CAJ | 학술논문

目的探讨G蛋白耦联受体56(GPR56)在人胃癌组织中的表达及其与胃癌生物学特征的关系.方法采用免疫组织化学及Western blot方法检测GPR56蛋白在正常胃黏膜组织及胃癌组织中的表达水平,分析GPR56表达与胃癌临床病理特征的关系.结果 GPR56蛋白在胃癌组织中的表达水平(0.052 3±0.023 4)明显低于癌旁胃黏膜组织(0.063 3±0.027 0)的表达,两者差异有统计学意义(f =3.739,P＜0.01);胃癌组织中GPR56的表达水平与胃癌分化程度、浸润深度和TNM分期密切相关(P＜0.05),与患者性别、年龄、有无淋巴结转移、患者生存率无明显相关(P＞0.05).结论 GPR56在人胃癌组织中表达显著下降,其表达水平与胃癌的侵袭、转移密切相关.
목적 탐토G단백우련수체56(GPR56)재인위암조직중적표체급기여위암생물학특정적관계.방법 채용면역조직화학급Western blot방법검측GPR56단백재정상위점막조직급위암조직중적표체수평,분석GPR56표체여위암림상병리특정적관계.결과 GPR56단백재위암조직중적표체수평(0.052 3±0.023 4)명현저우암방위점막조직(0.063 3±0.027 0)적표체,량자차이유통계학의의(f =3.739,P＜0.01);위암조직중GPR56적표체수평여위암분화정도、침윤심도화TNM분기밀절상관(P＜0.05),여환자성별、년령、유무림파결전이、환자생존솔무명현상관(P＞0.05).결론 GPR56재인위암조직중표체현저하강,기표체수평여위암적침습、전이밀절상관.
Objective To investigate the expression of G protein-coupled receptor 56 (GPR56) in gastric cancer and the correlation between GPR56 expression and its clinical biological characteristics of gastric cancer.Methods Immunohistochemical staining and Western blotting was employed to detect the GPR56 expression both in gastric cancer and its adjacent stomach tissues.The correlation between the GPR56 expression levels and the clinical parameters was analyzed.Results The expression of GPR56 was significantly lower in gastric cancer tissues than in the adjacent normal tissues (0.052 3 ± 0.023 4 vs.0.063 3 ±0.027 0,t =3.739,P ＜0.01).The expression of GPR56 was tightly correlated with histology differentiated degree,depth of infiltration,and TNM stage (P ＜ 0.05).No correlations were found between GPR56 expression and age,gender,lymph nodes metastasis,or survival rate in gastric cancer patients (P ＞ 0.05).Conclusion The GPR56 expression is significantly decreased in gastric cancer as compared with their adjacent normal tissues.The study indicates that the lower expression of GPR56 contributes to the development and metastasis of gastric cancer.