中华物理医学与康复杂志
中華物理醫學與康複雜誌
중화물리의학여강복잡지
CHINESE JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
2014年
3期
171-174
,共4页
钟明华%李培媛%朱其秀%刘云霞
鐘明華%李培媛%硃其秀%劉雲霞
종명화%리배원%주기수%류운하
脑外伤%认知功能障碍%事件相关电位%P300%蒙特利尔认知评估量表
腦外傷%認知功能障礙%事件相關電位%P300%矇特利爾認知評估量錶
뇌외상%인지공능장애%사건상관전위%P300%몽특리이인지평고량표
Traumatic brain injury%Cognitive dysfunction%Event-related potentials%P300%Montreal cognitive assessment
目的 研究脑外伤患者事件相关电位(ERP) P300与认知功能的相关性,探讨其在检测脑外伤患者认知功能障碍方面的应用价值.方法 采用随机对照方法,分别对入选的30例脑外伤患者(病例组)和28例健康志愿者(对照组)进行P300检测和蒙特利尔认知评估量表(MoCA)评定,分析其相关性.结果 与对照组比较,病例组视空间与执行能力[(2.70±0.75)分]、注意[(2.23±0.68)分]、抽象[(0.87±0.63)分]、延迟记忆[(2.13±0.82)分]、定向力[(2.63±0.93)分]等子项目得分及MoCA总分[(16.03±3.00)分]较低,差异有统计学意义(P＜0.05);病例组N1、P2、N2、P3潜伏期较对照组延长(P＜0.05),P2、P3波幅较对照组低(P＜0.05).通过逐步回归多元分析,发现P300潜伏期与延迟记忆、视空间与执行功能呈负相关(r=-0.673,r=-0.702,P＜0.05),与MoCA总评分亦呈负相关(r=-0.827,P＜0.05).结论 P300是一种被量化的电生理指标,可用于脑外伤患者认知功能障碍的评估.
目的 研究腦外傷患者事件相關電位(ERP) P300與認知功能的相關性,探討其在檢測腦外傷患者認知功能障礙方麵的應用價值.方法 採用隨機對照方法,分彆對入選的30例腦外傷患者(病例組)和28例健康誌願者(對照組)進行P300檢測和矇特利爾認知評估量錶(MoCA)評定,分析其相關性.結果 與對照組比較,病例組視空間與執行能力[(2.70±0.75)分]、註意[(2.23±0.68)分]、抽象[(0.87±0.63)分]、延遲記憶[(2.13±0.82)分]、定嚮力[(2.63±0.93)分]等子項目得分及MoCA總分[(16.03±3.00)分]較低,差異有統計學意義(P＜0.05);病例組N1、P2、N2、P3潛伏期較對照組延長(P＜0.05),P2、P3波幅較對照組低(P＜0.05).通過逐步迴歸多元分析,髮現P300潛伏期與延遲記憶、視空間與執行功能呈負相關(r=-0.673,r=-0.702,P＜0.05),與MoCA總評分亦呈負相關(r=-0.827,P＜0.05).結論 P300是一種被量化的電生理指標,可用于腦外傷患者認知功能障礙的評估.
목적 연구뇌외상환자사건상관전위(ERP) P300여인지공능적상관성,탐토기재검측뇌외상환자인지공능장애방면적응용개치.방법 채용수궤대조방법,분별대입선적30례뇌외상환자(병례조)화28례건강지원자(대조조)진행P300검측화몽특리이인지평고량표(MoCA)평정,분석기상관성.결과 여대조조비교,병례조시공간여집행능력[(2.70±0.75)분]、주의[(2.23±0.68)분]、추상[(0.87±0.63)분]、연지기억[(2.13±0.82)분]、정향력[(2.63±0.93)분]등자항목득분급MoCA총분[(16.03±3.00)분]교저,차이유통계학의의(P＜0.05);병례조N1、P2、N2、P3잠복기교대조조연장(P＜0.05),P2、P3파폭교대조조저(P＜0.05).통과축보회귀다원분석,발현P300잠복기여연지기억、시공간여집행공능정부상관(r=-0.673,r=-0.702,P＜0.05),여MoCA총평분역정부상관(r=-0.827,P＜0.05).결론 P300시일충피양화적전생리지표,가용우뇌외상환자인지공능장애적평고.
Objective To investigate any correlation between cognition and auditory event-related potential (ERP) after traumatic brain injury (TBI),and to explore the diagnostic value of the P300 ERP for TBI patients.Methods Thirty TBI patients and 28 healthy subjects were recruited.Their P300 auditory event-related potentials were measured and the Montreal cognitive assessment (MoCA) was administered.Results The TBI patients' total MoCA scores and their scores on most of the sub-item components were significantly lower than those of the control subjects,though their naming and speech showed no significant difference.The TBI patients had abnormal P300 responses.Their N1,P2,N2 and P3 latencies were significantly longer and their P2 and P3 amplitudes were significantly lower than those of the control group.Stepwise regression and multivariate analysis showed that the P300 latency was significantly associated with delayed memory,impaired visual spatial executive functioning and total MoCA score.Conclusion P300 can be used as a quantitative electrophysiological index for detecting cognitive impairment in patients with TBI.
