분화정도교차(저분화선암、인계세포암、점액선암)대장암환자혈청IGF-1수평[(272.60±53.80) μg/L]명현고우종류세포분화정도교호(고분화선암、중분화선암)자[(232.65±52.89) μg/L],량자차이유통계학의의(P＜0.05),대장암환자술후혈청IGF-1수평[(229.83±46.08) μg/L]명현저우술전[(235.24 ±45.98) μg/L],량자차이유통계학의의(P＜0.01).결론 혈청IGF-1가능여대장암적발생발전유관.
Objective To explore the serum expression of insulin like growth factor-1 (IGF-1) in patients with colorectal carcinoma and its clinical significance.Methods The level of serum IGF-1 was measured by radioimmunoassay (RIA) in 32 cases of normal control subjects and 62 cases of colorectal carcinoma,and compared in 42 patients with colorectal carcinoma before and after operation.Results The serum IGF-1 was correlated with with clinical stage and histological grade,but not with sex and age in patients with colorectal carcinoma.The level of serum IGF-1 was elevated in all subgroups of patients with colorectal carcinoma [(255.85 ± 56.59) μg/L] compared to the controls [(155.04 ± 21.37) μg/L] (P ＜0.01).The serum IGF-1 level in stage Ⅳ [(309.09 ±50.95) μg/L] was higher than that in stage Ⅲ [(274.40 ±44.47) μg/L] (P ＜0.05),that in stage Ⅲ was higher than that in stage Ⅱ [(236.17 ± 35.36) μg/L] (P ＜0.05),and in stage Ⅱ it was higher than in stage Ⅰ [(201.50 ±38.51) μg/L] (P ＜ 0.05),and that in stage Ⅰ was higher than that in normal controls (P ＜ 0.01).The levels of serum IGF-1 were significantly higher in the cases of poorly differentiated adenocarcinoma,signet-ring cell carcinoma and mucoid carcinoma [(272.60 ± 53.80) μg/L] than those in the cases of well and moderately differentiated carcinoma [(232.65 ± 52.89) μg/L] (P ＜ 0.05).The serum IGF-1 level was obviously reduced in patients with colorectal carcinoma after operation (P ＜ 0.01).Conclusion These results suggest that serum IGF-1 may be involved in the occurrence and development of colorectal carcinoma.
