中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2012年
10期
752-756
,共5页
血液透析%红细胞生成素%C反应蛋白质%pro-hepcidin%血清铁蛋白
血液透析%紅細胞生成素%C反應蛋白質%pro-hepcidin%血清鐵蛋白
혈액투석%홍세포생성소%C반응단백질%pro-hepcidin%혈청철단백
Hemodialysis%Erythropoietin%C reactive proteins%Pro-hepcidin%Ferritin
目的 研究维持性血液透析(MHD)红细胞生成素(EPO)抵抗患者pro-hepcidin与炎性反应和铁代谢的关系.方法 40例MHD患者为研究对象,其中20例EPO低反应和20例EPO正常反应.20例健康体检者为对照组.检测参试者的血红细胞计数(RBC)、血红蛋白(Hb)、网织红细胞计数(Ret)、红细胞比容(Hct)、血清铁蛋白(SF)、转铁蛋白(TF)、血清铁和总铁结合力、转铁蛋白饱和度(TSAT)(TSAT=血清铁/总铁结合力)、血清pro-hepcidin、血清超敏C反应蛋白(hs-CRP),并比较组间差异.Pearson相关法分析pro-hepcidin的影响因素.ROC曲线预测pro-hepcidin对EPO抵抗的价值.结果 MHD患者SF、血清pro-hepcidin、hs-CRP显著高于健康对照者(P＜0.01),TF显著低于健康对照者(P＜0.05).EPO抵抗患者血清铁蛋白、血清pro-hepcidin、hs-CRP明显高于反应正常的患者(P＜0.01).Pearson相关分析显示MHD EPO抵抗患者血清pro-hepcidin水平与血清铁蛋白(r=0.843,P=0.000)和hs-CRP(r=0.695,P=0.001)呈正相关.预测EPO抵抗的ROC曲线显示,pro-hepcidin、SF、hs-CRP曲线下面积分别为0.713、0.769和0.958.结论 EPO抵抗与炎性反应和铁代谢相关.血清pro-hepcidin、SF、hs-CRP有可能成为EPO抵抗的标志.
目的 研究維持性血液透析(MHD)紅細胞生成素(EPO)牴抗患者pro-hepcidin與炎性反應和鐵代謝的關繫.方法 40例MHD患者為研究對象,其中20例EPO低反應和20例EPO正常反應.20例健康體檢者為對照組.檢測參試者的血紅細胞計數(RBC)、血紅蛋白(Hb)、網織紅細胞計數(Ret)、紅細胞比容(Hct)、血清鐵蛋白(SF)、轉鐵蛋白(TF)、血清鐵和總鐵結閤力、轉鐵蛋白飽和度(TSAT)(TSAT=血清鐵/總鐵結閤力)、血清pro-hepcidin、血清超敏C反應蛋白(hs-CRP),併比較組間差異.Pearson相關法分析pro-hepcidin的影響因素.ROC麯線預測pro-hepcidin對EPO牴抗的價值.結果 MHD患者SF、血清pro-hepcidin、hs-CRP顯著高于健康對照者(P＜0.01),TF顯著低于健康對照者(P＜0.05).EPO牴抗患者血清鐵蛋白、血清pro-hepcidin、hs-CRP明顯高于反應正常的患者(P＜0.01).Pearson相關分析顯示MHD EPO牴抗患者血清pro-hepcidin水平與血清鐵蛋白(r=0.843,P=0.000)和hs-CRP(r=0.695,P=0.001)呈正相關.預測EPO牴抗的ROC麯線顯示,pro-hepcidin、SF、hs-CRP麯線下麵積分彆為0.713、0.769和0.958.結論 EPO牴抗與炎性反應和鐵代謝相關.血清pro-hepcidin、SF、hs-CRP有可能成為EPO牴抗的標誌.
목적 연구유지성혈액투석(MHD)홍세포생성소(EPO)저항환자pro-hepcidin여염성반응화철대사적관계.방법 40례MHD환자위연구대상,기중20례EPO저반응화20례EPO정상반응.20례건강체검자위대조조.검측삼시자적혈홍세포계수(RBC)、혈홍단백(Hb)、망직홍세포계수(Ret)、홍세포비용(Hct)、혈청철단백(SF)、전철단백(TF)、혈청철화총철결합력、전철단백포화도(TSAT)(TSAT=혈청철/총철결합력)、혈청pro-hepcidin、혈청초민C반응단백(hs-CRP),병비교조간차이.Pearson상관법분석pro-hepcidin적영향인소.ROC곡선예측pro-hepcidin대EPO저항적개치.결과 MHD환자SF、혈청pro-hepcidin、hs-CRP현저고우건강대조자(P＜0.01),TF현저저우건강대조자(P＜0.05).EPO저항환자혈청철단백、혈청pro-hepcidin、hs-CRP명현고우반응정상적환자(P＜0.01).Pearson상관분석현시MHD EPO저항환자혈청pro-hepcidin수평여혈청철단백(r=0.843,P=0.000)화hs-CRP(r=0.695,P=0.001)정정상관.예측EPO저항적ROC곡선현시,pro-hepcidin、SF、hs-CRP곡선하면적분별위0.713、0.769화0.958.결론 EPO저항여염성반응화철대사상관.혈청pro-hepcidin、SF、hs-CRP유가능성위EPO저항적표지.
Objective To examine the association of pro-hepcidin with iron metabolism and inflammation in maintenance hemodialysis (MHD) patients with erythropoietin (EPO) resistance.Methods Forty MHD patients and twenty healthy controls were enrolled in the study.Among MHD patients,20 were hyporesponsive to EPO therapy and 20 were normal responsive to EPO therapy.Complete blood red cell count (RBC),Hb concentration,hematocrit (Hct),reticulocyte count (Ret),and serum ferritin (SF),serum iron (Fe),total ironbinding capacity (TIBC),saturation rate of transferrin (TSAT),transferrin (TF),hyper-sensitive C-reactive protein (hs-CRP),pro-hepcidin were measured in all the patients and controls.Differences were compared between groups.Influencing factors were analyzed by Pearson correlation.Predicting value of pro-hepcidin was investigated by ROC curve.Results Serum levels of SF,pro-hepcidin and hs-CRP were significantly higher in MHD patients than those in healthy controls (P＜0.01),while serum TF was lower in MHD patients (P＜0.05).Serum levels of SF,pro-hepcidin and hs-CRP were significantly higher in EPO resistant patients as compared to normal responsive cases (P＜0.01).Serum prohepcidin level was positively correlated with SF (r=0.843,P=0.000) and hs-CRP (r=0.695,P=0.001).In predicting EPO resistance,area under ROC curve of pro-hepcidin,SF and hs-CRP was 0.713,0.769 and 0.958 respectively.Conclusions EPO resistance is correlated with inflammation and iron metabolism.Serum pro-hepcidin,SF and hs-CRP may be used as markers of EPO resistance in MHD patients.
