中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
10期
2295-2297
,共3页
戚诚%闫长青%刘三光%瞿长宝%赵晓东%张建生
慼誠%閆長青%劉三光%瞿長寶%趙曉東%張建生
척성%염장청%류삼광%구장보%조효동%장건생
胰腺肿瘤%血管抑素%内皮抑素
胰腺腫瘤%血管抑素%內皮抑素
이선종류%혈관억소%내피억소
Pancreatic carcinoma%Angiostatin%Endostatin
目的 探讨胰腺癌患者外周血抑血管生成因子血管抑素及内皮抑素的浓度变化与临床病理特征之间的关系.方法 酶联免疫吸附试验测定胰腺癌可切除患者60例、胰腺癌不可切除患者43例、健康人30例外周血血管抑素及内皮抑素浓度,分析血管抑素及内皮抑素浓度与胰腺癌患者性别、年龄、病理分级、肿瘤大小、淋巴结及远处转移、血管侵犯及临床分期的关系.结果 对照组和胰腺癌组外周血内皮抑素浓度分别为(35.1±5.4)、(83.9±16.1)μg/L,血管抑素浓度分别为(2.4±1.5)、(10.1 ±4.9)nmol/L;可切除组较不可切除组及术后1周内皮抑素浓度分别为(61.9±11.4)、(102.0±20.3)、(31.2±2.9)μg/L,血管抑素浓度分别为(8.1±4.9)、(16.3±7.8)、(2.4±0.7) nmol/L,差异均有统计学意义(P<0.05);血管抑素与血管侵袭及肿瘤大小相关.结论 抑血管生成因子与胰腺癌不同时期的血管生成调控密切相关.
目的 探討胰腺癌患者外週血抑血管生成因子血管抑素及內皮抑素的濃度變化與臨床病理特徵之間的關繫.方法 酶聯免疫吸附試驗測定胰腺癌可切除患者60例、胰腺癌不可切除患者43例、健康人30例外週血血管抑素及內皮抑素濃度,分析血管抑素及內皮抑素濃度與胰腺癌患者性彆、年齡、病理分級、腫瘤大小、淋巴結及遠處轉移、血管侵犯及臨床分期的關繫.結果 對照組和胰腺癌組外週血內皮抑素濃度分彆為(35.1±5.4)、(83.9±16.1)μg/L,血管抑素濃度分彆為(2.4±1.5)、(10.1 ±4.9)nmol/L;可切除組較不可切除組及術後1週內皮抑素濃度分彆為(61.9±11.4)、(102.0±20.3)、(31.2±2.9)μg/L,血管抑素濃度分彆為(8.1±4.9)、(16.3±7.8)、(2.4±0.7) nmol/L,差異均有統計學意義(P<0.05);血管抑素與血管侵襲及腫瘤大小相關.結論 抑血管生成因子與胰腺癌不同時期的血管生成調控密切相關.
목적 탐토이선암환자외주혈억혈관생성인자혈관억소급내피억소적농도변화여림상병리특정지간적관계.방법 매련면역흡부시험측정이선암가절제환자60례、이선암불가절제환자43례、건강인30예외주혈혈관억소급내피억소농도,분석혈관억소급내피억소농도여이선암환자성별、년령、병리분급、종류대소、림파결급원처전이、혈관침범급림상분기적관계.결과 대조조화이선암조외주혈내피억소농도분별위(35.1±5.4)、(83.9±16.1)μg/L,혈관억소농도분별위(2.4±1.5)、(10.1 ±4.9)nmol/L;가절제조교불가절제조급술후1주내피억소농도분별위(61.9±11.4)、(102.0±20.3)、(31.2±2.9)μg/L,혈관억소농도분별위(8.1±4.9)、(16.3±7.8)、(2.4±0.7) nmol/L,차이균유통계학의의(P<0.05);혈관억소여혈관침습급종류대소상관.결론 억혈관생성인자여이선암불동시기적혈관생성조공밀절상관.
Objective To investigate the relationship between angiostatin and endostatin serum concentrations and progression of pancreatic carcinoma.Methods 103 patients with pancreatic carcinoma were divided into resectable group (n =60) and unresectable group (n =43).Normal control group (n =30) was set up.The expression and significance of these proangiogenic factors were respectively analyzed in all groups.Results In normal control group and pancreatic carcinoma group,concentrations of endostatin were (35.1 ±5.4) and (83.9 ±16.1) μg/L,and those of angiostatin were (2.4 ±1.5) and (10.1 ± 4.9) nmol/L,respectively.Concentrations of endostatin in resectable,unresectable and post-operation groups were (61.9 ± 11.4),(102.0 ±20.3) and (31.2 ±2.9) μg/L respectively.Concentrations of angiostatin in resectable,unresectable and post-operation groups were (8.1 ± 4.9),(16.3 ± 7.8) and (2.4 ± 0.7) nmol/L respectively.All differences were statistically significant (P < 0.05).Serum angiostatin was correlated with tumor size and vascular invasion.Conclusion Antiangiogenic factors may play important roles in growth,invasion and metastasis of pancreatic cancer.