CAJ | 학술논문

目的应用荟萃分析探求并评估啮齿类动物肾脏缺血再灌注模型中两性肾损伤差异.方法检索PubMed与EMBASE数据库从2002年1月至2014年1月的相关文献,并阅读引入文献的参考文献以弥补缺漏.制定文献纳入及排除标准,并通过查阅文献制定效应指标的评价标准.采用Stata 12.0软件进行数据处理.结果纳入14篇文献,共采用了289只动物.啮齿类动物在遭受肾脏缺血再灌注损伤后,雌性肾脏损伤程度在血肌酐[SMD=-5.95(-7.39,-4.51),P＜0.01]、尿素氮[SMD=-3.76(-5.60,-1.93),P＜0.01]均低于雄性.亚组分析显示,啮齿动物种类、肾脏缺血时间都会显著影响两性间肾脏损伤差异的大小;其中,缺血时间达45 min时,两性间差异达到最大.结论啮齿动物在肾缺血再灌注后两性肾损伤程度存有差异,且缺血时间、动物种类会影响这种差异的程度.通过调整缺血时间可能会使两性损伤差异最大化.纳入的试验异质性较大且存在发表偏倚,尚需设计严谨实验.
목적 응용회췌분석탐구병평고교치류동물신장결혈재관주모형중량성신손상차이.방법 검색PubMed여EMBASE수거고종2002년1월지2014년1월적상관문헌,병열독인입문헌적삼고문헌이미보결루.제정문헌납입급배제표준,병통과사열문헌제정효응지표적평개표준.채용Stata 12.0연건진행수거처리.결과 납입14편문헌,공채용료289지동물.교치류동물재조수신장결혈재관주손상후,자성신장손상정도재혈기항[SMD=-5.95(-7.39,-4.51),P＜0.01]、뇨소담[SMD=-3.76(-5.60,-1.93),P＜0.01]균저우웅성.아조분석현시,교치동물충류、신장결혈시간도회현저영향량성간신장손상차이적대소;기중,결혈시간체45 min시,량성간차이체도최대.결론 교치동물재신결혈재관주후량성신손상정도존유차이,차결혈시간、동물충류회영향저충차이적정도.통과조정결혈시간가능회사량성손상차이최대화.납입적시험이질성교대차존재발표편의,상수설계엄근실험.
Objective To evaluate the gender difference in renal ischemia/reperfusion injury in rodents conducting a meta-analysis.Methods Related literatures were searched from PubMed and Embase from 2002 to 2014.Including and excluding cretria were formulated.The articles were evaluated.Stata 12.0 was used to analyzed the data.Results 14 articles were included,with 289 animals.After renal ischemia/ reperfusion injury,Scr (SMD=-5.95 [-7.39,-4.51,P ＜ 0.01]),BUN (SMD=-3.76 [-5.60,-1.93],P ＜ 0.01),and pathological score (SMD=-3.32 [-4.65,-1.99]) were lower in the female than in the male rodents.Subgroup analysis indicated that species and ischemia time affected the difference; when ischemia time reached 45 min,the gender difference widened to its peak.Conclusions There is difference in renal injury between male and female rodents after renal ischemia/reperfusion.The difference could be affected by isckemia itme and animal species and could be reached to its peak adjusting ischemia time.Meanwhile,some clinical research can benefit from our findings.