中华物理医学与康复杂志
中華物理醫學與康複雜誌
중화물리의학여강복잡지
CHINESE JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
2011年
11期
851-855
,共5页
李晓裔%邵西仓%陈戈雨%桂湘芗
李曉裔%邵西倉%陳戈雨%桂湘薌
리효예%소서창%진과우%계상향
多奈哌齐%轻度认知功能障碍%神经心理学检测%听觉事件相关电位
多奈哌齊%輕度認知功能障礙%神經心理學檢測%聽覺事件相關電位
다내고제%경도인지공능장애%신경심이학검측%은각사건상관전위
Donepezil%Mild cognitive impairment%Neuropsychological tests%Auditory event-related potentials
目的 探讨多奈哌齐对轻度认知功能障碍(MCI)患者听觉事件相关电位的影响.方法 对轻度认知功能障碍患者34例进行听觉事件相关电位检测,同时进行神经心理学测试.患者入组时给予口服多奈哌齐5 mg,每日1次,治疗3个月后行神经心理学测试并复查听觉事件相关电位.结果 治疗后,MCI患者神经心理各项评分较治疗前均显著改善,差异有统计学意义(P＜0.01)；但Boston命名测验得分较治疗前无显著改善,差异无统计学意义(P＞0.05).治疗后,MCI患者PS0波幅较治疗前降低,差异有统计学意义(P＜0.05)；P300波幅较治疗前升高,潜伏期缩短,差异有统计学意义(P＜0.05).治疗前,MCI患者PS0波幅与P300潜伏期呈正相关,且P50波幅和P300潜伏期与认知试验记忆功能各项评分均呈负相关.结论 多奈哌齐可改善MCI患者的认知功能,尤其是记忆功能.听觉事件相关电位的PS0和P300可作为观察MCI的指标,同时也可作为评估多奈哌齐治疗MCI疗效的指标.
目的 探討多奈哌齊對輕度認知功能障礙(MCI)患者聽覺事件相關電位的影響.方法 對輕度認知功能障礙患者34例進行聽覺事件相關電位檢測,同時進行神經心理學測試.患者入組時給予口服多奈哌齊5 mg,每日1次,治療3箇月後行神經心理學測試併複查聽覺事件相關電位.結果 治療後,MCI患者神經心理各項評分較治療前均顯著改善,差異有統計學意義(P＜0.01)；但Boston命名測驗得分較治療前無顯著改善,差異無統計學意義(P＞0.05).治療後,MCI患者PS0波幅較治療前降低,差異有統計學意義(P＜0.05)；P300波幅較治療前升高,潛伏期縮短,差異有統計學意義(P＜0.05).治療前,MCI患者PS0波幅與P300潛伏期呈正相關,且P50波幅和P300潛伏期與認知試驗記憶功能各項評分均呈負相關.結論 多奈哌齊可改善MCI患者的認知功能,尤其是記憶功能.聽覺事件相關電位的PS0和P300可作為觀察MCI的指標,同時也可作為評估多奈哌齊治療MCI療效的指標.
목적 탐토다내고제대경도인지공능장애(MCI)환자은각사건상관전위적영향.방법 대경도인지공능장애환자34례진행은각사건상관전위검측,동시진행신경심이학측시.환자입조시급여구복다내고제5 mg,매일1차,치료3개월후행신경심이학측시병복사은각사건상관전위.결과 치료후,MCI환자신경심리각항평분교치료전균현저개선,차이유통계학의의(P＜0.01)；단Boston명명측험득분교치료전무현저개선,차이무통계학의의(P＞0.05).치료후,MCI환자PS0파폭교치료전강저,차이유통계학의의(P＜0.05)；P300파폭교치료전승고,잠복기축단,차이유통계학의의(P＜0.05).치료전,MCI환자PS0파폭여P300잠복기정정상관,차P50파폭화P300잠복기여인지시험기억공능각항평분균정부상관.결론 다내고제가개선MCI환자적인지공능,우기시기억공능.은각사건상관전위적PS0화P300가작위관찰MCI적지표,동시야가작위평고다내고제치료MCI료효적지표.
Objective To explore the effects of donepezil on auditory event-related potentials in cases of mild cognitive impairment(MCI).Methods Thirty-four mildly impaired patients were examined using auditory event-related potentials and neuropsychological tests.All patients received 5 mg of donepezil orally each day.The patients were retested with the neuropsychological scales and re-examined for auditory event-related potentials after 3 months of treatment.Results All neuropsychological test scores among the MCI patients had improved significantly after treatment There was no significant change in average Boston naming test scores before and after treatment.PS0 amplitudes had decreased significantly after treatment,but P300 amplitude was elevated and latency significantly shortened compared with before treatment.PS0 amplitude was positively correlated with P300 latency in these MCI patients before treatment,but both P300 latencies and PS0 amplitudes showed a negative correlation with scores on the memory sub-tests.Conclusions These results suggest that donepezil may improve cognitive function among MCI patients,especially memory function.The PS0 and P300 components of auditory event-related potentials are objective and sensitive indicators to evaluate the cognition function of MCI patients,and they also can be used as indicators in assessing the efficacy of donepezil treatment of mild cognitive impairment.
