CAJ | 학술논문

目的研究不同治疗参数的660 nm红光照射对大鼠坐骨神经损伤修复作用.方法选取成年SD雄性大鼠45只,按随机数字表法分为对照组与治疗1、2、3、4组,每组9只.采用钳压法建立大鼠坐骨神经损伤模型,治疗1、2、3、4组分别采用不同参数(不同的功率密度和照射时间)的660 nm红光照射损伤部位,每日1次,连续治疗21d.5组大鼠均于术前和术后第7、14、21天进行神经电生理测定,测定其坐骨神经复合肌动作电位(CMAP)潜伏期、波幅、坐骨神经传导速度,并于术前和术后第4、7、14、21天采用坐骨神经功能指数(SFI)进行行走功能评价.结果术后第21天,治疗1、2、3、4组大鼠的CMAP潜伏期和波幅与对照组比较,差异无统计学意义(P＞0.05)；治疗3组和对照组坐骨神经传导速度分别为(36.06±1.84) m/s和(30.60±5.04) m/s,差异有统计学意义(P＜0.05)；治疗2组、治疗3组和对照组SFI负值分别为(-10.88±11.16)、(-11.91 ±7.11)和(-21.26 ±4.79),组间差异均有统计学意义(P＜0.05).结论红光照射可促进大鼠坐骨神经损伤修复,改善其行走功能.
목적 연구불동치료삼수적660 nm홍광조사대대서좌골신경손상수복작용.방법 선취성년SD웅성대서45지,안수궤수자표법분위대조조여치료1、2、3、4조,매조9지.채용겸압법건립대서좌골신경손상모형,치료1、2、3、4조분별채용불동삼수(불동적공솔밀도화조사시간)적660 nm홍광조사손상부위,매일1차,련속치료21d.5조대서균우술전화술후제7、14、21천진행신경전생리측정,측정기좌골신경복합기동작전위(CMAP)잠복기、파폭、좌골신경전도속도,병우술전화술후제4、7、14、21천채용좌골신경공능지수(SFI)진행행주공능평개.결과 술후제21천,치료1、2、3、4조대서적CMAP잠복기화파폭여대조조비교,차이무통계학의의(P＞0.05)；치료3조화대조조좌골신경전도속도분별위(36.06±1.84) m/s화(30.60±5.04) m/s,차이유통계학의의(P＜0.05)；치료2조、치료3조화대조조SFI부치분별위(-10.88±11.16)、(-11.91 ±7.11)화(-21.26 ±4.79),조간차이균유통계학의의(P＜0.05).결론 홍광조사가촉진대서좌골신경손상수복,개선기행주공능.
Objective To explore the therapeutic effects of 660 nm red light on sciatic nerve injury in adult rats.Methods Forty-five adult,male rats were divided into a control group and treatment groups 1,2,3 and 4.Sciatic nerve injury was modeled by crushing the nerve.The treatment groups received irradiation with red light once daily for 21 consecutive days.The power density of red light and irradiation time varied among the groups.The latency and amplitude of compound muscle action potentials (CMAPs) and nerve conductive velocity were examined at different time points.The Sciatic Function Index (SFI) was used to evaluate walking function.Results After 21 days of red light therapy no statistically significant differences were observed between the control group and treatment groups 1 to 4 with regard to the latency or the amplitude of the CMAPs.There was a significant difference between the control group and treatment group 3 in terms of sciatic nerve conduction velocity.The average Sciatic Function Indexes of treatment groups 2,3 were significantly different from that of the control group.Conclusion Red light irradiation can promote recovery after sciatic nerve injury,at least in rats,thereby improving walking function.