中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2014年
7期
529-532
,共4页
齐浩山%张福先%刘勇%闫凤采%龙妍妤%梁刚柱%高志敏%李大林%张鲲
齊浩山%張福先%劉勇%閆鳳採%龍妍妤%樑剛柱%高誌敏%李大林%張鯤
제호산%장복선%류용%염봉채%룡연여%량강주%고지민%리대림%장곤
静脉血栓形成%肺栓塞%早日下床活动%卧床休息%股静脉%兔
靜脈血栓形成%肺栓塞%早日下床活動%臥床休息%股靜脈%兔
정맥혈전형성%폐전새%조일하상활동%와상휴식%고정맥%토
Venous thrombosis%Pulmonary embolism%Early ambulation%Bed rest%Femoral vein%Rabbits
目的 探索在下肢深静脉血栓形成后的不同时期活动对肺栓塞的影响.方法 48只新西兰白兔随机分为早期、中期、晚期组,每组再分为制动组、活动组.下肢深静脉血栓造模后,早期组中制动组制动3d,活动组活动3d,随后处死取肺行病理检查;中期组中制动组制动7d,活动组先制动3d再活动4d后处死;晚期组中制动组制动14 d,活动组先制动7d再活动7d后处死.统计分析各组肺栓塞的情况.结果 早期组中制动组和活动组肺栓塞发生率分别为4/8、3/8,肺叶栓塞发生率为17.5％ (7/40)、15.0％ (6/40);中期组中制动组和活动组肺栓塞发生率分别为3/8、2/8,肺叶栓塞发生率为12.5％ (5/40)、10.0％(4/40);晚期组中制动组和活动组肺栓塞发生率分别为3/8、3/8,肺叶栓塞发生率为12.5％ (5/40)、15.0％ (6/40).在血栓形成后的不同时期,制动组和活动组肺栓塞、肺叶栓塞发生率差异均无统计学意义(P＞0.05).结论 兔急性下肢深静脉血栓形成后,在抗凝治疗的前提下,早期活动并不增加肺栓塞发生的风险.
目的 探索在下肢深靜脈血栓形成後的不同時期活動對肺栓塞的影響.方法 48隻新西蘭白兔隨機分為早期、中期、晚期組,每組再分為製動組、活動組.下肢深靜脈血栓造模後,早期組中製動組製動3d,活動組活動3d,隨後處死取肺行病理檢查;中期組中製動組製動7d,活動組先製動3d再活動4d後處死;晚期組中製動組製動14 d,活動組先製動7d再活動7d後處死.統計分析各組肺栓塞的情況.結果 早期組中製動組和活動組肺栓塞髮生率分彆為4/8、3/8,肺葉栓塞髮生率為17.5％ (7/40)、15.0％ (6/40);中期組中製動組和活動組肺栓塞髮生率分彆為3/8、2/8,肺葉栓塞髮生率為12.5％ (5/40)、10.0％(4/40);晚期組中製動組和活動組肺栓塞髮生率分彆為3/8、3/8,肺葉栓塞髮生率為12.5％ (5/40)、15.0％ (6/40).在血栓形成後的不同時期,製動組和活動組肺栓塞、肺葉栓塞髮生率差異均無統計學意義(P＞0.05).結論 兔急性下肢深靜脈血栓形成後,在抗凝治療的前提下,早期活動併不增加肺栓塞髮生的風險.
목적 탐색재하지심정맥혈전형성후적불동시기활동대폐전새적영향.방법 48지신서란백토수궤분위조기、중기、만기조,매조재분위제동조、활동조.하지심정맥혈전조모후,조기조중제동조제동3d,활동조활동3d,수후처사취폐행병리검사;중기조중제동조제동7d,활동조선제동3d재활동4d후처사;만기조중제동조제동14 d,활동조선제동7d재활동7d후처사.통계분석각조폐전새적정황.결과 조기조중제동조화활동조폐전새발생솔분별위4/8、3/8,폐협전새발생솔위17.5％ (7/40)、15.0％ (6/40);중기조중제동조화활동조폐전새발생솔분별위3/8、2/8,폐협전새발생솔위12.5％ (5/40)、10.0％(4/40);만기조중제동조화활동조폐전새발생솔분별위3/8、3/8,폐협전새발생솔위12.5％ (5/40)、15.0％ (6/40).재혈전형성후적불동시기,제동조화활동조폐전새、폐협전새발생솔차이균무통계학의의(P＞0.05).결론 토급성하지심정맥혈전형성후,재항응치료적전제하,조기활동병불증가폐전새발생적풍험.
Objective To evaluate the corresponding influence on pulmonary embolism incidence between immobilization and exercise in different stage of thrombus after acute deep vein thrombosis in rabbits.Methods Forty-eight New Zealand rabbits were randomly divided into three groups depending on the different organized stage of thrombus:the early,medium and later stage group.Each group was subdivided into two sub groups:the immobile and mobile subgroup.Rabbit modeling of deep vein thrombosis was made by ligating the right femoral vein.Among the early-stage group,rabbits of the immobile subgroup were fixed for 3 days,while that of the mobile subgroup were free to move for 3 days,then each was euthanized to extract the lungs for pathological examination.Among the medium-stage group,each of the immobile subgroup were fixed for 7 days,while the mobile subgroup ones were fixed for 3 days,then released free-moving for 4 days following the pathological extraction.Among the later-stage group,animals in the immobile subgroup were fixed for 14 days comparing the mobile subgroup fixed for 7 days and next freemoving for 7 days,then each was euthanized.Results Among the early-stage group,pulmonary embolismincidence (PEI) of the immobile and mobile subgroup was 4/8 vs.3/8,the pulmonary lobe embolism incidence (PLEI) was 17.5％ (7/40) vs.15.0％ (6/40).Among the medium-stage group,PEI of the immobile and mobile subgroup was 3/8 vs.2/8,PLEI was 37.5％ (7/40) vs.25.0％ (10/40).Among the later-stage group,PEI of the immobile and mobile subgroup was 3/8 vs.3/8,PLEI was 12.5％ (5/40) vs.15.0％ (6/40).There was no statistical difference between immobilization subgroup and mobilization subgroup among different stage group.Conclusion On the premise of given anticoagulation treatment,early ambulation do not significantly increase pulmonary embolism incidence after acute deep vein thrombosis of lower extremity in rabbits.
