中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
11期
2580-2581
,共2页
钟晖东%李其杰%李斌%黄杰
鐘暉東%李其傑%李斌%黃傑
종휘동%리기걸%리빈%황걸
胶质瘤%CD133%骨桥蛋白%免疫组织化学法
膠質瘤%CD133%骨橋蛋白%免疫組織化學法
효질류%CD133%골교단백%면역조직화학법
Glioma%CD133%Osteopontin%Immunohistochemical method
目的 探讨CD133和骨桥蛋白(OPN)在胶质瘤组织的表达水平及其与胶质瘤病理学特征的关系.方法 应用免疫组织化学法检测55例胶质瘤组织和16例正常脑组织中CD133和OPN表达水平.结果 CD133在胶质瘤组织的阳性表达率为63.64%,明显高于正常脑组织阳性表达率(12.50%),两者差异有统计学意义(P<0.01),OPN在胶质瘤组织的阳性表达率78.18%,明显高于正常脑组织的阳性表达率(6.25%),两者差异有统计学意义(P<0.01);CD133及OPN表达水平与胶质瘤组织学分级明显相关(P<0.05).结论 CD133及OPN的过度表达均反映胶质瘤的生物学特性.
目的 探討CD133和骨橋蛋白(OPN)在膠質瘤組織的錶達水平及其與膠質瘤病理學特徵的關繫.方法 應用免疫組織化學法檢測55例膠質瘤組織和16例正常腦組織中CD133和OPN錶達水平.結果 CD133在膠質瘤組織的暘性錶達率為63.64%,明顯高于正常腦組織暘性錶達率(12.50%),兩者差異有統計學意義(P<0.01),OPN在膠質瘤組織的暘性錶達率78.18%,明顯高于正常腦組織的暘性錶達率(6.25%),兩者差異有統計學意義(P<0.01);CD133及OPN錶達水平與膠質瘤組織學分級明顯相關(P<0.05).結論 CD133及OPN的過度錶達均反映膠質瘤的生物學特性.
목적 탐토CD133화골교단백(OPN)재효질류조직적표체수평급기여효질류병이학특정적관계.방법 응용면역조직화학법검측55례효질류조직화16례정상뇌조직중CD133화OPN표체수평.결과 CD133재효질류조직적양성표체솔위63.64%,명현고우정상뇌조직양성표체솔(12.50%),량자차이유통계학의의(P<0.01),OPN재효질류조직적양성표체솔78.18%,명현고우정상뇌조직적양성표체솔(6.25%),량자차이유통계학의의(P<0.01);CD133급OPN표체수평여효질류조직학분급명현상관(P<0.05).결론 CD133급OPN적과도표체균반영효질류적생물학특성.
Objective To investigate the expression of CD133 and osteopontin (OPN) and their relation to pathological features in human brain glioma.Methods The expression levels of CD133 and OPN in 55 cases of human brain glioma tissues and 16 cases of normal brain tissues were detected by using immunohistochemical method.Results The expression rate of CD133 in brain glioma tissues was higher than that of normal brain tissues (63.64% vs.12.50%,P <0.01),and that of OPN in brain glioma tissues was higher than that of normal brain tissues (78.18% vs.6.25%,P<0.01).The expressions of CD133 and OPN was related to histological grades of glioma (P < 0.05).Conclusion The expressions of CD133 and OPN is closely related to the malignant behaviors of glioma.