中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2013年
5期
421-425
,共5页
汤志伟%石祥恩%常永凯%王震
湯誌偉%石祥恩%常永凱%王震
탕지위%석상은%상영개%왕진
动脉粥样硬化%颈动脉狭窄%衣原体,肺炎%脑血管意外
動脈粥樣硬化%頸動脈狹窄%衣原體,肺炎%腦血管意外
동맥죽양경화%경동맥협착%의원체,폐염%뇌혈관의외
Atherosclerosis%Carotid stenosis%Chlamydophila pneumonia%Cerebrovascular accident
目的 研究肺炎衣原体感染与颈动脉粥样硬化的关系,并探讨肺炎衣原体感染与脑血管缺血事件的相关性.方法 收集2010年1月至2011年12月行单侧颈动脉内膜剥脱术治疗颈动脉狭窄的19例患者的粥样硬化斑块组织(实验组),取同期行颅内外血管搭桥患者的修剪血管组织为正常对照(对照组),共10例.两组资料具有可比性.采用免疫组化方法,检测所有组织肺炎衣原体的感染情况,以及Toll样受体2(TLR2)、肿瘤坏死因子-α(TNF-α)和血管细胞黏附分子-1(VCAM-1)的表达情况,结果采用Fisher确切概率法进行统计分析.结果 实验组动脉粥样硬化斑块中肺炎衣原体阳性率为9/19,对照组中无肺炎衣原体阳性发现,差异有统计学差异(P=0.011).实验组中有脑缺血事件患者15例,肺炎衣原体阳性率为9/15;无脑缺血事件患者4例无肺炎衣原体阳性发现,但差异无统计学差异(P=0.087).肺炎衣原体、TLR2、TNF-α和VCAM-1在颈动脉粥样硬化同一区域呈阳性表达.结论 肺炎衣原体感染与颈动脉粥样硬化密切相关,肺炎衣原体感染与脑血管缺血事件发生可能具有相关性.
目的 研究肺炎衣原體感染與頸動脈粥樣硬化的關繫,併探討肺炎衣原體感染與腦血管缺血事件的相關性.方法 收集2010年1月至2011年12月行單側頸動脈內膜剝脫術治療頸動脈狹窄的19例患者的粥樣硬化斑塊組織(實驗組),取同期行顱內外血管搭橋患者的脩剪血管組織為正常對照(對照組),共10例.兩組資料具有可比性.採用免疫組化方法,檢測所有組織肺炎衣原體的感染情況,以及Toll樣受體2(TLR2)、腫瘤壞死因子-α(TNF-α)和血管細胞黏附分子-1(VCAM-1)的錶達情況,結果採用Fisher確切概率法進行統計分析.結果 實驗組動脈粥樣硬化斑塊中肺炎衣原體暘性率為9/19,對照組中無肺炎衣原體暘性髮現,差異有統計學差異(P=0.011).實驗組中有腦缺血事件患者15例,肺炎衣原體暘性率為9/15;無腦缺血事件患者4例無肺炎衣原體暘性髮現,但差異無統計學差異(P=0.087).肺炎衣原體、TLR2、TNF-α和VCAM-1在頸動脈粥樣硬化同一區域呈暘性錶達.結論 肺炎衣原體感染與頸動脈粥樣硬化密切相關,肺炎衣原體感染與腦血管缺血事件髮生可能具有相關性.
목적 연구폐염의원체감염여경동맥죽양경화적관계,병탐토폐염의원체감염여뇌혈관결혈사건적상관성.방법 수집2010년1월지2011년12월행단측경동맥내막박탈술치료경동맥협착적19례환자적죽양경화반괴조직(실험조),취동기행로내외혈관탑교환자적수전혈관조직위정상대조(대조조),공10례.량조자료구유가비성.채용면역조화방법,검측소유조직폐염의원체적감염정황,이급Toll양수체2(TLR2)、종류배사인자-α(TNF-α)화혈관세포점부분자-1(VCAM-1)적표체정황,결과채용Fisher학절개솔법진행통계분석.결과 실험조동맥죽양경화반괴중폐염의원체양성솔위9/19,대조조중무폐염의원체양성발현,차이유통계학차이(P=0.011).실험조중유뇌결혈사건환자15례,폐염의원체양성솔위9/15;무뇌결혈사건환자4례무폐염의원체양성발현,단차이무통계학차이(P=0.087).폐염의원체、TLR2、TNF-α화VCAM-1재경동맥죽양경화동일구역정양성표체.결론 폐염의원체감염여경동맥죽양경화밀절상관,폐염의원체감염여뇌혈관결혈사건발생가능구유상관성.
Objectives To study the correlation between Chlamydiae Pneumonia and carotid atherosclerosis,and the correlation between the infection of Chlamydiae Pneumonia and ischemic events.Methods The study group consisted of 19 patients who underwent unilateral carotid endarterectomy surgery during the period from January 2010 to December 2011,and the atherosclerotic plaque specimens were harvested from these patients.The control group consisted of 10 patients who underwent extracranialintracranial bypass surgery during the same period,and the normal external carotid artery specimens were got from these patients.The clinical data between the two groups had comparability.The presence of Chlamydiae Pneumonia in atherosclerotic plaque and normal artery tissue were investigated by immunohistochemistry.The expression of Toll-like receptor 2 (TLR2),tumor necrosis factor-α (TNF-α) and vascular cell adhesion molecule-1 (VCAM-1) in the atherosclerotic plaque infected with Chlamydiae Pneumonia were also detected.Data were analyzed using Fisher's exact test.Results Chlamydiae Pneumonia was found in 9 of 19 atherosclerotic plaques,while no positive result was found in control group.The statistical analysis showed a significant difference(P =0.011).Among the 19 patients in study group,15 of them had ischemic events,and Chlamydiae Pneumonia was found in 9 of these 15 patients ; while the other 4 patients didn't have any ischemic events and no Chlamydiae Pneumonia was found in them,but there was no statistical different between them (P =0.087).Through immunohistochemistry,the expression of Chlamydiae Pneumonia,TLR2,TNF-α and VCAM-1 were found in same area.Conclusions There is a correlation between Chlamydiae Pneumonia and carotid atherosclerosis.And there might be a correlation between Chlamydiae Pneumonia and cerebral ischemic events.