中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2013年
10期
904-907
,共4页
叶波%冯键%潘旭峰%杨煜%耿俊峰%曹克坚%赵珩%胡定中
葉波%馮鍵%潘旭峰%楊煜%耿俊峰%曹剋堅%趙珩%鬍定中
협파%풍건%반욱봉%양욱%경준봉%조극견%조형%호정중
肺肿瘤%腺癌%淋巴转移%淋巴结切除术%诊断,计算机辅助
肺腫瘤%腺癌%淋巴轉移%淋巴結切除術%診斷,計算機輔助
폐종류%선암%림파전이%림파결절제술%진단,계산궤보조
Lung neoplasms%Adenocarcinoma%Lymphatic metastasis%Lymph node excision%Diagnosis,computer-assisted
目的 分析T1a期肺腺癌患者的临床资料,确定与淋巴结转移相关的临床因素.方法 回顾性分析2012年1-6月217例表现为外周型小结节直径<2 cm的T1a肺腺癌患者资料,其中男性105例,女性112例;年龄32 ~ 85岁,平均(61±11)岁.记录淋巴结转移相关的临床因素,包括年龄、性别、吸烟史、症状、肿瘤大小、影像学表现、胸膜受侵、空气支气管征、癌胚抗原、手术方式、病理分型及淋巴结转移情况,部分患者曾行PET-CT者则记录最大标准摄取值(SUVmax).通过单因素及多因素分析,寻找容易发生淋巴结转移的临床相关因素.结果 表现为纯磨玻璃影的35例患者中,有11例为不典型腺瘤样增生,有24例为原位腺癌,无一例发生淋巴结转移;表现为混合型磨玻璃影的89例患者中84例(94.4%)无淋巴结转移,只有5例(6.0%)患者发生淋巴结转移;而表现为实性结节的93例患者中共有28例(30.1%)发生淋巴结转移;三者间淋巴结转移差异具有统计学意义(x2=23.41,P<0.001).单因素分析发现,肿瘤直径>1 cm(x2 =9.021,P<0.003)、影像学表现为混合性结节或实性结节(x2 =23.41,P<0.000)、癌胚抗原>5 μg/L(x2 =15.541,P<0.000)及SUVmax>5(x2=0.644,P<0.000)是影响肺腺癌淋巴结转移的相关因素.多因素分析显示影像学表现为混合性结节或实性结节是淋巴结转移的独立相关临床因素(OR=166.116,95% CI:18.161~25.19,P<0.001).结论 高分辨CT表现为纯毛玻璃影的患者一般没有淋巴结转移,肿瘤直径>1 cm、影像学表现为混合性结节或实性结节、癌胚抗原>5 μg/L、SUVmax>5的肺腺癌患者更易发生淋巴结转移;其中影像学表现为混合性结节或实性结节是淋巴结转移的独立相关临床因素.
目的 分析T1a期肺腺癌患者的臨床資料,確定與淋巴結轉移相關的臨床因素.方法 迴顧性分析2012年1-6月217例錶現為外週型小結節直徑<2 cm的T1a肺腺癌患者資料,其中男性105例,女性112例;年齡32 ~ 85歲,平均(61±11)歲.記錄淋巴結轉移相關的臨床因素,包括年齡、性彆、吸煙史、癥狀、腫瘤大小、影像學錶現、胸膜受侵、空氣支氣管徵、癌胚抗原、手術方式、病理分型及淋巴結轉移情況,部分患者曾行PET-CT者則記錄最大標準攝取值(SUVmax).通過單因素及多因素分析,尋找容易髮生淋巴結轉移的臨床相關因素.結果 錶現為純磨玻璃影的35例患者中,有11例為不典型腺瘤樣增生,有24例為原位腺癌,無一例髮生淋巴結轉移;錶現為混閤型磨玻璃影的89例患者中84例(94.4%)無淋巴結轉移,隻有5例(6.0%)患者髮生淋巴結轉移;而錶現為實性結節的93例患者中共有28例(30.1%)髮生淋巴結轉移;三者間淋巴結轉移差異具有統計學意義(x2=23.41,P<0.001).單因素分析髮現,腫瘤直徑>1 cm(x2 =9.021,P<0.003)、影像學錶現為混閤性結節或實性結節(x2 =23.41,P<0.000)、癌胚抗原>5 μg/L(x2 =15.541,P<0.000)及SUVmax>5(x2=0.644,P<0.000)是影響肺腺癌淋巴結轉移的相關因素.多因素分析顯示影像學錶現為混閤性結節或實性結節是淋巴結轉移的獨立相關臨床因素(OR=166.116,95% CI:18.161~25.19,P<0.001).結論 高分辨CT錶現為純毛玻璃影的患者一般沒有淋巴結轉移,腫瘤直徑>1 cm、影像學錶現為混閤性結節或實性結節、癌胚抗原>5 μg/L、SUVmax>5的肺腺癌患者更易髮生淋巴結轉移;其中影像學錶現為混閤性結節或實性結節是淋巴結轉移的獨立相關臨床因素.
