CAJ | 학술논문

目的探讨分类树模型分析2型糖尿病早期肾损害的相关影响因素,为进一步的预防和治疗提供参考依据.方法选取临床资料完善的2型糖尿病住院患者601例,据估算肾小球滤过率(eGFR)分期及尿白蛋白定量诊断分为2型糖尿病组(418例)和糖尿病早期肾损害组(183例).记录患者的相关临床资料,采用Exhaustive CHAID分类树算法分析2型糖尿病出现微量蛋白尿的主要影响因素.结果分类树模型从34个候选变量中筛选出6个重要解释变量,分别是纤维蛋白原、高血压病史、视网膜病变、胱抑素水平、收缩压、周围神经病变,与糖尿病早期肾损害的发病风险相关,纤维蛋白原升高是最主要的相关因素.结论采用分类树模型分析糖尿病早期肾损害主要相关影响因素是可行的,多因素共同作用增加发病风险,可以为制定预防、治疗方案提供依据.
목적 탐토분류수모형분석2형당뇨병조기신손해적상관영향인소,위진일보적예방화치료제공삼고의거.방법 선취림상자료완선적2형당뇨병주원환자601례,거고산신소구려과솔(eGFR)분기급뇨백단백정량진단분위2형당뇨병조(418례)화당뇨병조기신손해조(183례).기록환자적상관림상자료,채용Exhaustive CHAID분류수산법분석2형당뇨병출현미량단백뇨적주요영향인소.결과 분류수모형종34개후선변량중사선출6개중요해석변량,분별시섬유단백원、고혈압병사、시망막병변、광억소수평、수축압、주위신경병변,여당뇨병조기신손해적발병풍험상관,섬유단백원승고시최주요적상관인소.결론 채용분류수모형분석당뇨병조기신손해주요상관영향인소시가행적,다인소공동작용증가발병풍험,가이위제정예방、치료방안제공의거.
Objective To analyze the impact factors for early renal damage in type 2 diabetic patients by the classification tree model.Methods A total of 601 patients with type 2 diabetes were enrolled.According to glomerular filtration rates and urine albumin quantification,the patients were divided into type 2 diabetes group (418 cases) and early diabetic renal damage group (183 cases).The clinical data of the patients were recorded to analyze the main influential factors for the microalbuminuria of type 2 diabetic patients using the Exhaustive CHAID classification tree algorithm.Results Six important explanatory variables were screened out by the classification tree model from the 34 candidate variables related to early renal damage,including fibrinogen,history of hypertension,retinopathy,Cys C levels,SBP and peripheral neuropathy.Elevated fibrinogen was the main factor.Conclusion The classification tree model can analyze the major influential factors of early renal damage in type 2 diabetic patients effectively,and it can help develop the prevention and treatment methods.