CAJ | 학술논문

目的探讨腋窝淋巴结阳性原发性乳腺癌循环肿瘤细胞(CTC)与空芯针穿刺原发肿瘤临床病理特征之间的相关性.方法采集126例腋窝淋巴结阳性原发性乳腺癌患者的外周静脉血,使用CellSeareh系统检测外周血CTC,分析CTC与原发肿瘤临床病理特征之间的相关性.患者均为女性,年龄27～ 65岁,中位年龄49岁.结果 126例患者中,32例可检测出CTC,阳性率为25.4％(32/126),其中人类表皮生长因子受体2(HER-2)阳性患者CTC阳性率为36.2％ (17/47),HER-2阴性患者CTC阳性率为19.0％(15/79),两者差异有统计学意义(x2=4.592,P＜0.05).多因素回归分析显示,HER-2阳性患者外周血检出CTC的风险是HER-2阴性患者的2.712倍(OR=2.712,95％ CI:1.117 ～6.584,P=0.027),而年龄、月经状态、肿瘤T分期、病理类型、组织学分级、激素受体状态及Ki-67表达水平不同的患者之间,CTC阳性率的差异并无统计学意义(P＞0.05).结论腋窝淋巴结阳性原发性乳腺癌CTC与原发肿瘤HER-2状态相关,而与患者年龄、月经状态、肿瘤T分期、病理类型、组织学分级、激素受体状态及Ki-67表达水平无明显相关性.
목적 탐토액와림파결양성원발성유선암순배종류세포(CTC)여공심침천자원발종류림상병리특정지간적상관성.방법 채집126례액와림파결양성원발성유선암환자적외주정맥혈,사용CellSeareh계통검측외주혈CTC,분석CTC여원발종류림상병리특정지간적상관성.환자균위녀성,년령27～ 65세,중위년령49세.결과 126례환자중,32례가검측출CTC,양성솔위25.4％(32/126),기중인류표피생장인자수체2(HER-2)양성환자CTC양성솔위36.2％ (17/47),HER-2음성환자CTC양성솔위19.0％(15/79),량자차이유통계학의의(x2=4.592,P＜0.05).다인소회귀분석현시,HER-2양성환자외주혈검출CTC적풍험시HER-2음성환자적2.712배(OR=2.712,95％ CI:1.117 ～6.584,P=0.027),이년령、월경상태、종류T분기、병리류형、조직학분급、격소수체상태급Ki-67표체수평불동적환자지간,CTC양성솔적차이병무통계학의의(P＞0.05).결론 액와림파결양성원발성유선암CTC여원발종류HER-2상태상관,이여환자년령、월경상태、종류T분기、병리류형、조직학분급、격소수체상태급Ki-67표체수평무명현상관성.
Objective To investigate the correlations between circulating tumor cell (CTC) and clinicopathologic characteristics of tumors obtained by core needle biopsy in axillary lymph node positive primary breast cancer patients.Methods The peripheral venous blood samples were collected from 126 patients with axillary lymph node positive primary breast cancer and were detected to found CTCs using the CellSearch automatic detection system.The associations between CTCs and clinicopathologic characteristics of tumors were analyzed in axillary lymph node positive primary breast cancer patients.All patients were female,age ranging from 27 to 65 years (median,49 years).Results One or more CTCs were detected from the peripheral blood in 25.4％ (32/126) patients.The positive rate of CTCs was 36.2％ (17/47) in the human epidermal growth factor receptor 2 (HER-2) (+) patients,19.0％ (15/79) in the HER-2 (-) patients.In univariate analysis,there were significant differences about the positive rate of CTCs between the two groups (x2 =4.592,P ＜ 0.05).In multivariate analysis,the risk of circulating tumor cells positive in HER-2 (+) patients was 2.712 times higher than in HER-2 (-) patients(OR =2.712,95％ CI:1.117-6.584,P =0.027),whereas the positive rate of CTCs in axillary lymph node positive primary breast cancer patients showed no significant differences among the different subgroups with regards to age,menopausal status,the T staging of the tumor,histological type,histological grade,hormone receptor status and Ki-67 expression level (P ＞ 0.05).Conclusions There are significant correlations between the presence of CTCs and the HER-2 status of the tumor in axillary lymph node positive primary breast cancer patients.No significant correlations are found between the presence of CTCs and the age,menopausal status,T staging of the tumor,histological type,histological grade,hormone receptor status and Ki-67 expression level.