목적 분석T1a기폐선암환자적림상자료,학정여림파결전이상관적림상인소.방법 회고성분석2012년1-6월217례표현위외주형소결절직경<2 cm적T1a폐선암환자자료,기중남성105례,녀성112례;년령32 ~ 85세,평균(61±11)세.기록림파결전이상관적림상인소,포괄년령、성별、흡연사、증상、종류대소、영상학표현、흉막수침、공기지기관정、암배항원、수술방식、병리분형급림파결전이정황,부분환자증행PET-CT자칙기록최대표준섭취치(SUVmax).통과단인소급다인소분석,심조용역발생림파결전이적림상상관인소.결과 표현위순마파리영적35례환자중,유11례위불전형선류양증생,유24례위원위선암,무일례발생림파결전이;표현위혼합형마파리영적89례환자중84례(94.4%)무림파결전이,지유5례(6.0%)환자발생림파결전이;이표현위실성결절적93례환자중공유28례(30.1%)발생림파결전이;삼자간림파결전이차이구유통계학의의(x2=23.41,P<0.001).단인소분석발현,종류직경>1 cm(x2 =9.021,P<0.003)、영상학표현위혼합성결절혹실성결절(x2 =23.41,P<0.000)、암배항원>5 μg/L(x2 =15.541,P<0.000)급SUVmax>5(x2=0.644,P<0.000)시영향폐선암림파결전이적상관인소.다인소분석현시영상학표현위혼합성결절혹실성결절시림파결전이적독립상관림상인소(OR=166.116,95% CI:18.161~25.19,P<0.001).결론 고분변CT표현위순모파리영적환자일반몰유림파결전이,종류직경>1 cm、영상학표현위혼합성결절혹실성결절、암배항원>5 μg/L、SUVmax>5적폐선암환자경역발생림파결전이;기중영상학표현위혼합성결절혹실성결절시림파결전이적독립상관림상인소.
Objective To analyze the data of patients with clinical stage T1a lung adenocarcinoma and find the predictive factors associated with lymph node metastasis.Methods From January to June 2012,271 patients with small nodules of peripheral lung adenocarcinoma were enrolled in the retrospective review.There were 105 male and 112 female patients,with an average age of (61 ± 11) years (range 32-85 years).The data were collected including age,gender,smoking history,carcinoembryonic antigen (CEA),imaging findings,surgical procedure,pleural involvement,symptoms,tumor size,pathological classification,pathologic stage,maximum standardized uptake value(SUVmax) and lymph node metastasis.The predictive factors of lymph node metastasis in clinical factors were detected by univariate and multivariate analysis.Results By preoperative thin-section CT,35 patients were categorized as pure ground-grass opacity(GGO),11 cases of atypical adenomatous hyperplasia,24 cases of adenocarcinoma in situ,with no lymph node metastasis.Categorized as mixed ground-glass opacities in 89 patients,84 patients (94.4%) had no lymph node metastasis,only 5 patients (6.0%) with lymph node metastasis.Categorized as solid nodules in 93 patients,a total of 28 cases (30.1%) had lymph node metastasis.There were statistically significant difference between three groups(x2 =23.41,P < 0.001).By univariate analysis,we found that the predictive factors of lymph node metastasis were as follows:tumor size > 1 cm(x2 =9.021,P <0.003),imaging performance with mixed GGO or solid nodules (x2 =23.41,P < 0.000),CEA >5 μg/L (x2 =15.541,P < 0.000) and PET-CT SUVmax > 5 (x2 =0.644,P < 0.000).By multivariate analysis,we found that imaging performance(mixed GGO or solid nodules) was the independent predictor of lymph node metastasis in clinical factors (OR =166.116,95 % CI:18.161-25.19,P < 0.001).Conclusions Patients of pure GGO generally do not have lymph node metastasis.Tumor diameter > 1 cm,imaging findings with the mixed GGO or solid nodules,carcinoembryonic antigen CEA > 5 μg/L,PET-CT SUVmax > 5 are predictive factors of lymph node metastasis in which imaging is independent predictor.