中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2012年
12期
728-731
,共4页
赵静%梁军%邹彩艳%王玉%卞文%祁禄%宋怀东
趙靜%樑軍%鄒綵豔%王玉%卞文%祁祿%宋懷東
조정%량군%추채염%왕옥%변문%기록%송부동
血红蛋白A,糖基化%动脉粥样硬化%交互作用%年龄%血压
血紅蛋白A,糖基化%動脈粥樣硬化%交互作用%年齡%血壓
혈홍단백A,당기화%동맥죽양경화%교호작용%년령%혈압
Hemoglobin A,glycosylated%Arteriosclerosis%Interaction%Age%Blood pressure
目的 探讨中国成年非糖尿病者糖化血红蛋白(HbA1c)水平与早期动脉粥样硬化的关系,评估年龄、血压、血脂等因素对该关系的影响.方法 选择2011年6月至2012年3月徐州地区健康体检人群5514名,年龄19 ～90岁,对符合要求的5098名非糖尿病者进行体格检查并抽取空腹血进行生化检测,测定颈-股动脉脉搏波传导速度(c-fPWV)水平并进行分析.计数资料间的比较采用X2检验,组间比较采用单因素方差分析.交互作用检测将在模型中引入交互作用相,交互关系的验证用似然比检验(LRT).结果 随着HbA1c、空腹血糖、口服葡萄糖耐量试验(OGTT)2 h血糖水平升高,c-fPWV呈显著上升趋势(趋势P值＜0.0001),校正年龄、性别、体质指数(BMI)、血压、心率和血脂后,c-fPWV仍随着HbA1c水平的升高而升高(趋势P值=0.004).此外,HbA1c与年龄存在交互作用而对c-fPWV产生影响(P＜0.000l),当研究对象年龄≥60岁、收缩压≥140 mm Hg(1 mmHg =0.133 kPa)和(或)舒张压≥90 mm Hg时,c-fPWV随着HbA1c水平的升高而呈显著上升趋势(趋势P值分别为0.004、0.028).结论 非糖尿病者HbA1c水平与早期动脉粥样硬化具有相关性,并独立于其他代谢危险因素.高龄和高血压对HbA1c与c-fPWV之间的相关性起修饰作用.
目的 探討中國成年非糖尿病者糖化血紅蛋白(HbA1c)水平與早期動脈粥樣硬化的關繫,評估年齡、血壓、血脂等因素對該關繫的影響.方法 選擇2011年6月至2012年3月徐州地區健康體檢人群5514名,年齡19 ～90歲,對符閤要求的5098名非糖尿病者進行體格檢查併抽取空腹血進行生化檢測,測定頸-股動脈脈搏波傳導速度(c-fPWV)水平併進行分析.計數資料間的比較採用X2檢驗,組間比較採用單因素方差分析.交互作用檢測將在模型中引入交互作用相,交互關繫的驗證用似然比檢驗(LRT).結果 隨著HbA1c、空腹血糖、口服葡萄糖耐量試驗(OGTT)2 h血糖水平升高,c-fPWV呈顯著上升趨勢(趨勢P值＜0.0001),校正年齡、性彆、體質指數(BMI)、血壓、心率和血脂後,c-fPWV仍隨著HbA1c水平的升高而升高(趨勢P值=0.004).此外,HbA1c與年齡存在交互作用而對c-fPWV產生影響(P＜0.000l),噹研究對象年齡≥60歲、收縮壓≥140 mm Hg(1 mmHg =0.133 kPa)和(或)舒張壓≥90 mm Hg時,c-fPWV隨著HbA1c水平的升高而呈顯著上升趨勢(趨勢P值分彆為0.004、0.028).結論 非糖尿病者HbA1c水平與早期動脈粥樣硬化具有相關性,併獨立于其他代謝危險因素.高齡和高血壓對HbA1c與c-fPWV之間的相關性起脩飾作用.
목적 탐토중국성년비당뇨병자당화혈홍단백(HbA1c)수평여조기동맥죽양경화적관계,평고년령、혈압、혈지등인소대해관계적영향.방법 선택2011년6월지2012년3월서주지구건강체검인군5514명,년령19 ～90세,대부합요구적5098명비당뇨병자진행체격검사병추취공복혈진행생화검측,측정경-고동맥맥박파전도속도(c-fPWV)수평병진행분석.계수자료간적비교채용X2검험,조간비교채용단인소방차분석.교호작용검측장재모형중인입교호작용상,교호관계적험증용사연비검험(LRT).결과 수착HbA1c、공복혈당、구복포도당내량시험(OGTT)2 h혈당수평승고,c-fPWV정현저상승추세(추세P치＜0.0001),교정년령、성별、체질지수(BMI)、혈압、심솔화혈지후,c-fPWV잉수착HbA1c수평적승고이승고(추세P치=0.004).차외,HbA1c여년령존재교호작용이대c-fPWV산생영향(P＜0.000l),당연구대상년령≥60세、수축압≥140 mm Hg(1 mmHg =0.133 kPa)화(혹)서장압≥90 mm Hg시,c-fPWV수착HbA1c수평적승고이정현저상승추세(추세P치분별위0.004、0.028).결론 비당뇨병자HbA1c수평여조기동맥죽양경화구유상관성,병독립우기타대사위험인소.고령화고혈압대HbA1c여c-fPWV지간적상관성기수식작용.
Objective To explore the association of glycated hemoglobin A1c (HbAlc) in non-diabetes with the early stage of arteriosclerosis,and evaluate the modification effects of age,blood pressure,lipids et al in non-diabetes Chinese adults.Methods We performed a community-based health examination survey for 5514 individuals (19 90 yrs old) who were randomly selected from residents living in the urban area of Xuzhou city.In total 5098 non-diabetes individuals were included in the final analyses,physical measurements,biomarkers and carotid-to-femoral pulse wave velocity (c-fPWV) were detected.Data management and statistical analysis were conducted using SPSS 15.0 statistical software,Chi-square test were used to calculate the count data,comparisons between groups were assessed by one-way analysis of variance.Results Along with the increased HbA1c,fasting plasma glucose and oral glucose tolerance test (OGTT) 2 h glucose levels,the prevalence of c-fPWV was significantly higher (P for trend ＜ 0.0001),adjusting for age,sex,body mass index(BMI),blood pressure and lipids,c-fPWV was still along with the increased HbA1c (P for trend =0.004).In addition,HbA1c significantly interacted with age to affect cfPWV (P for interaction ＜ 0.0001).The association was stronger in subjects who were elder (≥60 yrs; P for trend =0.004) and had higher blood pressure (systolic blood pressure ≥ 140 mm Hg(1 mm Hg =0.133kPa) and (or) diastolic blood pressure ≥ 90 mm Hg (P for trend =0.028)).Conclusions In non-diabetes,HbA1c is associated with arteriosclerosis which independent of metabolic risk factors.Age and blood pressure may modify the associations between HbA1c and c-fPWV.
