国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
17期
2707-2709
,共3页
低分子肝素钙%原发性肾病综合征%高凝状态
低分子肝素鈣%原髮性腎病綜閤徵%高凝狀態
저분자간소개%원발성신병종합정%고응상태
Low molecular weight heparin%Primary nephrotic syndrome%Hypercoagulable state
目的 探讨低分子肝素钙在原发性肾病综合征伴高凝状态患者中的应用价值.方法 选取60例原发性肾病综合征伴高凝状态患者,随机均分为对照组和观察组,对照组给予双嘧达莫片治疗,观察组给予低分子肝素钙治疗.比较两组患者治疗前后尿蛋白定量、血清胆固醇、血清白蛋白、PT、APTT和D-D值的差异.结果 两组患者治疗前各指标比较差异无统计学意义(P＞0.05),治疗后观察组尿蛋白定量、血清胆固醇、血清白蛋白和D-D值均显著优于对照组(P＜0.05),观察组PT和APTT分别为(12.5±2.2)s和(35.9±7.1)s,均显著高于对照组的(10.1±1.9)s和(30.8±7.3)s(P＜0.05).结论 低分子肝素钙治疗原发性肾病综合征伴高凝状态患者疗效确切,可显著改善高凝状态,降低蛋白尿.
目的 探討低分子肝素鈣在原髮性腎病綜閤徵伴高凝狀態患者中的應用價值.方法 選取60例原髮性腎病綜閤徵伴高凝狀態患者,隨機均分為對照組和觀察組,對照組給予雙嘧達莫片治療,觀察組給予低分子肝素鈣治療.比較兩組患者治療前後尿蛋白定量、血清膽固醇、血清白蛋白、PT、APTT和D-D值的差異.結果 兩組患者治療前各指標比較差異無統計學意義(P＞0.05),治療後觀察組尿蛋白定量、血清膽固醇、血清白蛋白和D-D值均顯著優于對照組(P＜0.05),觀察組PT和APTT分彆為(12.5±2.2)s和(35.9±7.1)s,均顯著高于對照組的(10.1±1.9)s和(30.8±7.3)s(P＜0.05).結論 低分子肝素鈣治療原髮性腎病綜閤徵伴高凝狀態患者療效確切,可顯著改善高凝狀態,降低蛋白尿.
목적 탐토저분자간소개재원발성신병종합정반고응상태환자중적응용개치.방법 선취60례원발성신병종합정반고응상태환자,수궤균분위대조조화관찰조,대조조급여쌍밀체막편치료,관찰조급여저분자간소개치료.비교량조환자치료전후뇨단백정량、혈청담고순、혈청백단백、PT、APTT화D-D치적차이.결과 량조환자치료전각지표비교차이무통계학의의(P＞0.05),치료후관찰조뇨단백정량、혈청담고순、혈청백단백화D-D치균현저우우대조조(P＜0.05),관찰조PT화APTT분별위(12.5±2.2)s화(35.9±7.1)s,균현저고우대조조적(10.1±1.9)s화(30.8±7.3)s(P＜0.05).결론 저분자간소개치료원발성신병종합정반고응상태환자료효학절,가현저개선고응상태,강저단백뇨.
Objective To investigate the clinical value of low molecular weight heparin for the treatment of primary nephrotic syndrome associated with a hypercoagulable state.Methods 60 cases of primary nephrotic syndrome associated with a hypercoagulable state in our hospital were randomly divided into control group and observation group.The control group was treated with dipyridamole tablets.The observation group was treated with low molecular weight heparin.The urinary protein,serum cholesterol,albumin,PT,APTT and DD before and after treatment of two groups were compared.Results Each index of two groups before treatment had no significant difference (P ＞ 0.05).The urinary protein,serum cholesterol,albumin and DD of observation group after treatment were significantly better than those of control group (P ＜ 0.05).PT and APTT of observation group were (12.5 ± 2.2)s and (35.9 ± 7.1)s respectively,which were significantly higher than those of control group as (10.1 ± 1.9)s and (30.8 ± 7.3)s (P ＜ 0.05).Conclusion Low molecular weight heparin for primary nephrotic syndrome associated with a hypercoagulable state has exact effect.It can significantly improve hypercoagulable state and reduce proteinuria.
