CAJ | 학술논문

目的评价窄带光成像(NBI)技术结合膀胱镜(简称NBI膀胱镜)诊断膀胱癌的价值.方法通过检索PubMed、Cochrane Library、EMbase、中国知网等数据库有关NBI膀胱镜诊断膀胱癌的临床对照研究文献,严格根据纳入及排除标准筛选文献,对符合纳入标准文献采用MetaDiSc 1.4软件进行meta分析.结果共8篇文献被纳入,受试患者共1 022例(1 086处病灶).NBI膀胱镜和白光膀胱镜检测膀胱癌总灵敏度分别为0.943(95％CI:0.914～0.964)、0.848(95％CI:0.803 ～0.885),特异度分别为0.847(95％CI:0.812 ～0.878)、0.870(95％CI:0.831 ～0.903),阳性似然比分别为7.038(95％ CI:3.357 ～ 14.754)、6.938(95％ CI:2.052 ～ 23.465),阴性似然比分别为0.054(95％ CI:0.012 ～0.237)、0.181 (95％ CI:0.091 ～0.361),诊断优势比分别为185.32(95％CI:45.714 ～ 751.260)、42.931 (95％ CI:8.088 ～ 227.880),曲线下面积分别为0.978、0.894,Q*指数值分别为0.934、0.825.结论 NBI膀胱镜诊断膀胱癌的效能明显优于白光膀胱镜,值得临床推广.
목적 평개착대광성상(NBI)기술결합방광경(간칭NBI방광경)진단방광암적개치.방법 통과검색PubMed、Cochrane Library、EMbase、중국지망등수거고유관NBI방광경진단방광암적림상대조연구문헌,엄격근거납입급배제표준사선문헌,대부합납입표준문헌채용MetaDiSc 1.4연건진행meta분석.결과 공8편문헌피납입,수시환자공1 022례(1 086처병조).NBI방광경화백광방광경검측방광암총령민도분별위0.943(95％CI:0.914～0.964)、0.848(95％CI:0.803 ～0.885),특이도분별위0.847(95％CI:0.812 ～0.878)、0.870(95％CI:0.831 ～0.903),양성사연비분별위7.038(95％ CI:3.357 ～ 14.754)、6.938(95％ CI:2.052 ～ 23.465),음성사연비분별위0.054(95％ CI:0.012 ～0.237)、0.181 (95％ CI:0.091 ～0.361),진단우세비분별위185.32(95％CI:45.714 ～ 751.260)、42.931 (95％ CI:8.088 ～ 227.880),곡선하면적분별위0.978、0.894,Q*지수치분별위0.934、0.825.결론 NBI방광경진단방광암적효능명현우우백광방광경,치득림상추엄.
Objectives To evaluate the value of narrow band imaging (NBI) cystoscopy in detection of bladder cancer.Methods Literatures on narrow-band imaging cystoscopy in diagnosis of bladder cancer,controlled clinical research was searched in PubMed,Cochrane Library,EMbase,and the Chinese Biomedical Literature Database.The literatures were selected according to the inclusion and exclusion criteria.The Meta-DiSc 1.4 software was used to review management and analysis.Results The 8 studies met the inclusion criteria.On a per-people analysis,the pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic odds ratio (DOR) of NBI cystoscopy and white light imaging (WLI) cystoscopy were respectively 0.943 (95 ％ CI:0.914-0.964) and 0.848 (95 ％ CI:0.803-0.885),0.847 (95％CI:0.812-0.878) and 0.870 (95％ CI:0.831-0.903),7.038 (95％ CI:3.357-14.754) and 6.938 (95％CI:2.052-23.465),0.054 (95％ C I:0.012-0.237) and 0.181 (95％CI:0.091-0.361),185.32 (95％ CI:45.714-751.260) and 42.931 (95％ CI:8.088-227.880).The areas under the curve (AUC) and Q * of NBI cystoscopy and WLI cystoscopy were 0.978 and 0.894,0.934 and 0.825 respectively.Conclusion NBI cystoscopy is accurate with high diagnostic precision for diagnosis of bladder cancer.NBI cystoscopy is prior to WLI cystoscopy,but it needs more clinical evidence for further affirmance.