中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2013年
3期
221-224
,共4页
郭俊超%展翰翔%张太平%赵玉沛
郭俊超%展翰翔%張太平%趙玉沛
곽준초%전한상%장태평%조옥패
胰腺肿瘤%癌,腺泡细胞%诊断%消化系统外科手术
胰腺腫瘤%癌,腺泡細胞%診斷%消化繫統外科手術
이선종류%암,선포세포%진단%소화계통외과수술
Pancreatic neoplasms%Carcinoma,acinar cell%Diagnosis%Digestive system surgical procedures
目的 分析总结胰腺腺泡细胞癌临床特点,探讨其诊断方法及外科治疗策略.方法 总结2002年1月至2012年1月接受手术治疗的胰腺腺泡细胞癌患者的临床资料,对其临床表现、诊断、治疗、预后进行分析.结果 共收集到具有完整病例资料的胰腺腺泡细胞癌患者6例,其中男性3例,女性3例；年龄30～ 63岁,平均年龄47.8岁.6例患者中,腹痛、消瘦、背痛、恶心、呕吐为其主要临床表现.2例患者CA19-9及CA24-2明显升高.CT、MRI及DSA为主要影像学诊断手段,但术前无1例诊断为胰腺腺泡细胞癌,均为术后病理证实.手术切除率相对较高,但手术时间长、术中出血量大及可能联合多器官切除.术后平均随访60个月,平均生存期为(32±8)个月.结论 胰腺腺泡细胞癌的临床特点及生物学行为有别于导管腺癌,其一些相对特殊的临床表现及影像学改变有助于术前定性诊断.该疾病手术切除率高,预后较好,治疗应持积极态度.
目的 分析總結胰腺腺泡細胞癌臨床特點,探討其診斷方法及外科治療策略.方法 總結2002年1月至2012年1月接受手術治療的胰腺腺泡細胞癌患者的臨床資料,對其臨床錶現、診斷、治療、預後進行分析.結果 共收集到具有完整病例資料的胰腺腺泡細胞癌患者6例,其中男性3例,女性3例；年齡30～ 63歲,平均年齡47.8歲.6例患者中,腹痛、消瘦、揹痛、噁心、嘔吐為其主要臨床錶現.2例患者CA19-9及CA24-2明顯升高.CT、MRI及DSA為主要影像學診斷手段,但術前無1例診斷為胰腺腺泡細胞癌,均為術後病理證實.手術切除率相對較高,但手術時間長、術中齣血量大及可能聯閤多器官切除.術後平均隨訪60箇月,平均生存期為(32±8)箇月.結論 胰腺腺泡細胞癌的臨床特點及生物學行為有彆于導管腺癌,其一些相對特殊的臨床錶現及影像學改變有助于術前定性診斷.該疾病手術切除率高,預後較好,治療應持積極態度.
목적 분석총결이선선포세포암림상특점,탐토기진단방법급외과치료책략.방법 총결2002년1월지2012년1월접수수술치료적이선선포세포암환자적림상자료,대기림상표현、진단、치료、예후진행분석.결과 공수집도구유완정병례자료적이선선포세포암환자6례,기중남성3례,녀성3례；년령30～ 63세,평균년령47.8세.6례환자중,복통、소수、배통、악심、구토위기주요림상표현.2례환자CA19-9급CA24-2명현승고.CT、MRI급DSA위주요영상학진단수단,단술전무1례진단위이선선포세포암,균위술후병리증실.수술절제솔상대교고,단수술시간장、술중출혈량대급가능연합다기관절제.술후평균수방60개월,평균생존기위(32±8)개월.결론 이선선포세포암적림상특점급생물학행위유별우도관선암,기일사상대특수적림상표현급영상학개변유조우술전정성진단.해질병수술절제솔고,예후교호,치료응지적겁태도.
Objective To investigate the clinical features,diagnostic and therapeutic strategy of pancreatic acinar cell carcinoma.Methods The data of pancreatic acinar cell carcinoma patients who underwent surgical operations from January 2002 to January 2012 were retrospectively reviewed.Results Six cases of pancreatic acinar cell carcinoma,identified with pathology were collected,including 3 males and 3 females with the average of 47.8 yeas old.Upper abdominal pain was present in 5 cases,weight loss was present in 4 cases with the average of 12.5 kg.Other symptoms included nausea/vomiting,back pain and obstructive jaundice.The serum CA19-9 and CA24-2 level were significantly elevated in 2 cases.CT scan,MRI and DSA were the main imaging methods to diagnose this disease.However,no case was diagnosed as pancreatic acinar cell carcinoma before operation.All cases were confirmed by the pathological examination.Relatively high rates of surgical resection,long operative time,more blood loss and combined multi-organ resection were the characteristics of this disease's operative surgical procedures.The average period of postoperative follow-up process was 60 months,and the mean survival time was (32 ± 8) months.Conclusions The clinical features and biological behavior of pancreatic acinar cell carcinoma are different from those of ductal adenocarcinoma,while the relatively specific clinical manifestations and imaging changes will be helpful for qualitative diagnosis before operation.As it has high rate of resection and better prognosis,more radical surgical strategies should be carried out for patients of this disease.
