中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2013年
11期
812-817
,共6页
张坤英%刘惠兰%段晓峰%李国刚
張坤英%劉惠蘭%段曉峰%李國剛
장곤영%류혜란%단효봉%리국강
血液透析%骨调素%甲状旁腺素%颈动脉疾病
血液透析%骨調素%甲狀徬腺素%頸動脈疾病
혈액투석%골조소%갑상방선소%경동맥질병
Hemodialysisy%Osteopontin%Parathyroid hormone%Carotid artery diseases
目的 通过测定维持性血液透析(MHD)患者血清骨调素(OPN)和全段甲状旁腺素(iPTH)水平并分析其相关性,探讨二者在血液透析患者颈动脉钙化发生发展中的作用.方法 选取稳定透析的MHD患者共48例和健康对照28例为研究对象.抽取外周血,酶联免疫吸附法(ELISA)测定血清OPN水平,同时检测血清iPTH、颈总动脉分叉处钙化斑块数目及相关临床参数,收集基线资料.对OPN与iPTH及相关参数进行相关和回归分析.结果 MHD组透析前血OPN水平[(137.4±80.8) ng/L比(31.6±6.7) ng/L,P＜0.01]和iPTH水平[(456.4±326.4) ng/L比(66.9±19.3) ng/L,P＜0.01]较健康对照组高;MHD组颈动脉分叉处钙化斑块数目也较对照组高(P＜0.01).MHD组透前血OPN和iPTH水平呈正相关(r=0.620,P＜0.01).按颈动脉分叉处钙化斑块数目将患者三等分,钙化斑块数目越多的患者,血清OPN、iPTH水平越高.多元线性回归分析校正各种混杂因素后,OPN仍与iPTH呈正相关[β=0.468,95％CI (0.036,0.195),t=2.936,P=0.005].结论 血液透析患者普遍存在OPN和iPTH水平升高,且OPN和iPTH水平呈正相关,二者均和颈总动脉分叉处钙化斑块数目密切相关.提示OPN和iPTH相互影响,共同参与了颈动脉钙化的发生发展过程.
目的 通過測定維持性血液透析(MHD)患者血清骨調素(OPN)和全段甲狀徬腺素(iPTH)水平併分析其相關性,探討二者在血液透析患者頸動脈鈣化髮生髮展中的作用.方法 選取穩定透析的MHD患者共48例和健康對照28例為研究對象.抽取外週血,酶聯免疫吸附法(ELISA)測定血清OPN水平,同時檢測血清iPTH、頸總動脈分扠處鈣化斑塊數目及相關臨床參數,收集基線資料.對OPN與iPTH及相關參數進行相關和迴歸分析.結果 MHD組透析前血OPN水平[(137.4±80.8) ng/L比(31.6±6.7) ng/L,P＜0.01]和iPTH水平[(456.4±326.4) ng/L比(66.9±19.3) ng/L,P＜0.01]較健康對照組高;MHD組頸動脈分扠處鈣化斑塊數目也較對照組高(P＜0.01).MHD組透前血OPN和iPTH水平呈正相關(r=0.620,P＜0.01).按頸動脈分扠處鈣化斑塊數目將患者三等分,鈣化斑塊數目越多的患者,血清OPN、iPTH水平越高.多元線性迴歸分析校正各種混雜因素後,OPN仍與iPTH呈正相關[β=0.468,95％CI (0.036,0.195),t=2.936,P=0.005].結論 血液透析患者普遍存在OPN和iPTH水平升高,且OPN和iPTH水平呈正相關,二者均和頸總動脈分扠處鈣化斑塊數目密切相關.提示OPN和iPTH相互影響,共同參與瞭頸動脈鈣化的髮生髮展過程.
목적 통과측정유지성혈액투석(MHD)환자혈청골조소(OPN)화전단갑상방선소(iPTH)수평병분석기상관성,탐토이자재혈액투석환자경동맥개화발생발전중적작용.방법 선취은정투석적MHD환자공48례화건강대조28례위연구대상.추취외주혈,매련면역흡부법(ELISA)측정혈청OPN수평,동시검측혈청iPTH、경총동맥분차처개화반괴수목급상관림상삼수,수집기선자료.대OPN여iPTH급상관삼수진행상관화회귀분석.결과 MHD조투석전혈OPN수평[(137.4±80.8) ng/L비(31.6±6.7) ng/L,P＜0.01]화iPTH수평[(456.4±326.4) ng/L비(66.9±19.3) ng/L,P＜0.01]교건강대조조고;MHD조경동맥분차처개화반괴수목야교대조조고(P＜0.01).MHD조투전혈OPN화iPTH수평정정상관(r=0.620,P＜0.01).안경동맥분차처개화반괴수목장환자삼등분,개화반괴수목월다적환자,혈청OPN、iPTH수평월고.다원선성회귀분석교정각충혼잡인소후,OPN잉여iPTH정정상관[β=0.468,95％CI (0.036,0.195),t=2.936,P=0.005].결론 혈액투석환자보편존재OPN화iPTH수평승고,차OPN화iPTH수평정정상관,이자균화경총동맥분차처개화반괴수목밀절상관.제시OPN화iPTH상호영향,공동삼여료경동맥개화적발생발전과정.
Objective To explore possible associations between osteopontin(OPN) and intact parathyroid hormone(iPTH),to investigate effects of them on the progression of carotid artery calcification in patients receiving long-term hemodialysis.Methods Forty-eight maintenance hemodialysis (MHD) patients and 28 age-and sex-matched healthy volunteers were recruited.The concentration of OPN in peripheral blood was determined by enzyme linked immunosorbent assay (ELISA).Levels of iPTH and presence of plaques in the common carotid arteries were also measured.The demographics were recorded.Results Compared with controls,levels of OPN[(137.4±80.8) ng/L vs (31.6±6.7) ng/L,P ＜ 0.01] and iPTH[(456.4±326.4) ng/L vs (66.9±19.3) ng/L,P ＜ 0.01] were higher in MHD patients before hemodialysis,the numbers of calcific plaques in the common carotid arteries were increased in MHD patients (P ＜ 0.01).There was a positive correlation between pre-dialysis OPN levels and iPTH levels (r =0.620,P ＜ 0.01) in MHD patients.Higher levels of OPN and iPTH correlated with greater numbers of calcific plaques in the common carotid arteries after division into three subgroups of MHD patients based on calcific plaques.In multiple linear regression analysis,the correlation between the pre-dialysis OPN and iPTH levels remained the same even if adjusting for confounding effects[β =0.468,95％C1 (0.036,0.195),t =2.936,P =0.005].Conclusion OPN level is positively correlated with iPTH level in hemodialysis patients,which suggesting that both of them play important roles in the progression of carotid artery calcification.
