CAJ | 학술논문

目的本研究探讨2型糖尿病(T2DM)患者血浆成纤维细胞生长凶子21(FGF-21)水平变化及其与体质指数(BMI)、血糖、血浆胰岛素水平等因素的关系.方法选取2013年1月至7月于首都医科大学附属北京朝阳医院内分泌科就诊患者180例为研究对象,分为新诊断T2DM组(DM组,136例),糖耐量受损组(IGR组,44例),另选取同期体检健康志愿者52名为对照组(NDM组),应用ELISA方法测定了上述人群的血浆FGF-21水平,并分析血浆FGF21水平与BMI、血糖、血脂、血浆胰岛素、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(HOMA-ISI)等的关系.组间比较采用独立样本t检验进行统计学分析.采用Pearson法进行相关性分析,相关因素分析采用多元线性回归分析法.结果初诊T2DM患者血浆FGF21水平明显高于健康对照组(319.2±2.5比223.1± 1.4,t=2.804,P＜0.05).初诊T2DM患者、健康对照组血浆FGF-21水平均与TG水平呈正相关(r=0.26、0.38,均P＜0.05);在IGR组,血浆FGF-21水平与BMI呈正相关(r=0.33,P＜0.05).多元回归分析表明HOMA-ISI是影响T2DM患者血浆FGF21水平的独立相关因素.结论初发2型糖尿病患者血浆FGF21水平的改变与甘油三酯水平及胰岛素抵抗有关.
목적 본연구탐토2형당뇨병(T2DM)환자혈장성섬유세포생장흉자21(FGF-21)수평변화급기여체질지수(BMI)、혈당、혈장이도소수평등인소적관계.방법 선취2013년1월지7월우수도의과대학부속북경조양의원내분비과취진환자180례위연구대상,분위신진단T2DM조(DM조,136례),당내량수손조(IGR조,44례),령선취동기체검건강지원자52명위대조조(NDM조),응용ELISA방법측정료상술인군적혈장FGF-21수평,병분석혈장FGF21수평여BMI、혈당、혈지、혈장이도소、이도소저항지수(HOMA-IR)、이도소민감지수(HOMA-ISI)등적관계.조간비교채용독립양본t검험진행통계학분석.채용Pearson법진행상관성분석,상관인소분석채용다원선성회귀분석법.결과 초진T2DM환자혈장FGF21수평명현고우건강대조조(319.2±2.5비223.1± 1.4,t=2.804,P＜0.05).초진T2DM환자、건강대조조혈장FGF-21수평균여TG수평정정상관(r=0.26、0.38,균P＜0.05);재IGR조,혈장FGF-21수평여BMI정정상관(r=0.33,P＜0.05).다원회귀분석표명HOMA-ISI시영향T2DM환자혈장FGF21수평적독립상관인소.결론 초발2형당뇨병환자혈장FGF21수평적개변여감유삼지수평급이도소저항유관.
Objective To investigate the relationship between plasma fibroblast growth factor 21 (FGF-21) levels and body mass index(BMI),plasma glucose,plasma insulin levels,as well as other factors in newly diagnosed type 2 diabetes mellitus (T2DM).Methods 180 subjects who visited Department of endocrinology,Chaoyang Hospital,Capital Medical University from January to July in 2013 were enrolledand divided into newly diagnosed T2DM group (DM group,n=136) and Impaired glucose tolerance (IGR group,n=44).We selected 52 healthy volunteer as control group (NCM group).Plasma FGF-21 levels were determined by ELISA.The association between plasma FGF-21 levels and BMI,plasma glucose,blood lipids,plasma insulin levels,homeostasis model assessment of insulin resistance (HOMA-IR),homeostasis model assessment of insulin sensitivity index(HOMA-ISI) and other factors were also analyzed.We use independent-samples t test,Pearson's correlations,multivariate linear regression analysis.Results Plasma FGF-21 levels in newly diagnosed T2DM patients were significantly higher than those of healthy individuals (319.2±2.5 vs 223.09±1.43,t=2.804,P＜0.05).Plasma FGF-21 levels positively correlated with triglyceride (TG) in newly diagnosed T2DM patients and healthy individuals (r=0.26,0.38,respectively,P＜0.05 all above).Plasma FGF-21 levels positively correlated with BMI in IGR group (r=0.33,P＜0.05).Multiple regression analysis suggested that HOMA-ISI was an independent related factor influencing plasma FGF-21 levels.Conclusion FGF-21 in newly diagnosed T2DM patients is associated with triglyceride levels,insulin resistance.